{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:35:01Z","timestamp":1792859701052,"version":"4.5.0"},"reference-count":31,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s309964","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T15:00:08Z","timestamp":1626706808000},"page":"3181-3191","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of Clinical Trials of New Drugs for Liver Diseases in China"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Longfei","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1093\/jnci\/djn120","volume":"100","author":"McBride","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.14218\/JCTH.2013.00030","volume":"2","author":"Yan","year":"2014","journal-title":"J Clin Transl Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.mehy.2017.08.005","volume":"108","author":"Zhou","year":"2017","journal-title":"Med Hypotheses"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1056\/NEJMra031087","volume":"350","author":"Ganem","year":"2004","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s13045-019-0783-9","volume":"12","author":"Lin","year":"2019","journal-title":"J Hematol Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1159\/000508568","volume":"9","author":"Lin","year":"2020","journal-title":"Liver Cancer"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/MJT.0b013e318155a191","volume":"15","author":"Palumbo","year":"2008","journal-title":"Am J Ther"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"S172","DOI":"10.1016\/S0168-8278(03)00334-9","volume":"39","author":"Hadziyannis","year":"2003","journal-title":"J Hepatol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/s41573-019-0037-0","volume":"18","author":"Fanning","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3109\/08830185.2013.774391","volume":"32","author":"Sasai","year":"2013","journal-title":"Int Rev Immunol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.jhep.2017.10.027","volume":"68","author":"Janssen","year":"2018","journal-title":"J Hepatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1055\/s-2002-35695","volume":"22","author":"Manns","year":"2002","journal-title":"Semin Liver Dis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"941","DOI":"10.2169\/internalmedicine.42.941","volume":"42","author":"Arase","year":"2003","journal-title":"Intern Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1002\/jps.10401","volume":"92","author":"Saruc","year":"2003","journal-title":"J Pharm Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"283","DOI":"10.2217\/fvl.14.113","volume":"10","author":"Clark","year":"2015","journal-title":"Future Virol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"110053","DOI":"10.1016\/j.biopha.2020.110053","volume":"126","author":"Liu","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1146\/annurev-pharmtox-011112-140254","volume":"53","author":"Kiser","year":"2013","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.pharmthera.2017.10.009","volume":"183","author":"Spengler","year":"2018","journal-title":"Pharmacol Ther"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1517\/14656566.2013.795543","volume":"14","author":"Soriano","year":"2013","journal-title":"Expert Opin Pharmacother"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/jvh.12657","volume":"24","author":"Gitto","year":"2017","journal-title":"J Viral Hepat"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01237-19","volume":"63","author":"Tao","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1016\/j.drudis.2020.09.030","volume":"25","author":"Lin","year":"2020","journal-title":"Drug Discov Today"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"A 4-drug combination (Viekira Pak) for hepatitis C. JAMA. 2015;313:1857\u20131858.","DOI":"10.1001\/jama.2015.4562"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/nrd3214","volume":"9","author":"Opar","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1056\/NEJMoa1402355","volume":"370","author":"Kowdley","year":"2014","journal-title":"N Engl J Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1478-3231.2011.02716.x","volume":"32","author":"Halfon","year":"2012","journal-title":"Liver Int"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.3389\/fphar.2019.01331","volume":"10","author":"Zhang","year":"2019","journal-title":"Front Pharmacol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.4014\/jmb.1701.01077","volume":"27","author":"Song","year":"2017","journal-title":"J Microbiol Biotechnol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s12185-013-1317-9","volume":"97","author":"Li","year":"2013","journal-title":"Int J Hematol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e23720","DOI":"10.1371\/journal.pone.0023720","volume":"6","author":"Zhu","year":"2011","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1002\/eji.201948225","volume":"49","author":"Hao","year":"2019","journal-title":"Eur J Immunol"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=71856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=71856","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T15:00:12Z","timestamp":1626706812000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/analysis-of-clinical-trials-of-new-drugs-for-liver-diseases-in-china-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":31,"URL":"https:\/\/doi.org\/10.2147\/dddt.s309964","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}