{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:43:40Z","timestamp":1789062220788,"version":"build-2803163510"},"reference-count":72,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s282112","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T20:12:15Z","timestamp":1606335135000},"page":"5235-5250","source":"Crossref","is-referenced-by-count":48,"title":["&lt;p&gt;Prediction of Targets of Curculigoside A in Osteoporosis and Rheumatoid Arthritis Using Network Pharmacology and Experimental Verification&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8527-6329","authenticated-orcid":true,"given":"Jiawen","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8420-6759","authenticated-orcid":true,"given":"Zhanchuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8595-4713","authenticated-orcid":true,"given":"Cong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanfa","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1590\/S0004-27302010000200007","volume":"54","author":"Lacativa","year":"2010","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.3390\/ijms20071646","volume":"20","author":"Tang","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1016\/S0140-6736(07)60784-3","volume":"370","author":"Smolen","year":"2007","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.cell.2015.11.031","volume":"163","author":"Shen","year":"2015","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s00044-010-9311-8","volume":"20","author":"Peng","year":"2011","journal-title":"Med Chem Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"6721","DOI":"10.3390\/molecules16086721","volume":"16","author":"Li","year":"2011","journal-title":"Molecules"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.intimp.2015.10.027","volume":"29","author":"Jiang","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/s1875-5364(13)60037-0","volume":"11","author":"Li","year":"2013","journal-title":"Chin J Nat Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.carbpol.2018.09.059","volume":"203","author":"Wang","year":"2019","journal-title":"Carbohydr Polym"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.intimp.2015.11.026","volume":"30","author":"Ding","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.fitote.2017.01.009","volume":"117","author":"Wang","year":"2017","journal-title":"Fitoterapia"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.3892\/mmr.2019.9854","volume":"19","author":"Tan","year":"2019","journal-title":"Mol Med Report"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/nbt1007-1110","volume":"25","author":"Hopkins","year":"2007","journal-title":"Nat Biotechnol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1517\/17460441.2012.692673","volume":"7","author":"Wang","year":"2012","journal-title":"Expert Opin Drug Discov"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"4697","DOI":"10.3892\/etm.2017.5170","volume":"14","author":"Zeng","year":"2017","journal-title":"Exp Ther Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jpba.2019.02.041","volume":"169","author":"Tian","year":"2019","journal-title":"J Pharm Biomed Anal"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jep.2019.01.027","volume":"235","author":"Shi","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"5113","DOI":"10.12659\/MSM.904264","volume":"23","author":"Wang","year":"2017","journal-title":"Med Sci Monit"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1038\/s41598-017-01613-7","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1758-2946-6-13","volume":"6","author":"Ru","year":"2014","journal-title":"J Cheminform"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci Rep"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s10822-016-9915-2","volume":"30","author":"Yao","year":"2016","journal-title":"J Comput Aided Mol Des"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"W357","DOI":"10.1093\/nar\/gkz382","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"W214","DOI":"10.1093\/nar\/gkq537","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0169-409X(00)00129-0","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv Drug Deliv Rev"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/cmi.2015.63","volume":"13","author":"Wang","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1017\/S0007114510001704","volume":"104","author":"Kim","year":"2010","journal-title":"Br J Nutr"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e923996","DOI":"10.12659\/MSM.923996","volume":"26","author":"Yu","year":"2020","journal-title":"Med Sci Monit"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s13075-019-1935-6","volume":"21","author":"Ma","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.clim.2015.11.009","volume":"162","author":"Feng","year":"2016","journal-title":"Clin Immunol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s10753-015-0273-3","volume":"39","author":"Qin","year":"2016","journal-title":"Inflammation"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/jcb.25631","volume":"118","author":"Simann","year":"2017","journal-title":"J Cell Biochem"},{"key":"ref34","first-page":"841","volume":"36","author":"Jiao","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"21146","DOI":"10.1038\/srep21146","volume":"6","author":"Liu","year":"2016","journal-title":"Sci Rep"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"D976","DOI":"10.1093\/nar\/gky987","volume":"47","author":"Xu","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1038\/s41598-017-03039-7","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/s41467-019-09186-x","volume":"10","author":"Cheng","year":"2019","journal-title":"Nat Commun"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1039\/c5np00005j","volume":"32","author":"Kibble","year":"2015","journal-title":"Nat Prod Rep"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.2174\/1568026616666160530181328","volume":"16","author":"Ye","year":"2016","journal-title":"Curr Top Med Chem"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"109381","DOI":"10.1016\/j.biopha.2019.109381","volume":"120","author":"Jing","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"112044","DOI":"10.1016\/j.jep.2019.112044","volume":"242","author":"Ren","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.phrs.2016.06.018","volume":"111","author":"Poornima","year":"2016","journal-title":"Pharmacol Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/S1875-5364(17)30065-1","volume":"15","author":"Hu","year":"2017","journal-title":"Chin J Nat Med"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"6431","DOI":"10.1002\/jcb.27933","volume":"120","author":"Xue","year":"2019","journal-title":"J Cell Biochem"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S1875-5364(19)30031-7","volume":"17","author":"Hua","year":"2019","journal-title":"Chin J Nat Med"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.3389\/fphar.2019.01185","volume":"10","author":"Guo","year":"2019","journal-title":"Front Pharmacol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jep.2012.09.051","volume":"145","author":"Tao","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.3389\/fphar.2018.01472","volume":"9","author":"Zuo","year":"2018","journal-title":"Front Pharmacol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.4049\/jimmunol.153.5.2180","volume":"153","author":"McNiff","year":"1994","journal-title":"J Immunol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13075-019-1936-5","volume":"21","author":"Gosselt","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1038\/sj.ejcn.1600989","volume":"54","author":"Alonso-Aperte","year":"2000","journal-title":"Eur J Clin Nutr"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1002\/jcp.25303","volume":"231","author":"Noronha-Matos","year":"2016","journal-title":"J Cell Physiol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1172\/JCI38576","volume":"122","author":"Su","year":"2012","journal-title":"J Clin Invest"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2018.05.086","author":"Smallwood","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.freeradbiomed.2016.06.020","volume":"97","author":"Khojah","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.bone.2017.06.020","volume":"103","author":"Sapir-Koren","year":"2017","journal-title":"Bone."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1016\/j.yexcr.2013.07.022","volume":"319","author":"Chrzanowska-Wodnicka","year":"2013","journal-title":"Exp Cell Res"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/nyas.13861","volume":"1433","author":"Jeevaratnam","year":"2018","journal-title":"Ann N Y Acad Sci"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.coph.2013.04.001","volume":"13","author":"Leech","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1002\/1529-0131(200107)44:7<1555::AID-ART279>3.0.CO;2-M","volume":"44","author":"Zhang","year":"2001","journal-title":"Arthritis Rheum"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"105685","DOI":"10.1016\/j.intimp.2019.105685","volume":"74","author":"Song","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"25900","DOI":"10.1074\/jbc.M707692200","volume":"283","author":"Cahill","year":"2008","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.bcp.2017.04.010","volume":"136","author":"Hu","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.3389\/fimmu.2018.02228","volume":"9","author":"Liu","year":"2018","journal-title":"Front Immunol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1080\/10717544.2018.1472677","volume":"25","author":"Zhang","year":"2018","journal-title":"Drug Deliv"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.bcp.2019.03.029","volume":"165","author":"Siouti","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nrrheum.2016.91","volume":"12","author":"Udalova","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ijpharm.2018.05.058","volume":"547","author":"Liu","year":"2018","journal-title":"Int J Pharm"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/annrheumdis-2016-210630","volume":"76","author":"Boutet","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s00011-018-1176-1","volume":"67","author":"Pan","year":"2018","journal-title":"Inflamm Res"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ebiom.2017.03.039","volume":"18","author":"Han","year":"2017","journal-title":"EBioMedicine."}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=64168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=64168","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T23:01:27Z","timestamp":1697238087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/prediction-of-targets-of-curculigoside-a-in-osteoporosis-and-rheumatoi-peer-reviewed-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":72,"URL":"https:\/\/doi.org\/10.2147\/dddt.s282112","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}