{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:32:57Z","timestamp":1791952377517,"version":"4.3.4"},"reference-count":83,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s281639","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T22:40:17Z","timestamp":1624833617000},"page":"2815-2830","source":"Crossref","is-referenced-by-count":55,"title":["Profiling Pretomanid as a Therapeutic Option for TB Infection: Evidence to Date"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Stephani L","family":"Stancil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuad","family":"Mirzayev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Abdel-Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"ref1","unstructured":"Global tuberculosis report. Geneva, Switzerland: World Health Organization; 2020. Available from: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/336069\/9789240013131-eng.pdf. Accessed March 15, 2021."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/35016103","volume":"405","author":"Stover","year":"2000","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1021\/acsmedchemlett.7b00356","volume":"8","author":"Thompson","year":"2017","journal-title":"ACS Med Chem Lett"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/med.21602","volume":"40","author":"Bahuguna","year":"2020","journal-title":"Med Res Rev"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.ejmech.2019.06.068","volume":"179","author":"Zhang","year":"2019","journal-title":"Eur J Med Chem"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"15726","DOI":"10.1021\/acs.jmedchem.0c01372","volume":"63","author":"Ang","year":"2020","journal-title":"J Med Chem"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1289\/ehp.8564199","volume":"64","author":"Moreno","year":"1985","journal-title":"Environ Health Perspect"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1126\/science.1164571","volume":"322","author":"Singh","year":"2008","journal-title":"Science"},{"key":"ref9","unstructured":"Center for Drug Evaluaton and Research. Approval package for application number 212862Orig1s000. 2019."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"12828","DOI":"10.1073\/pnas.93.23.12828","volume":"93","author":"Yuan","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e81985","DOI":"10.1371\/journal.pone.0081985","volume":"8","author":"Purwantini","year":"2013","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"5084","DOI":"10.1038\/s41598-018-23110-1","volume":"8","author":"Baptista","year":"2018","journal-title":"Sci Rep"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1128\/JB.184.9.2420-2428.2002","volume":"184","author":"Choi","year":"2002","journal-title":"J Bacteriol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"5316","DOI":"10.1128\/AAC.00308-15","volume":"59","author":"Haver","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1073\/pnas.0508392103","volume":"103","author":"Manjunatha","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1007\/s10096-019-03551-w","volume":"38","author":"Wen","year":"2019","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1093\/jac\/dkaa136","volume":"75","author":"Kadura","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1038\/s41467-019-09534-x","volume":"10","author":"Bashiri","year":"2019","journal-title":"Nat Commun"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/AAC.01948-20","volume":"65","author":"Rifat","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1046\/j.1365-2958.2003.03425.x","volume":"48","author":"Sassetti","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"12989","DOI":"10.1073\/pnas.2134250100","volume":"100","author":"Sassetti","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e1002946","DOI":"10.1371\/journal.ppat.1002946","volume":"8","author":"Zhang","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"8327","DOI":"10.1073\/pnas.0503272102","volume":"102","author":"Rengarajan","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1086\/652497","volume":"201","author":"Dutta","year":"2010","journal-title":"J Infect Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e1008287","DOI":"10.1371\/journal.ppat.1008287","volume":"16","author":"Lee","year":"2020","journal-title":"PLoS Pathog"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/mmi.12127","volume":"87","author":"Gurumurthy","year":"2013","journal-title":"Mol Microbiol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1128\/AAC.00179-15","volume":"59","author":"Klitgaard","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1128\/AAC.00152-16","volume":"60","author":"Makafe","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.tube.2017.12.006","volume":"108","author":"Fujiwara","year":"2018","journal-title":"Tuberculosis (Edinb)"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/jac\/dkt364","volume":"69","author":"McGrath","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1093\/infdis\/jir786","volume":"205","author":"Harper","year":"2012","journal-title":"J Infect Dis"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1128\/AAC.00913-17","volume":"61","author":"Li","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1128\/AAC.49.6.2289-2293.2005","volume":"49","author":"Tyagi","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1093\/jac\/dkn307","volume":"62","author":"Hurdle","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1128\/AAC.02693-13","volume":"58","author":"Hartkoorn","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.tube.2012.07.003","volume":"92","author":"Franzblau","year":"2012","journal-title":"Tuberculosis (Edinb)"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1128\/AAC.03823-14","volume":"59","author":"Upton","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"815","DOI":"10.2147\/IDR.S240716","volume":"13","author":"Zhang","year":"2020","journal-title":"Infect Drug Resist"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/molecules25102431","volume":"25","author":"Zhuang","year":"2020","journal-title":"Molecules"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e466","DOI":"10.1371\/journal.pmed.0030466","volume":"3","author":"Matsumoto","year":"2006","journal-title":"PLoS Med"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1093\/jac\/dky152","volume":"73","author":"Stott","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s40262-018-0716-8","volume":"58","author":"Daskapan","year":"2019","journal-title":"Clin Pharmacokinet"},{"key":"ref43","unstructured":"Abdel-Rahman SM. CPMT project no. 16-020: review of evidence on the use of delamanid supplementing MDR-TB treatment regimens in children aged 6 years and above. Technical Study report prepared for the World Health Organization. Final Report. Geneva, Switzerland. July 1, 2016."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1128\/AAC.49.6.2294-2301.2005","volume":"49","author":"Lenaerts","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.ijantimicag.2014.07.012","volume":"44","author":"Dutta","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1128\/AAC.02658-13","volume":"58","author":"Lanoix","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1128\/AAC.03822-14","volume":"59","author":"Tasneen","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"3910","DOI":"10.1128\/AAC.00761-13","volume":"57","author":"Dutta","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1128\/AAC.00849-10","volume":"55","author":"Ahmad","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1128\/AAC.01610-20","volume":"64","author":"Drusano","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"ref51","first-page":"2","volume":"65","author":"Drusano","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/bcp.14371","volume":"87","author":"Muliaditan","year":"2021","journal-title":"Br J Clin Pharmacol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1016\/S0140-6736(14)62002-X","volume":"385","author":"Dawson","year":"2015","journal-title":"Lancet"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1128\/AAC.06125-11","volume":"56","author":"Diacon","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1164\/rccm.201410-1801OC","volume":"191","author":"Diacon","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/S0140-6736(12)61080-0","volume":"380","author":"Diacon","year":"2012","journal-title":"Lancet"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/AAC.01121-20","volume":"65","author":"Nedelman","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"ref58","first-page":"211","volume":"10","author":"Lyons","year":"2021","journal-title":"CPT"},{"key":"ref59","unstructured":"Center for Drug Evaluaton and Research. Product quality review for application number 212862Orig1s000. October 15, 2017."},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02359-17","volume":"62","author":"Lyons","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1128\/AAC.00106-09","volume":"53","author":"Ginsberg","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"5516","DOI":"10.1128\/AAC.00798-13","volume":"57","author":"Winter","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1128\/AAC.01196-20","volume":"65","author":"Ignatius","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"ref64","unstructured":"Pretomanid [labeling]. New York: Mylan; 2019."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3109\/00498254.2015.1067935","volume":"46","author":"Shobo","year":"2016","journal-title":"Xenobiotica"},{"key":"ref66","unstructured":"Center for Drug Evaluaton and Research. Multidisciplinary review for application number 212862Orig1s000. August 13, 2019."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"5245","DOI":"10.1128\/AAC.03332-14","volume":"58","author":"Dooley","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1128\/AAC.02632-12","volume":"57","author":"Winter","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jpba.2014.03.046","volume":"97","author":"Wang","year":"2014","journal-title":"J Pharm Biomed Anal"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/chromsci\/bmy002","volume":"56","author":"Wang","year":"2018","journal-title":"J Chromatogr Sci"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"3726","DOI":"10.1128\/AAC.00112-09","volume":"53","author":"Ginsberg","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00445-19","volume":"63","author":"Li","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"ref73","unstructured":"Pretomanid. Drugs and Lactation Database (Lactmed). Bethesda (MD): National Library of Medicine (US); 2020."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1097\/AOG.0000000000003890","volume":"135","author":"Miele","year":"2020","journal-title":"Obstet Gynecol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1056\/NEJMoa1901814","volume":"382","author":"Conradie","year":"2020","journal-title":"N Engl J Med"},{"key":"ref76","unstructured":"Howell P. Final results of the NIX-TB clinical study of BPaL regimen for highly resistant tuberculosis. Presented at: Conference on Retroviruses and Opprotunistic Infections; March 6\u201310, 2021; Virtual Platform."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3201\/eid2701.203766","volume":"27","author":"Haley","year":"2021","journal-title":"Emerg Infect Dis"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"305","DOI":"10.5588\/ijtld.20.0513","volume":"25","author":"Tweed","year":"2021","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/S2213-2600(19)30366-2","volume":"7","author":"Tweed","year":"2019","journal-title":"Lancet Respir Med"},{"key":"ref80","unstructured":"TB Alliance. Pretomanid sponsor briefing document for the antimicrobial drugs advisory committee. Available from: https:\/\/www.fda.gov\/media\/127593\/download. Accessed March 5, 2021."},{"key":"ref81","unstructured":"World Health Organization. Guidelines approved by the guidelines review committee. In: WHO Consolidated Guidelines on Tuberculosis: Module 4: Treatment - Drug-Resistant Tuberculosis Treatment. Geneva: World Health Organization \u00a9 World Health Organization 2020; 2020."},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03300-2020","author":"Mirzayev","year":"2020","journal-title":"Eur Respir J"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"e036599","DOI":"10.1136\/bmjopen-2019-036599","volume":"10","author":"Sweeney","year":"2020","journal-title":"BMJ Open"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=71063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=71063","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T22:40:26Z","timestamp":1624833626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/profiling-pretomanid-as-a-therapeutic-option-for-tb-infection-evidence-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":83,"URL":"https:\/\/doi.org\/10.2147\/dddt.s281639","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}