{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:28:30Z","timestamp":1777307310753,"version":"3.51.4"},"reference-count":74,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s299401","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T23:01:55Z","timestamp":1617922915000},"page":"1495-1507","source":"Crossref","is-referenced-by-count":15,"title":["Pharmaceutical Development of 5-Fluorouracil-Eluting Stents for the Potential Treatment of Gastrointestinal Cancers and Related Obstructions"],"prefix":"10.2147","volume":"Volume 15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-5149","authenticated-orcid":true,"given":"Mohammad","family":"Arafat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0008-5895","authenticated-orcid":true,"given":"Yunmei","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paris","family":"Fouladian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankit","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Blencowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-2629","authenticated-orcid":true,"given":"Sanjay","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.jconrel.2019.07.001","volume":"308","author":"Arafat","year":"2019","journal-title":"J Controlled Release"},{"key":"ref2","unstructured":"European Medicines Agency. EMEA\/CHMP\/EWP\/110540\/2007. Guideline on the clinical and non clinical evaluation during the consultation procedure on medicinal substances contained in drug-eluting (medicinal substance-eluting) coronary stents. Available from: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2009\/09\/WC500003275.pdf. Accessed July 15, 2017."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1517\/17425247.2011.572068","volume":"8","author":"Guo","year":"2011","journal-title":"Expert Opin Drug Deliv"},{"key":"ref4","unstructured":"Baron TH Enteral stents for the management of malignant colorectal obstruction. Available from: https:\/\/www.uptodate.com\/contents\/enteral-stents-for-the-management-of-malignant-colorectal-obstruction?source=search_result&search=enteral%20stent&selectedTitle=2~22. Accessed June 30, 2017."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1586\/17434440.3.3.297","volume":"3","author":"Boam","year":"2006","journal-title":"Expert Rev Med Devices"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1016\/j.biomaterials.2005.11.031","volume":"27","author":"Wu","year":"2006","journal-title":"Biomaterials"},{"key":"ref7","volume-title":"Catheter-Based Cardiovascular Interventions: A Knowledge-Based Approach","year":"2013"},{"key":"ref8","unstructured":"Food and Drug Administration Center for Devices and Radiological Health (CDRH). Guidance for Industry: Coronary Drug-Eluting Stents-Nonclinical and Clinical Studies (Draft). Rockville, MD, USA: Food and Drug Administration (FDA); 2008:89."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/s10544-014-9894-9","volume":"16","author":"Kim","year":"2014","journal-title":"Biomed Microdevices"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"7669","DOI":"10.2147\/IJN.S141920","volume":"12","author":"Kwak","year":"2017","journal-title":"Int J Nanomedicine"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/S0016-5107(04)02570-2","volume":"61","author":"Lee","year":"2005","journal-title":"Gastrointest Endosc"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.ijpharm.2012.02.016","volume":"427","author":"Lee","year":"2012","journal-title":"Int J Pharm"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1016\/j.biomaterials.2011.01.070","volume":"32","author":"Moon","year":"2011","journal-title":"Biomaterials"},{"key":"ref14","unstructured":"Clark JW, Grothey A Systemic chemotherapy for metastatic colorectal cancer. Available from: https:\/\/www.uptodate.com\/contents\/systemic-chemotherapy-for-metastatic-colorectal-cancer-completed-clinical-trials\/print?source=see_link. Accessed July 3, 2017."},{"key":"ref15","volume-title":"Current Cancer Treatment - Novel Beyond Conventional Approaches","year":"2011"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ijpharm.2013.07.005","volume":"454","author":"Thipparaboina","year":"2013","journal-title":"Int J Pharm"},{"key":"ref17","unstructured":"National Cancer Institute. Drugs Approved for colon and rectal cancer. https:\/\/www.cancer.gov\/about-cancer\/treatment\/drugs\/colorectal. Available from: Accessed July 3, 2017."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.jconrel.2006.12.030","volume":"118","author":"Guo","year":"2007","journal-title":"J Controlled Release"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1002\/jps.22066","volume":"99","author":"Guo","year":"2010","journal-title":"J Pharm Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"9451","DOI":"10.1016\/j.biomaterials.2013.08.055","volume":"34","author":"Li","year":"2013","journal-title":"Biomaterials"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.4236\/jbnb.2012.34048","volume":"3","author":"Olukman","year":"2012","journal-title":"J Biomater Nanobiotechnol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"6625","DOI":"10.1039\/D0BM01355B","volume":"8","author":"Fouladian","year":"2020","journal-title":"Biomater Sci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.biomaterials.2015.03.009","volume":"53","author":"Liu","year":"2015","journal-title":"Biomaterials"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.gie.2015.02.034","volume":"82","author":"Wang","year":"2015","journal-title":"Gastrointest Endosc"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1177\/1932296813517058","volume":"8","author":"Armstrong","year":"2014","journal-title":"J Diabetes Sci Technol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"263","DOI":"10.2147\/vhrm.2005.1.4.263","volume":"1","author":"Htay","year":"2005","journal-title":"Vasc Health Risk Manag"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"755","DOI":"10.3390\/polym6030755","volume":"6","author":"Kwon","year":"2014","journal-title":"Polymers"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.biomaterials.2006.11.042","volume":"28","author":"Mani","year":"2007","journal-title":"Biomaterials"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e002943","DOI":"10.1161\/CIRCINTERVENTIONS.115.002943","volume":"9","author":"Rizas Konstantinos","year":"2016","journal-title":"Circ Cardiovasc Interv"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1177\/000456328001700510","volume":"17","author":"Hsu","year":"1980","journal-title":"Ann Clin Biochem"},{"key":"ref31","unstructured":"Chappa RA, Hergenrother RW, Wadman SA, Wormuth KR Coating systems for the controlled delivery of hydrophilic bioactive agents. Google Patents; 2013."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3390\/pharmaceutics13010017","volume":"13","author":"Arafat","year":"2021","journal-title":"Pharmaceutics"},{"key":"ref33","unstructured":"United States Pharmacopeial Convention. Fluorouracil. United States Pharmacopeial Convention; 2019."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"651","DOI":"10.3390\/ma10060651","volume":"10","author":"Freire","year":"2017","journal-title":"Materials"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1208\/s12248-010-9185-1","volume":"12","author":"Zhang","year":"2010","journal-title":"AAPS J"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"204925","DOI":"10.1155\/2014\/204925","volume":"2014","author":"Zuo","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ejpb.2016.01.015","volume":"101","author":"Shaikh","year":"2016","journal-title":"Eur J Pharm Biopharmaceutics"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0378-5173(00)00554-8","volume":"209","author":"Yuksel","year":"2000","journal-title":"Int J Pharm"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/j.1440-1746.2011.06866.x","volume":"27","author":"Chung","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1055\/s-0032-1309881","volume":"44","author":"Jang","year":"2012","journal-title":"Endoscopy"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.gie.2008.08.005","volume":"69","author":"Lee","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2055-7124-18-15","volume":"18","author":"Seo","year":"2014","journal-title":"Biomater Res"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jconrel.2010.05.017","volume":"146","author":"Lei","year":"2010","journal-title":"J Controlled Release"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1115\/1.4023414","volume":"7","author":"Thakkar","year":"2013","journal-title":"J Med Device"},{"key":"ref45","unstructured":"Whitbourne RJ, Chamberlain AM, Hullihen DG, Rosebrough SF, Calistri-Yeh M Medicated stent having multi-layer polymer coating. Google Patents; 2012."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jpba.2018.03.021","volume":"154","author":"Amasya","year":"2018","journal-title":"J Pharm Biomed Anal"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1590\/S1984-82502013000100013","volume":"49","author":"Mattos","year":"2013","journal-title":"Br J Pharm Sci"},{"key":"ref48","unstructured":"United States Pharmacopeial Convention. (1225) Validation of Compendial Procedures. United States Pharmacopeial Convention; 2019."},{"key":"ref49","first-page":"05","author":"Zafar","year":"2014","journal-title":"J Chromatography Separation Tech"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"401629","DOI":"10.1155\/2013\/401629","volume":"2013","author":"Sanganal","year":"2013","journal-title":"ISRN Chromatography"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1111\/jedm.12046","volume":"15","author":"Chan","year":"2017","journal-title":"Vet Comp Oncol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"34","DOI":"10.4212\/cjhp.v62i1.115","volume":"62","author":"Galanti","year":"2009","journal-title":"Can J Hosp Pharm"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0959-8049(93)90590-C","volume":"29","author":"Milano","year":"1993","journal-title":"Eur J Cancer"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/BF00685544","volume":"31","author":"Williams","year":"1992","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref55","first-page":"224","volume":"10","author":"Ibrahim","year":"2018","journal-title":"Nano Biomed Eng"},{"key":"ref56","first-page":"74","volume":"87","author":"Charalambides","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/gut.29.8.1035","volume":"29","author":"Evans","year":"1988","journal-title":"Gut"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1007\/BF01316512","volume":"38","author":"McDougall","year":"1993","journal-title":"Dig Dis Sci"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1136\/gut.31.12.1355","volume":"31","author":"Pye","year":"1990","journal-title":"Gut"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1208\/s12249-015-0328-7","volume":"16","author":"Chinembiri","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"ref61","volume-title":"Formulation of 5-Fluorouracil for Transdermal Delivery","year":"2010"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S1773-2247(12)50050-X","volume":"22","author":"Shin","year":"2012","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.ejpb.2011.12.006","volume":"80","author":"Bege","year":"2012","journal-title":"Eur J Pharm Biopharmaceutics"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1002\/jbm.b.31919","volume":"100B","author":"Mc Conville","year":"2012","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jconrel.2011.11.031","volume":"159","author":"Wolinsky","year":"2012","journal-title":"J Control Release"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.gii.2015.03.004","volume":"4","author":"Jang","year":"2015","journal-title":"Gastrointestinal Intervent"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.2147\/IJN.S43508","volume":"8","author":"Kim","year":"2013","journal-title":"Int J Nanomedicine"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"16885","DOI":"10.1039\/C4RA01300J","volume":"4","author":"Zhao","year":"2014","journal-title":"RSC Adv"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/3486384","volume":"2017","author":"KobryD","year":"2017","journal-title":"Int J Polym Sci"},{"key":"ref70","volume-title":"Handbook of Organic Solvent Properties","year":"1996"},{"key":"ref71","unstructured":"United States Pharmacopeial Convention. Residual Solvents; 2019. Available from: https:\/\/www.uspnf.com\/sites\/default\/files\/usp_pdf\/EN\/USPNF\/revisions\/gc-467-residual-solvents-ira-20190927.pdf. Accessed January 30, 2020."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"274","DOI":"10.7150\/ijms.22644","volume":"15","author":"Harrell","year":"2018","journal-title":"Int J Med Sci"},{"key":"ref73","unstructured":"ICH Harmonised Tripartite Guideline. Stability testing of new drug substances and products Q1A(R2). Available from: https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/ich-q-1-r2-stability-testing-new-drug-substances-products-step-5_en.pdf. Accessed February 23, 2020."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jddst.2016.05.006","volume":"35","author":"Kamberi","year":"2016","journal-title":"J Drug Deliv Sci Technol"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=68321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=68321","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T23:02:15Z","timestamp":1617922935000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/pharmaceutical-development-of-5-fluorouracil-eluting-stents-for-the-po-peer-reviewed-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":74,"URL":"https:\/\/doi.org\/10.2147\/dddt.s299401","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}