{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:38:45Z","timestamp":1791236325535,"version":"4.1.0"},"reference-count":66,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s323107","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T11:50:20Z","timestamp":1631706620000},"page":"3927-3936","source":"Crossref","is-referenced-by-count":36,"title":["Umbilical Cord Mesenchymal Stem Cell Therapy for Regenerative Treatment of Rheumatoid Arthritis: Opportunities and Challenges"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Xiaolan","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoRong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9157-9964","authenticated-orcid":true,"given":"Shigao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"101477","DOI":"10.1016\/j.berh.2019.101477","volume":"33","author":"Ot\u00f3n","year":"2019","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1097\/00002281-200207000-00013","volume":"14","author":"Goldring","year":"2002","journal-title":"Curr Opin Rheumatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3899\/jrheum.170710","volume":"45","author":"Subesinghe","year":"2018","journal-title":"J Rheumatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.berh.2008.11.004","volume":"23","author":"El-Gabalawy","year":"2009","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3389\/fcell.2020.00138","volume":"8","author":"Chang","year":"2020","journal-title":"Front Cell Develop Biol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3389\/fimmu.2019.00266","volume":"10","author":"Ross","year":"2019","journal-title":"Front Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"4331","DOI":"10.2147\/DDDT.S225613","volume":"13","author":"Wang","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1089\/scd.2013.0023","volume":"22","author":"Wang","year":"2013","journal-title":"Stem Cells Dev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.3390\/cells9081852","volume":"9","author":"Lopez-Santalla","year":"2020","journal-title":"Cells"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"602647","DOI":"10.3389\/fcell.2020.602647","volume":"8","author":"Coelho","year":"2020","journal-title":"Front Cell Develop Biol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e340","DOI":"10.1097\/MD.0000000000000340","volume":"93","author":"Wang","year":"2014","journal-title":"Medicine"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003789.pub2","author":"Wienecke","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"ref13","first-page":"3395","volume":"62","author":"Tiano","year":"2002","journal-title":"Cancer Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1056\/NEJMoa0706290","volume":"359","author":"Lovell","year":"2008","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1136\/annrheumdis-2016-209201","volume":"75","author":"Schett","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1517\/13543780902832679","volume":"18","author":"Castillo","year":"2009","journal-title":"Expert Opin Investig Drugs"},{"key":"ref17","first-page":"1","volume":"15","author":"Song","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/1756-185X.12659","volume":"19","author":"Downey","year":"2016","journal-title":"J Rheum Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/art.21678","volume":"54","author":"Smolen","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1002\/art.20568","volume":"50","author":"St. Clair","year":"2004","journal-title":"Arthritis Rheum"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/ard.2006.065615","volume":"66","author":"Bartelds","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.f1939","volume":"346","author":"Raaschou","year":"2013","journal-title":"BMJ"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"3738","DOI":"10.3390\/ijms20153738","volume":"20","author":"Vizoso","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-1105-9","volume":"10","author":"Chen","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"362","DOI":"10.2174\/1574888X13666180403163456","volume":"13","author":"Li","year":"2018","journal-title":"Curr Stem Cell Res Ther"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"5251313","DOI":"10.1155\/2017\/5251313","volume":"2017","author":"Qu","year":"2017","journal-title":"Stem Cells Int"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"6518508","DOI":"10.1155\/2020\/6518508","volume":"2020","author":"Zhou","year":"2020","journal-title":"Stem Cells Int"},{"key":"ref28","first-page":"721","volume":"35","author":"Ferro","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"ref29","first-page":"519","volume":"37","author":"Silvagni","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00281-017-0623-3","volume":"39","author":"Cheung","year":"2017","journal-title":"Semin Immunopathol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.ebiom.2019.04.058","volume":"43","author":"Luo","year":"2019","journal-title":"EBioMedicine"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"798","DOI":"10.3389\/fimmu.2019.00798","volume":"10","author":"Luque-Campos","year":"2019","journal-title":"Front Immunol"},{"key":"ref33","first-page":"911","volume":"36","author":"Liu","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3390\/cells8080823","volume":"8","author":"Haikal","year":"2019","journal-title":"Cells"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.7150\/ijbs.25306","volume":"14","author":"Li","year":"2018","journal-title":"Int J Biol Sci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.semarthrit.2016.02.008","volume":"46","author":"Hynes","year":"2016","journal-title":"Semin Arthritis Rheum"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/stem.3016","volume":"37","author":"Andrzejewska","year":"2019","journal-title":"Stem Cells"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"R210","DOI":"10.1186\/ar3187","volume":"12","author":"Liu","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3389\/fvets.2017.00084","volume":"4","author":"Berglund","year":"2017","journal-title":"Front Vet Sci"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1634\/stemcells.2006-0286","volume":"25","author":"Karahuseyinoglu","year":"2007","journal-title":"Stem Cells"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/1471-2474-13-249","volume":"13","author":"Wang","year":"2012","journal-title":"BMC Musculoskelet Disord"},{"key":"ref42","first-page":"166","volume":"22","author":"Gu","year":"2014","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jocit.2014.12.001","volume":"2","author":"Zhao","year":"2016","journal-title":"J Cell Immunother"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e867","DOI":"10.1002\/term.2400","volume":"12","author":"Shou","year":"2018","journal-title":"J Tissue Eng Regen Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3390\/cells8080784","volume":"8","author":"Fu","year":"2019","journal-title":"Cells"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s13287-021-02227-7","volume":"12","author":"Chen","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s13287-017-0716-x","volume":"8","author":"Xu","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"447","DOI":"10.2174\/1574888X12666170502102423","volume":"12","author":"Zhang","year":"2017","journal-title":"Curr Stem Cell Res Ther"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1177\/0963689718805383","volume":"27","author":"Song","year":"2018","journal-title":"Cell Transplant"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1111\/j.1524-475X.2007.00221.x","volume":"15","author":"Wu","year":"2007","journal-title":"Wound Repair Regen"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1080\/14653240802345820","volume":"10","author":"Herdrich","year":"2008","journal-title":"Cytotherapy"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.clindermatol.2006.10.002","volume":"25","author":"Cha","year":"2007","journal-title":"Clin Dermatol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00441-008-0724-3","volume":"335","author":"Fu","year":"2009","journal-title":"Cell Tissue Res"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1634\/stemcells.2004-0340","volume":"23","author":"Suh","year":"2005","journal-title":"Stem Cells"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/j.1524-475X.2007.00277.x","volume":"15","author":"Volk","year":"2007","journal-title":"Wound Repair Regen"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5583994","volume":"2021:5583994","author":"Wei","year":"2021","journal-title":"Stem Cell Int"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3389\/fimmu.2015.00560","volume":"6","author":"Mattar","year":"2015","journal-title":"Front Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0028-x","volume":"7","author":"Song","year":"2017","journal-title":"Sci Rep"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4252\/wjsc.v4.i10.101","volume":"4","author":"Greish","year":"2012","journal-title":"World J Stem Cells"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/sctm.18-0031","volume":"7","author":"Park","year":"2018","journal-title":"Stem Cells Transl Med"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e21222","DOI":"10.1097\/MD.0000000000021222","volume":"99","author":"Qi","year":"2020","journal-title":"Medicine"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1002\/art.22511","volume":"56","author":"Augello","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.stem.2011.12.005","volume":"10","author":"Senseb\u00e9","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.jcyt.2015.11.017","volume":"18","author":"Stultz","year":"2016","journal-title":"Cytotherapy"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"147","DOI":"10.2217\/rme.11.113","volume":"7","author":"Duarte","year":"2012","journal-title":"Regen Med"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3233\/BME-141249","volume":"25","author":"Zheng","year":"2015","journal-title":"Biomed Mater Eng"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=73675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=73675","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T11:51:01Z","timestamp":1631706661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/umbilical-cord-mesenchymal-stem-cell-therapy-for-regenerative-treatmen-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":66,"URL":"https:\/\/doi.org\/10.2147\/dddt.s323107","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}