{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:44:22Z","timestamp":1768873462684,"version":"3.49.0"},"reference-count":50,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s292826","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T19:51:30Z","timestamp":1616442690000},"page":"1299-1313","source":"Crossref","is-referenced-by-count":28,"title":["Synthesis of Michael Adducts as Key Building Blocks for Potential Analgesic Drugs: In vitro, in vivo and in silico Explorations"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Sajjad","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mater H","family":"Mahnashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bandar A","family":"Alyami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8816-1842","authenticated-orcid":true,"given":"Yahya S","family":"Alqahtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhat","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-2445","authenticated-orcid":true,"given":"Muhammad","family":"Ayaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-8370","authenticated-orcid":true,"given":"Muhammad","family":"Tariq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Sadiq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umer","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,3]]},"reference":[{"key":"ref1","unstructured":"Craig AD, Sorkin LS Pain and analgesia. e LS. 2001 May 30."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"111863","DOI":"10.1016\/j.ejmech.2019.111863","volume":"186","author":"Jan","year":"2020","journal-title":"Eur J Med Chem"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0005-7967(96)00058-7","volume":"34","author":"Crombez","year":"1996","journal-title":"Behav Res Ther"},{"key":"ref4","first-page":"272","volume":"1","author":"Fields","year":"1987","journal-title":"Pain"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s40265-015-0392-z","volume":"75","author":"Altman","year":"2015","journal-title":"Drugs"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/0973-7847.95849","volume":"6","author":"Petrovska","year":"2012","journal-title":"Pharmacogn Rev"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jare.2017.11.004","volume":"11","author":"Tallima","year":"2018","journal-title":"J Adv Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-22972-9","volume":"8","author":"Yadav","year":"2018","journal-title":"Sci Rep"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1111\/j.1747-0285.2011.01173.x","volume":"78","author":"Meena","year":"2011","journal-title":"Chem Biol Drug Des"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1007\/s12272-017-0945-7","volume":"41","author":"Yadav","year":"2018","journal-title":"Arch Pharm Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1136\/ard.62.6.501","volume":"62","author":"Martel-Pelletier","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"11934","DOI":"10.1002\/slct.202003664","volume":"5","author":"Sadiq","year":"2020","journal-title":"ChemistrySelect"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1002\/adsc.201100250","volume":"353","author":"Nugent","year":"2011","journal-title":"Adv Synth Catal"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"9287","DOI":"10.1039\/c2ob26382c","volume":"10","author":"Nugent","year":"2012","journal-title":"Org Biomol Chem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/nrd915","volume":"1","author":"Agranat","year":"2002","journal-title":"Nat Rev Drug Discov"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/BF00541922","volume":"26","author":"Ariens","year":"1984","journal-title":"Eur J Clin Pharmacol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.2147\/DDDT.S130601","volume":"11","author":"Yadav","year":"2017","journal-title":"Drug Des Devel Ther"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"753","DOI":"10.2174\/1389450115666140630102711","volume":"15","author":"Kumar Yadav","year":"2014","journal-title":"Curr Drug Targets"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1007\/s00894-011-1265-3","volume":"18","author":"Yadav","year":"2012","journal-title":"J Mol Model"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/cem.2488","volume":"27","author":"Yadav","year":"2013","journal-title":"J Chemom"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"4088","DOI":"10.1002\/chem.201103005","volume":"18","author":"Nugent","year":"2012","journal-title":"Chem Eur J"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.2147\/DDDT.S237420","volume":"14","author":"Ahmad","year":"2020","journal-title":"Drug Des Devel Ther"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1134\/S1070428019110174","volume":"55","author":"Bibi","year":"2019","journal-title":"Russian J Organic Chem"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.2147\/DDDT.S226080","volume":"13","author":"Ahmad","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"103128","DOI":"10.1016\/j.bioorg.2019.103128","volume":"91","author":"Hussain","year":"2019","journal-title":"Bioorg Chem"},{"key":"ref26","first-page":"2287","volume":"38","author":"Jan","year":"2019","journal-title":"Latin Am J Pharm"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13065-015-0107-2","volume":"9","author":"Sadiq","year":"2015","journal-title":"Chem Cent J"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"104168","DOI":"10.1016\/j.bioorg.2020.104168","volume":"104","author":"Munir","year":"2020","journal-title":"Bioorg Chem"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.bioorg.2016.10.002","volume":"69","author":"Ahmad","year":"2016","journal-title":"Bioorg Chem"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.bioorg.2017.01.004","volume":"70","author":"Sarfraz","year":"2017","journal-title":"Bioorg Chem"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"112986","DOI":"10.1016\/j.ejmech.2020.112986","author":"Bibi","year":"2020","journal-title":"Eur J Med Chem"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/1472-6882-12-244","volume":"12","author":"Shah","year":"2012","journal-title":"BMC Complement Altern Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3389\/fphar.2018.00623","volume":"9","author":"Sadiq","year":"2018","journal-title":"Front Pharmacol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/1472-6882-14-181","volume":"14","author":"Shah","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.2147\/DDDT.S140626","volume":"11","author":"Rahim","year":"2017","journal-title":"Drug Des Devel Ther"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3389\/fphar.2016.00200","volume":"7","author":"Zeb","year":"2016","journal-title":"Front Pharmacol"},{"key":"ref37","first-page":"2020","volume":"30","author":"Underwood","year":"2013","journal-title":"Retrieved on March"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"103216","DOI":"10.1016\/j.bioorg.2019.103216","volume":"92","author":"Ahmad","year":"2019","journal-title":"Bioorg Chem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.bioorg.2017.04.009","volume":"72","author":"Sultana","year":"2017","journal-title":"Bioorg Chem"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0166-2236(03)00123-1","volume":"26","author":"Craig","year":"2003","journal-title":"Trends Neurosci"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/j.1533-2500.2012.00564.x","volume":"13","author":"Miljanich","year":"2013","journal-title":"Pain Pract"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/10454411000110010401","volume":"11","author":"Sessle","year":"2000","journal-title":"Crit Rev Oral Biol Med"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1056\/NEJM197204132861504","volume":"286","author":"Moertel","year":"1972","journal-title":"N Engl J Med"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0304-3959(92)90003-T","volume":"51","author":"Tj\u00f8lsen","year":"1992","journal-title":"Pain"},{"key":"ref45","volume-title":"Non-Clinical Safety Studies for the Conduct of Human Clinical Trials for Pharmaceuticals: ICH M3 and M3 (R2). In Global Approach in Safety Testing","year":"2013"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3389\/fchem.2017.00119","volume":"5","author":"Mahmood","year":"2017","journal-title":"Front Chem"},{"key":"ref47","first-page":"8","volume":"6","author":"Patil","year":"2014","journal-title":"Int J Pharm Pharm Sci"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep38128","volume":"6","author":"Yadav","year":"2016","journal-title":"Sci Rep"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.2174\/1568026615666150317222059","volume":"15","author":"Gaur","year":"2015","journal-title":"Curr Top Med Chem"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.ejmech.2014.09.033","volume":"86","author":"Sathish Kumar","year":"2014","journal-title":"Eur J Med Chem"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=67915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=67915","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T19:51:36Z","timestamp":1616442696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/synthesis-of-michael-adducts-as-key-building-blocks-for-potential-anal-peer-reviewed-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":50,"URL":"https:\/\/doi.org\/10.2147\/dddt.s292826","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}