{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:06:02Z","timestamp":1787065562318,"version":"build-2736575974"},"reference-count":52,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s248892","type":"journal-article","created":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T16:34:20Z","timestamp":1595176460000},"page":"2865-2876","source":"Crossref","is-referenced-by-count":52,"title":["&lt;p&gt;Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2\/STAT3\/NF-\u03baB Signaling Pathway Modulation&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Min","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xili","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danqing","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0140-6736(15)00551-6","volume":"387","author":"Zhou","year":"2016","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/ijs.12350","volume":"10","author":"Zevallos","year":"2015","journal-title":"Int J Stroke"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1161\/01.ATV.18.4.503","volume":"18","author":"Pantoni","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"117160","DOI":"10.1016\/j.lfs.2019.117160","volume":"241","author":"Zhao","year":"2020","journal-title":"Life Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jsbmb.2012.11.006","volume":"137","author":"Johann","year":"2013","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nri855","volume":"2","author":"Thery","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"116632","DOI":"10.1016\/j.lfs.2019.116632","volume":"232","author":"Wei","year":"2019","journal-title":"Life Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"37421","DOI":"10.1021\/acsami.9b10126","volume":"11","author":"Mardpour","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"E2758","DOI":"10.3390\/ijms20112758","volume":"20","author":"Carrasco","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/intimm\/dxx002","volume":"29","author":"Liew","year":"2017","journal-title":"Int Immunol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"108818","DOI":"10.1016\/j.biopha.2019.108818","volume":"115","author":"Zhou","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"754","DOI":"10.5966\/sctm.2015-0197","volume":"5","author":"Ophelders","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"8633","DOI":"10.4049\/jimmunol.181.12.8633","volume":"181","author":"Sag","year":"2008","journal-title":"J Immunol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrm3311","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.intimp.2016.09.024","volume":"40","author":"Qiu","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"4717258","DOI":"10.1155\/2020\/4717258","volume":"2020","author":"Yu","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e0149991","DOI":"10.1371\/journal.pone.0149991","volume":"11","author":"Song","year":"2016","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1186\/s12885-018-5130-y","volume":"18","author":"Li","year":"2018","journal-title":"BMC Cancer"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.phymed.2013.08.016","volume":"21","author":"Zeng","year":"2014","journal-title":"Phytomedicine"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.cytogfr.2017.10.001","volume":"38","author":"Jere","year":"2017","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.cyto.2011.07.018","volume":"56","author":"Zhao","year":"2011","journal-title":"Cytokine"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"96","DOI":"10.4103\/1673-5374.198992","volume":"12","author":"Hu","year":"2017","journal-title":"Neural Regen Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.neulet.2013.03.004","volume":"542","author":"Lu","year":"2013","journal-title":"Neurosci Lett"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"113045","DOI":"10.1016\/j.expneurol.2019.113045","volume":"322","author":"Dong","year":"2019","journal-title":"Exp Neurol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.7150\/ijms.9282","volume":"11","author":"Shao","year":"2014","journal-title":"Int J Med Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"989340","DOI":"10.1155\/2014\/105186","volume":"(2014)","author":"Zhang","year":"2014","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"117036","DOI":"10.1016\/j.lfs.2019.117036","volume":"239","author":"Liu","year":"2019","journal-title":"Life Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/978-1-60327-169-1_12","volume":"449","author":"Phinney","year":"2008","journal-title":"Methods Mol Biol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s12974-019-1602-5","volume":"16","author":"Dabrowska","year":"2019","journal-title":"J Neuroinflammation"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1002\/term.2947","volume":"13","author":"Wei","year":"2019","journal-title":"J Tissue Eng Regen Med"},{"key":"ref33","first-page":"1053","volume":"10","author":"Chang","year":"2018","journal-title":"Am J Transl Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1097\/SHK.0000000000000617","volume":"46","author":"Day","year":"2016","journal-title":"Shock"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s12906-019-2703-5","volume":"19","author":"Ma","year":"2019","journal-title":"BMC Complement Altern Med"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/jnc.13922","volume":"140","author":"Shen","year":"2017","journal-title":"J Neurochem"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"5007","DOI":"10.3892\/mmr.2018.8477","volume":"17","author":"Wu","year":"2018","journal-title":"Mol Med Rep"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1111\/j.1471-4159.2006.04051.x","volume":"98","author":"Satriotomo","year":"2006","journal-title":"J Neurochem"},{"key":"ref39","first-page":"208","volume":"27","author":"Xie","year":"2007","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1042\/BST0341267","volume":"34","author":"Planas","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1007\/s12035-017-0432-7","volume":"55","author":"Alhadidi","year":"2018","journal-title":"Mol Neurobiol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.1161\/STROKEAHA.117.018505","volume":"48","author":"Qin","year":"2017","journal-title":"Stroke"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s12974-019-1571-8","volume":"16","author":"Dabrowska","year":"2019","journal-title":"J Neuroinflammation"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"105","DOI":"10.4161\/org.7.2.15782","volume":"7","author":"Tetta","year":"2011","journal-title":"Organogenesis"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1681\/ASN.2008070798","volume":"20","author":"Bruno","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1002\/glia.23445","volume":"66","author":"Blandford","year":"2018","journal-title":"Glia"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"E3536","DOI":"10.1073\/pnas.1703920114","volume":"114","author":"Long","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1007\/s12035-016-9851-0","volume":"54","author":"Zhang","year":"2017","journal-title":"Mol Neurobiol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1210\/en.2016-1819","volume":"158","author":"El Bassit","year":"2017","journal-title":"Endocrinology"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/stem.1409","volume":"31","author":"Xin","year":"2013","journal-title":"Stem Cells"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.5966\/sctm.2015-0078","volume":"4","author":"Doeppner","year":"2015","journal-title":"Stem Cells Transl Med"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"44433","DOI":"10.1038\/srep44433","volume":"7","author":"Otero-Ortega","year":"2017","journal-title":"Sci Rep"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=59846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=59846","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T16:34:22Z","timestamp":1595176462000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/neuroprotective-effect-of-mesenchymal-stromal-cell-derived-extracellul-peer-reviewed-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":52,"URL":"https:\/\/doi.org\/10.2147\/dddt.s248892","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}