{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:43:17Z","timestamp":1789177397896,"version":"build-2803163510"},"reference-count":20,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s308610","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:46:32Z","timestamp":1625532392000},"page":"2947-2959","source":"Crossref","is-referenced-by-count":14,"title":["A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Hongjie","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huahua","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9679-9934","authenticated-orcid":true,"given":"Jingshan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9450-2260","authenticated-orcid":true,"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-3219","authenticated-orcid":true,"given":"Jingying","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nrcardio.2011.87","volume":"8","author":"Schermuly","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1801887","DOI":"10.1183\/13993003.01887-2018","volume":"53","author":"Humbert","year":"2019","journal-title":"Eur Respir J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"D60","DOI":"10.1016\/j.jacc.2013.10.031","volume":"62","author":"Gali\u00e8","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1056\/NEJMoa050010","volume":"353","author":"Gali\u00e8","year":"2005","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1161\/CIRCULATIONAHA.108.839274","volume":"119","author":"Gali\u00e8","year":"2009","journal-title":"Circulation"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1056\/NEJMoa1213917","volume":"369","author":"Pulido","year":"2013","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1002\/phar.1592","volume":"35","author":"Makowski","year":"2015","journal-title":"Pharmacotherapy"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"15153","DOI":"10.1021\/acs.jmedchem.0c01093","volume":"63","author":"Zheng","year":"2020","journal-title":"J Med Chem"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","volume":"329","author":"Moncada","year":"1993","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"L536","DOI":"10.1152\/ajplung.1994.266.5.L536","volume":"266","author":"Rabe","year":"1994","journal-title":"Am J Physiol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"L1366","DOI":"10.1152\/ajplung.00273.2001","volume":"282","author":"Jernigan","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1164\/rccm.200411-1587OC","volume":"172","author":"Wharton","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"4979","DOI":"10.1021\/acs.jmedchem.9b00123","volume":"62","author":"Wang","year":"2019","journal-title":"J Med Chem"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"113634","DOI":"10.1016\/j.jpba.2020.113634","volume":"191","author":"Zhang","year":"2020","journal-title":"J Pharm Biomed Anal"},{"key":"ref15","unstructured":"Guidance for Industry: Food-Effect Bioavailability and Fed Bioequivalence Studies. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER); 2002. Available from: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/food-effect-bioavailability-and-fed-bioequivalence-studies. Accessed July 02, 2021."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1177\/0091270005276847","volume":"45","author":"Gupta","year":"2005","journal-title":"J Clin Pharmacol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"5S","DOI":"10.1046\/j.0306-5251.2001.00027.x","volume":"53","author":"Nichols","year":"2002","journal-title":"Br J Clin Pharmacol"},{"key":"ref18","first-page":"17","volume":"10","author":"Brock","year":"2003","journal-title":"Can J Urol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1038\/sj.ijir.3901208","volume":"16","author":"Bischoff","year":"2004","journal-title":"Int J Impot Res"},{"key":"ref20","unstructured":"VIAGRA\u00ae\u00a0(sildenafil citrate) tablets [prescribing information]. U.S.; December,\u00a02017.\u00a0"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=71340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=71340","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:46:41Z","timestamp":1625532401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/a-phase-i-study-to-evaluate-the-safety-tolerability-and-pharmacokineti-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":20,"URL":"https:\/\/doi.org\/10.2147\/dddt.s308610","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}