{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:20:22Z","timestamp":1792549222687,"version":"4.5.0"},"reference-count":40,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s309648","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T18:24:27Z","timestamp":1622571867000},"page":"2357-2373","source":"Crossref","is-referenced-by-count":25,"title":["Topical Delivery of Levocarnitine to the Cornea and Anterior Eye by Thermosensitive in-situ Gel for Dry Eye Disease"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Baorui","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linnuo","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-1626","authenticated-orcid":true,"given":"Xingbin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhai","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"ref1","author":"Holland","year":"2013","journal-title":"Elsevier Health Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1155\/2014\/748654","volume":"2014","author":"Liu","year":"2014","journal-title":"J Ophthalmol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"405","DOI":"10.2147\/OPTH.S5555","volume":"3","author":"Gayton","year":"2009","journal-title":"Clin Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.preteyeres.2004.04.003","volume":"23","author":"Johnson","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul Surf"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul Surf"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1159\/000363043","volume":"34","author":"Khajavi","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3109\/02713683.2014.957776","volume":"40","author":"Hua","year":"2015","journal-title":"Curr Eye Res"},{"key":"ref11","first-page":"330","volume":"48","author":"Huo","year":"2012","journal-title":"Chin J Opthalmol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1177\/1120672118769776","volume":"29","author":"Bhattacharjee","year":"2019","journal-title":"Eur J Ophthalmol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.3390\/ma11071125","volume":"11","author":"Choi","year":"2018","journal-title":"Materials"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.5497\/wjp.v2.i2.47","volume":"2","author":"Patel","year":"2013","journal-title":"World J Pharmacol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"6988","DOI":"10.1039\/D0PY00919A","volume":"11","author":"Nguyen","year":"2020","journal-title":"Polym Chem"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ajps.2018.04.008","volume":"14","author":"Wu","year":"2019","journal-title":"Asian J Pharm Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.lfs.2019.02.029","volume":"21","author":"Yadav","year":"2019","journal-title":"Life Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"126190","DOI":"10.1016\/j.cej.2020.126190","volume":"402","author":"Lai","year":"2020","journal-title":"Chem Eng J"},{"key":"ref19","first-page":"225","volume":"29","author":"Pengcheng","year":"2013","journal-title":"J Guangdong Pharm Univ"},{"key":"ref20","first-page":"177","volume":"17","author":"Nan","year":"2015","journal-title":"Chin J Med Guide"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"5580","DOI":"10.1039\/C9NR00376B","volume":"11","author":"Li","year":"2019","journal-title":"Nanoscale"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"111095","DOI":"10.1016\/j.msec.2020.111095","volume":"15","author":"Luo","year":"2020","journal-title":"Mater Sci Eng C"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-016-0028-x","volume":"7","author":"Luo","year":"2017","journal-title":"Sci Rep"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"6287","DOI":"10.1167\/iovs.13-12081","volume":"54","author":"Chen","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.clae.2017.11.004","volume":"41","author":"Acar","year":"2018","journal-title":"Cont Lens Anterior Eye"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"5745","DOI":"10.2147\/IJN.S254792","volume":"5","author":"Kwon","year":"2020","journal-title":"Int J Nanomedicine"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.biomaterials.2004.04.030","volume":"26","author":"Hiratani","year":"2005","journal-title":"Biomaterials"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1089\/jop.2004.20.548","volume":"20","author":"Camillieri","year":"2004","journal-title":"J Ocul Pharmacol Th"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1136\/bjo.2003.027573","volume":"88","author":"Gomes","year":"2004","journal-title":"Briti J Ophthalmol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.actbio.2013.12.019","volume":"10","author":"Dicker","year":"2014","journal-title":"Acta Biomater"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"123","DOI":"10.14573\/altex.1510053","volume":"33","author":"Thomas","year":"2016","journal-title":"Altex"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.exer.2009.03.015","volume":"89","author":"Chen","year":"2009","journal-title":"Exp Eye Res"},{"key":"ref33","first-page":"1243","volume":"20","author":"Deng","year":"2014","journal-title":"Mol Vis"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"5503","DOI":"10.1167\/iovs.14-16247","volume":"56","author":"Hua","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref35","first-page":"1684","volume":"37","author":"Inatomi","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.proghi.2006.03.001","volume":"41","author":"Paulsen","year":"2006","journal-title":"Prog Histochem Cytochem"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"23037","DOI":"10.1074\/jbc.M109.033332","volume":"284","author":"Arg\u00fceso","year":"2009","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jtos.2014.01.004","volume":"12","author":"Ya\u00f1Ez-Soto","year":"2014","journal-title":"Ocul Surf"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.preteyeres.2018.11.007","volume":"1","author":"Baudouin","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/00004397-197301310-00013","volume":"13","author":"Lemp","year":"1973","journal-title":"Int Ophthalmol Clin"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=70122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=70122","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T18:24:38Z","timestamp":1622571878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/topical-delivery-of-levocarnitine-to-the-cornea-and-anterior-eye-by-th-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":40,"URL":"https:\/\/doi.org\/10.2147\/dddt.s309648","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}