{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:22:43Z","timestamp":1791948163753,"version":"4.3.4"},"reference-count":41,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s261216","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T21:42:12Z","timestamp":1595886132000},"page":"3015-3027","source":"Crossref","is-referenced-by-count":61,"title":["<p>Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats<\/p>"],"prefix":"10.2147","volume":"Volume 14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8274-1993","authenticated-orcid":true,"given":"Taiyang","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haosheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yancheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peimin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1097\/BOR.0000000000000479","volume":"30","author":"Vina","year":"2018","journal-title":"Curr Opin Rheumatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s11657-017-0325-4","volume":"12","author":"Ishidou","year":"2017","journal-title":"Arch Osteoporos"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1002\/acr.23162","volume":"69","author":"Wallace","year":"2017","journal-title":"Arthritis Care Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1136\/annrheumdis-2014-205894","volume":"75","author":"Atukorala","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"ref6","first-page":"126","volume":"31","author":"Ostojic","year":"2019","journal-title":"Psychiatr Danub"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/j.joca.2018.07.001","volume":"26","author":"Ashraf","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.joca.2018.02.901","volume":"26","author":"McAllister","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"5463","DOI":"10.3892\/mmr.2018.8520","volume":"17","author":"Zhao","year":"2018","journal-title":"Mol Med Rep"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.canlet.2018.01.034","volume":"419","author":"Jiang","year":"2018","journal-title":"Cancer Lett"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/ijms20133328","volume":"20","author":"Kelley","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/s0031-9422(97)00514-1","volume":"46","author":"Williams","year":"1997","journal-title":"Phytochemistry"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/ijms19124073","volume":"19","author":"Mohos","year":"2018","journal-title":"Int J Mol Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e1501780","DOI":"10.1126\/sciadv.1501780","volume":"2","author":"Zhao","year":"2016","journal-title":"Sci Adv"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/cmi.2015.107","volume":"14","author":"Meng","year":"2017","journal-title":"Cell Mol Immunol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s10753-017-0558-9","volume":"40","author":"Zheng","year":"2017","journal-title":"Inflammation"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.taap.2014.05.018","volume":"279","author":"Darwish","year":"2014","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"108619","DOI":"10.1016\/j.biopha.2019.108619","volume":"112","author":"El","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.ejphar.2017.11.008","volume":"818","author":"George","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.cbi.2017.10.019","volume":"279","author":"Goes","year":"2018","journal-title":"Chem Biol Interact"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"6326517","DOI":"10.1155\/2019\/6326517","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"104496","DOI":"10.1016\/j.neuint.2019.104496","volume":"129","author":"Li","year":"2019","journal-title":"Neurochem Int"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13020-020-0290-5","volume":"15","author":"Wu","year":"2020","journal-title":"Chin Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/s0304-3959(98)00017-7","volume":"75","author":"Jasmin","year":"1998","journal-title":"Pain"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1007\/s10753-017-0724-0","volume":"41","author":"Yin","year":"2018","journal-title":"Inflammation"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.joca.2018.10.014","volume":"27","author":"Minten","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13075-017-1229-9","volume":"19","author":"Mathiessen","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.intimp.2016.01.005","volume":"32","author":"Yao","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.fct.2017.10.025","volume":"110","author":"Choi","year":"2017","journal-title":"Food Chem Toxicol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1124\/jpet.112.201863","volume":"345","author":"Dou","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.neulet.2010.08.064","volume":"485","author":"Ha","year":"2010","journal-title":"Neurosci Lett"},{"key":"ref33","first-page":"243","volume":"38","author":"Qi","year":"2018","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.3892\/etm.2019.7189","volume":"17","author":"Xu","year":"2019","journal-title":"Exp Ther Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cbi.2016.03.015","volume":"250","author":"Rani","year":"2016","journal-title":"Chem Biol Interact"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.lfs.2019.04.027","volume":"226","author":"Sarkaki","year":"2019","journal-title":"Life Sci"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666200123093544","volume":"27","author":"Su","year":"2020","journal-title":"Curr Med Chem"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"3559","DOI":"10.2147\/DDDT.S216596","volume":"13","author":"Wang","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"561459","DOI":"10.1155\/2014\/561459","volume":"2014","author":"Wojdasiewicz","year":"2014","journal-title":"Mediators Inflamm"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1002\/jor.22976","volume":"33","author":"Yamaguchi","year":"2015","journal-title":"J Orthop Res"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2165918","DOI":"10.1155\/2019\/2165918","volume":"2019","author":"Zhang","year":"2019","journal-title":"Mediators Inflamm"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=60101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=60101","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T21:42:15Z","timestamp":1595886135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/chrysin-attenuates-the-nlrp3-inflammasome-cascade-to-reduce-synovitis--peer-reviewed-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":41,"URL":"https:\/\/doi.org\/10.2147\/dddt.s261216","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]}}}