{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:14:55Z","timestamp":1790738095744,"version":"4.1.0"},"reference-count":76,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s278588","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T21:05:59Z","timestamp":1605042359000},"page":"4855-4867","source":"Crossref","is-referenced-by-count":31,"title":["<p>Indole: The After Next Scaffold of Antiplasmodial Agents?<\/p>"],"prefix":"10.2147","volume":"Volume 14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-068X","authenticated-orcid":true,"given":"Abdrrahman Shemsu","family":"Surur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon Assefa","family":"Huluka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melese Legesse","family":"Mitku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaleab","family":"Asres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,11]]},"reference":[{"key":"ref1","unstructured":"World malaria report 2019. 2019. Available from: https:\/\/www.who.int\/news-room\/feature-stories\/detail\/world-malaria-report-2019. Accessed October 13, 2020."},{"key":"ref2","unstructured":"World malaria report 2018. 2019. Available from: https:\/\/www.mmv.org\/newsroom\/publications\/world-malaria-report-2018. Accessed October 13, 2020."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3109\/14756366.2015.1016513","volume":"31","author":"Kumar","year":"2016","journal-title":"J Enzyme Inhib Med Chem"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.biopha.2018.05.009","volume":"104","author":"Kumar","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/pathogens8010011","volume":"8","author":"Espinoza","year":"2019","journal-title":"Pathogens"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e338","DOI":"10.1016\/S1473-3099(19)30261-0","volume":"19","author":"Conrad","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00446","author":"Surur","year":"2020","journal-title":"ACS Med Chem Lett"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-144","volume":"10","author":"Achan","year":"2011","journal-title":"Malar J"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrd1416","volume":"3","author":"Fidock","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.coph.2018.06.003","volume":"42","author":"Suresh","year":"2018","journal-title":"Curr Opin Pharmacol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-2724-z","volume":"18","author":"Tse","year":"2019","journal-title":"Malar J"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201800248","author":"Surur","year":"2019","journal-title":"Arch Pharm Chem Life Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.ejmech.2018.08.040","volume":"158","author":"Kalaria","year":"2018","journal-title":"Eur J Med Chem"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"103021","DOI":"10.1016\/j.bioorg.2019.103021","volume":"89","author":"Kumari","year":"2019","journal-title":"Bioorg Chem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1016\/j.bmcl.2013.03.067","volume":"23","author":"Biamonte","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.trstmh.2007.10.002","volume":"102","author":"Frederich","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.ejmech.2015.07.047","volume":"102","author":"Santos","year":"2015","journal-title":"Eur J Med Chem"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-3026-1","volume":"18","author":"Tajuddeen","year":"2019","journal-title":"Malar J"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1021\/ol802506n","volume":"11","author":"Fernandez","year":"2009","journal-title":"Org Lett"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.ijantimicag.2010.05.008","volume":"36","author":"Fernandez","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"6936","DOI":"10.1021\/ja301387k","volume":"134","author":"Vallakati","year":"2012","journal-title":"J Am Chem Soc"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"5155","DOI":"10.1021\/jm100410f","volume":"53","author":"Yeung","year":"2010","journal-title":"J Med Chem"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1126\/science.1193225","volume":"329","author":"Rottmann","year":"2010","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1056\/NEJMoa1315860","volume":"371","author":"White","year":"2014","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ddr.20345","volume":"71","author":"Muregi","year":"2010","journal-title":"Drug Dev Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1111\/cbdd.12273","volume":"83","author":"Raj","year":"2014","journal-title":"Chem Biol Drug Des"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.bmcl.2013.12.109","volume":"24","author":"Raj","year":"2014","journal-title":"Bioorg Med Chem Lett"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.ejmech.2013.01.032","volume":"62","author":"Raj","year":"2013","journal-title":"Eur J Med Chem"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"6200","DOI":"10.1021\/jm400656s","volume":"56","author":"Teguh","year":"2013","journal-title":"J Med Chem"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2174\/1389557517666170807123201","volume":"18","author":"Singh","year":"2018","journal-title":"Mini Rev Med Chem"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.phymed.2012.09.008","volume":"20","author":"Rocha e Silva","year":"2012","journal-title":"Phytomedicine"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1016\/j.bmcl.2008.01.015","volume":"18","author":"Lavrado","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nsb729","volume":"18","author":"Lisgarten","year":"2019","journal-title":"Nat Struct Biol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s10870-008-9398-7","volume":"38","author":"Potter","year":"2008","journal-title":"J Chem Crystallogr"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ijpddr.2015.03.002","volume":"5","author":"Onambele","year":"2015","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"3998","DOI":"10.1016\/j.ijantimicag.2010.05.008","volume":"36","author":"Urgaonkar","year":"2010","journal-title":"Org Lett"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1128\/AAC.01714-10","volume":"55","author":"Barker","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"525","DOI":"10.4155\/fmc-2018-0246","volume":"11","author":"Vasconcelos","year":"2019","journal-title":"Future Med Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1021\/acs.jnatprod.7b00587","volume":"80","author":"Robertson","year":"2017","journal-title":"J Nat Prod"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-017-0181-2","volume":"7","author":"Ramsay","year":"2018","journal-title":"Clin Transl Med"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"6523","DOI":"10.1021\/jm058225d","volume":"48","author":"Morphy","year":"2005","journal-title":"J Med Chem"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.phymed.2011.03.010","volume":"18","author":"Passemar","year":"2011","journal-title":"Phytomedicine"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1016\/j.bmc.2005.02.017","volume":"13","author":"Kgokong","year":"2005","journal-title":"Bioorg Med Chem"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51604-z","volume":"9","author":"Herraiz","year":"2019","journal-title":"Sci Rep"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.1016\/j.bmc.2009.02.050","volume":"17","author":"Kaur","year":"2009","journal-title":"Bioorg Med Chem"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.chom.2012.12.006","volume":"13","author":"Spillman","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1021\/cb500616x","volume":"10","author":"Flannery","year":"2015","journal-title":"ACS Chem Biol"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1101\/2019.12.12.874826","author":"Ramanathan","year":"2019","journal-title":"bioRxiv"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.ijpddr.2015.07.001","volume":"5","author":"Spillman","year":"2015","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"E5455","DOI":"10.1073\/pnas.1414221111","volume":"111","author":"Jimenez-Diaz","year":"2014","journal-title":"PNAS"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jsb.2012.02.008","volume":"178","author":"Sacchetto","year":"2012","journal-title":"J Struct Biol"},{"key":"ref52","unstructured":"PfATP4. 2020. Available from: https:\/\/www.uniprot.org\/uniprot\/?query=PfATP4&sort=score. Accessed October 13, 2020."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41598-019-54339-z","author":"Dangi","year":"2019","journal-title":"Sci Rep"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.3390\/biom10091243","volume":"10","author":"Singh","year":"2020","journal-title":"Biomolecules"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.freeradbiomed.2008.10.032","volume":"46","author":"Dey","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/35017112","volume":"2","author":"Hotta","year":"2000","journal-title":"Nat Cell Biol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.bbrc.2014.02.070","volume":"446","author":"Furuyama","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ejmech.2019.02.019","volume":"168","author":"Luthra","year":"2019","journal-title":"Eur J Med Chem"},{"key":"ref59","first-page":"5","volume":"1","author":"Srinivasan","year":"2014","journal-title":"Austin J Infect Dis"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2174\/1874421400802010055","volume":"2","author":"Bagnaresi","year":"2008","journal-title":"Open Parasitol J"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.2174\/1874421400802010055","volume":"16","author":"Forkuo","year":"2017","journal-title":"Malar J"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.2174\/1874421400802010055","volume":"15","author":"Forkuo","year":"2016","journal-title":"Malar J"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s13659-020-00242-4","volume":"10","author":"Zhao","year":"2020","journal-title":"Nat Prod Bioprospect"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.toxlet.2011.09.010","volume":"207","author":"Gopalan","year":"2011","journal-title":"Toxicol Lett"},{"key":"ref65","volume-title":"Trease and Evan\u2019s Pharmacognosy","year":"2009"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/7076986","volume":"2019","author":"Mensah","year":"2019","journal-title":"Biochem Res Int"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s13659-020-00246-0","volume":"10","author":"Zhao","year":"2020","journal-title":"Nat Prod Bioprospect"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1093\/toxsci\/70.2.245","volume":"70","author":"Ansah","year":"2002","journal-title":"Toxicol Sci"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.3390\/molecules21121758","volume":"21","author":"Pal","year":"2016","journal-title":"Molecules"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.jep.2016.09.051","volume":"193","author":"Muganza","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.phytochem.2011.09.012","volume":"73","author":"Girardot","year":"2012","journal-title":"Phytochemistry"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.15419\/bmrat.v4i4.160","volume":"4","author":"Dokunmu","year":"2017","journal-title":"Biomed Res Ther"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3390\/ijms16010284","volume":"16","author":"Stiborova","year":"2014","journal-title":"Int J Mol Sci"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1021\/acs.jpcb.5b10121","volume":"120","author":"Kundu","year":"2016","journal-title":"J Phys Chem B"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"2876","DOI":"10.3390\/ijms21082876","volume":"21","author":"Li","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.exppara.2004.08.006","volume":"108","author":"Van Miert","year":"2004","journal-title":"Exp Parasitol"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=63602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=63602","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:18:16Z","timestamp":1697069896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/indole-the-after-next-scaffold-of-antiplasmodial-agents-peer-reviewed-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":76,"URL":"https:\/\/doi.org\/10.2147\/dddt.s278588","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}