{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:39:39Z","timestamp":1787024379398,"version":"build-2736575974"},"reference-count":47,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s274018","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T14:32:12Z","timestamp":1606660332000},"page":"5259-5273","source":"Crossref","is-referenced-by-count":7,"title":["&lt;p&gt;Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS\/MS: An in silico and Practical Bioactivation Approach&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5910-2832","authenticated-orcid":true,"given":"Ali S","family":"Abdelhameed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1147-4960","authenticated-orcid":true,"given":"Mohamed W","family":"Attwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan A","family":"Kadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,11]]},"reference":[{"key":"ref1","unstructured":"World Health Organization. Department of information, evidence and research, WHO cancer fact sheet; 2018. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer. Accessed May 10, 2020."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1126\/science.278.5340.1036","volume":"278","author":"Barinaga","year":"1997","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int J Cancer"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"740","DOI":"10.6004\/jnccn.2010.0056","volume":"8","author":"Ettinger","year":"2010","journal-title":"J Natl Comprehen Cancer Netw"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1097\/PPO.0b013e31823e701a","volume":"17","author":"Larsen","year":"2011","journal-title":"Cancer J (Sudbury, Mass)"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1164\/rccm.201305-0843PP","volume":"188","author":"Cardarella","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1200\/JCO.2012.45.3753","volume":"31","author":"Li","year":"2013","journal-title":"J Clin Oncol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.cllc.2012.01.004","volume":"13","author":"Moreira","year":"2012","journal-title":"Clin Lung Cancer"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1126\/science.1650499","volume":"253","author":"Fisher","year":"1991","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.ctrv.2013.07.002","volume":"40","author":"Gridelli","year":"2014","journal-title":"Cancer Treat Rev"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1016\/S0140-6736(10)62101-0","volume":"378","author":"Goldstraw","year":"2011","journal-title":"Lancet"},{"key":"ref12","author":"Sen Zhang","year":"2010","journal-title":"AACR Poster Session"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Squillace RM, Anjum R, Miller D, et al. AP26113 possesses pan-inhibitory activity versus crizotinib-resistant ALK mutants and oncogenic ROS1 fusions. 2013.","DOI":"10.1158\/1538-7445.AM2013-5655"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1080\/13543784.2017.1324572","volume":"26","author":"Karachaliou","year":"2017","journal-title":"Expert Opin Investig Drugs"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.21037\/atm.2017.11.34","volume":"6","author":"Ziogas","year":"2018","journal-title":"Ann Transl Med"},{"key":"ref16","author":"Horn","year":"2018","journal-title":"Clin Cancer Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-17-2398","author":"Horn","year":"2018","journal-title":"Clin Cancer Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1021\/tx034170b","volume":"17","author":"Evans","year":"2004","journal-title":"Chem Res Toxicol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"379","DOI":"10.2174\/1389200023337360","volume":"3","author":"Kalgutkar","year":"2002","journal-title":"Curr Drug Metab"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"439","DOI":"10.2174\/1389200023337315","volume":"3","author":"Boelsterli","year":"2002","journal-title":"Curr Drug Metab"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1016\/S0140-6736(00)03137-8","volume":"356","author":"Knowles","year":"2000","journal-title":"Lancet"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"367","DOI":"10.2174\/1389200023337333","volume":"3","author":"Ju","year":"2002","journal-title":"Curr Drug Metab"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cbi.2008.09.014","volume":"179","author":"Ma","year":"2009","journal-title":"Chem Biol Interact"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1021\/tx200168d","volume":"24","author":"Stepan","year":"2011","journal-title":"Chem Res Toxicol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"4862","DOI":"10.1039\/C8RA09812C","volume":"9","author":"AlRabiah","year":"2019","journal-title":"RSC Adv"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"783","DOI":"10.2147\/DDDT.S239458","volume":"14","author":"Attwa","year":"2020","journal-title":"Drug Des Devel Ther"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2174\/138920011794520044","volume":"12","author":"Masic","year":"2011","journal-title":"Curr Drug Metab"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1021\/tx0496789","volume":"18","author":"Zhang","year":"2005","journal-title":"Chem Res Toxicol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/nrd3408","volume":"10","author":"Park","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s13065-018-0467-5","volume":"12","author":"Attwa","year":"2018","journal-title":"Chem Cent J"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1021\/tx100296v","volume":"23","author":"Waldon","year":"2010","journal-title":"Chem Res Toxicol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1002\/jms.1098","volume":"41","author":"Ma","year":"2006","journal-title":"J Mass Spectrom"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.drudis.2008.11.002","volume":"14","author":"Tolonen","year":"2009","journal-title":"Drug Discov Today"},{"key":"ref34","first-page":"32","volume":"13","author":"Zweig","year":"2017","journal-title":"Am J Hematol Oncol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1021\/acscentsci.6b00162","volume":"2","author":"Hughes","year":"2016","journal-title":"ACS Cent Sci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1093\/bioinformatics\/btu761","volume":"31","author":"Matlock","year":"2015","journal-title":"Bioinformatics"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.1021\/ci400518g","volume":"53","author":"Zaretzki","year":"2013","journal-title":"J Chem Inf Model"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e0214598","DOI":"10.1371\/journal.pone.0214598","volume":"14","author":"Abdelhameed","year":"2019","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e3793","DOI":"10.1002\/bmc.3793","volume":"31","author":"Abdelhameed","year":"2017","journal-title":"Biomed Chromatogr"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1002\/bmc.3674","volume":"30","author":"Kadi","year":"2016","journal-title":"Biomed Chromatogr"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"190434","DOI":"10.1098\/rsos.190434","volume":"6","author":"Abdelhameed","year":"2019","journal-title":"Royal Soc Open Sci"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"5412","DOI":"10.1039\/C9RA09115G","volume":"10","author":"Attwa","year":"2020","journal-title":"RSC Adv"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"10700","DOI":"10.1021\/acs.jmedchem.8b01326","volume":"61","author":"Mandal","year":"2018","journal-title":"J Med Chem"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"6409","DOI":"10.1039\/C8RA10322D","volume":"9","author":"AlRabiah","year":"2019","journal-title":"RSC Adv"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1002\/jssc.201900818","volume":"43","author":"Attwa","year":"2020","journal-title":"J Sep Sci"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"38733","DOI":"10.1039\/C8RA06709K","volume":"8","author":"Attwa","year":"2018","journal-title":"RSC Adv"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jpba.2018.11.033","volume":"164","author":"Attwa","year":"2019","journal-title":"J Pharm Biomed Anal"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=64243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=64243","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T14:32:26Z","timestamp":1606660346000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/characterization-of-stable-and-reactive-metabolites-of-the-anticancer--peer-reviewed-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":47,"URL":"https:\/\/doi.org\/10.2147\/dddt.s274018","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}