{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:39:28Z","timestamp":1787024368708,"version":"build-2736575974"},"reference-count":55,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s316701","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T14:20:08Z","timestamp":1626704408000},"page":"3193-3206","source":"Crossref","is-referenced-by-count":35,"title":["A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Jiuling","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-5156","authenticated-orcid":true,"given":"Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doudou","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wansheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s11655-008-0207-2","volume":"14","author":"Zhao","year":"2008","journal-title":"Chin J Integr Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s10787-010-0062-4","volume":"19","author":"Chan","year":"2011","journal-title":"Inflammopharmacology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"112361","DOI":"10.1016\/j.jep.2019.112361","volume":"248","author":"Hu","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"4127","DOI":"10.1021\/ol701540y","volume":"9","author":"Liu","year":"2007","journal-title":"Org Lett"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1142\/S0192415X1350050X","volume":"41","author":"Zhou","year":"2013","journal-title":"Am J Chin Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1078\/09447110260571661","volume":"9","author":"Ho","year":"2002","journal-title":"Phytomedicine"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"112550","DOI":"10.1016\/j.jep.2020.112550","volume":"251","author":"Nie","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"320","DOI":"10.7538\/zpxb.youxian.2016.0057","volume":"38","author":"Yan","year":"2017","journal-title":"J Chin Mass Spectromet Soc"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s10753-009-9164-9","volume":"33","author":"Shin","year":"2010","journal-title":"Inflammation"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010116","volume":"22","author":"Li","year":"2017","journal-title":"Molecules"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1089\/jmf.2019.4476","volume":"23","author":"Ruan","year":"2020","journal-title":"J Med Food"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jep.2014.09.005","volume":"157","author":"Xiao","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"5601","DOI":"10.2147\/DDDT.S89924","volume":"9","author":"Jiang","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"ref14","first-page":"6","volume":"27","author":"Yang","year":"2011","journal-title":"Chin J Virol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1002\/jssc.201301159","volume":"37","author":"Zhang","year":"2014","journal-title":"J Sep Sci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"20906","DOI":"10.3390\/molecules191220906","volume":"19","author":"He","year":"2014","journal-title":"Molecules"},{"key":"ref17","first-page":"1172","volume":"38","author":"Wang","year":"2013","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"112782","DOI":"10.1016\/j.jep.2020.112782","volume":"257","author":"Wang","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1142\/S0192415X1350064X","volume":"41","author":"Deng","year":"2013","journal-title":"Am J Chin Med"},{"key":"ref20","first-page":"430","volume":"38","author":"Li","year":"2003","journal-title":"Yao Xue Xue Bao"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.3390\/molecules23061305","volume":"23","author":"Shi","year":"2018","journal-title":"Molecules"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1007\/s11418-021-01506-0","volume":"75","author":"Hou","year":"2021","journal-title":"J Nat Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"72","DOI":"10.7150\/ijbs.13188","volume":"12","author":"Lv","year":"2016","journal-title":"Int J Biol Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.3892\/mmr.2019.9909","volume":"19","author":"Xiao","year":"2019","journal-title":"Mol Med Rep"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1002\/ijc.25909","volume":"129","author":"Zhang","year":"2011","journal-title":"Int J Cancer"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"126552","DOI":"10.1016\/j.jtemb.2020.126552","volume":"61","author":"Aqeel","year":"2020","journal-title":"J Trace Elem Med Biol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/nbt1007-1110","volume":"25","author":"Hopkins","year":"2007","journal-title":"Nat Biotechnol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1189\/jlb.3MR0316-118RR","volume":"101","author":"Seeley","year":"2017","journal-title":"J Leukoc Biol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1016\/j.addr.2013.05.013","volume":"65","author":"Hafner","year":"2013","journal-title":"Adv Drug Deliv Rev"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci Rep"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"W357","DOI":"10.1093\/nar\/gkz382","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"7395238","DOI":"10.1155\/2017\/7395238","volume":"2017","author":"Pietrofesa","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408398.2020.1784840","author":"Chhillar","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.fitote.2016.09.011","volume":"115","author":"He","year":"2016","journal-title":"Fitoterapia"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1 30 1","DOI":"10.1002\/cpbi.5","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr Protoc Bioinformatics"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.pharmthera.2003.08.003","volume":"100","author":"Fujihara","year":"2003","journal-title":"Pharmacol Ther"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"888","DOI":"10.3892\/ijmm.2017.3296","volume":"41","author":"Lee","year":"2018","journal-title":"Int J Mol Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"5653","DOI":"10.4049\/jimmunol.1102144","volume":"187","author":"Hasan","year":"2011","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"103580","DOI":"10.1016\/j.micpath.2019.103580","volume":"134","author":"Tariq","year":"2019","journal-title":"Microb Pathog"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3390\/plants9040453","volume":"9","author":"Trong Le","year":"2020","journal-title":"Plants (Basel)"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9040207","volume":"9","author":"Trong Le","year":"2020","journal-title":"Antibiotics (Basel)"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14786419.2020.1824228","author":"Sanna","year":"2020","journal-title":"Nat Prod Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.3855\/jidc.12469","volume":"14","author":"Le","year":"2020","journal-title":"J Infect Dev Ctries"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.tim.2015.08.001","volume":"23","author":"Lee","year":"2015","journal-title":"Trends Microbiol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.biopha.2017.10.145","volume":"97","author":"Sowndhararajan","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.bcp.2003.08.020","volume":"67","author":"Mak","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/v13010047","volume":"13","author":"Chen","year":"2020","journal-title":"Viruses"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1128\/MMBR.05015-11","volume":"76","author":"Tisoncik","year":"2012","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.immuni.2013.05.007","volume":"38","author":"Goubau","year":"2013","journal-title":"Immunity"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"111901","DOI":"10.1016\/j.jep.2019.111901","volume":"239","author":"Xu","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"3634","DOI":"10.3390\/ijms19113634","volume":"19","author":"Cui","year":"2018","journal-title":"Int J Mol Sci"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jep.2019.02.040","volume":"237","author":"Zhang","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","volume":"137","author":"Cho","year":"2009","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature09782","volume":"469","author":"Levine","year":"2011","journal-title":"Nature"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=71867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=71867","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T14:20:16Z","timestamp":1626704416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/a-network-pharmacology-based-investigation-to-the-pharmacodynamic-mate-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":55,"URL":"https:\/\/doi.org\/10.2147\/dddt.s316701","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}