{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:20:11Z","timestamp":1792009211344,"version":"4.4.0"},"reference-count":254,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s329547","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T08:31:23Z","timestamp":1634027483000},"page":"4289-4338","source":"Crossref","is-referenced-by-count":406,"title":["The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Yong","family":"Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-You","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9786-7492","authenticated-orcid":true,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"113218","DOI":"10.1016\/j.ejmech.2021.113218","volume":"214","author":"Wang","year":"2021","journal-title":"Eur J Med Chem"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1021\/cr200251d","volume":"112","author":"Bull","year":"2012","journal-title":"Chem Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/nrd.2018.116","volume":"17","author":"Bostr\u00f6m","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"112915","DOI":"10.1016\/j.ejmech.2020.112915","volume":"209","author":"Wang","year":"2021","journal-title":"Eur J Med Chem"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.3390\/molecules24224161","volume":"24","author":"Jubete","year":"2019","journal-title":"Molecules"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"6037","DOI":"10.1021\/acs.jmedchem.1c00138","volume":"64","author":"Mammoliti","year":"2021","journal-title":"J Med Chem"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"113499","DOI":"10.1016\/j.ejmech.2021.113499","volume":"220","author":"Ran","year":"2021","journal-title":"Eur J Med Chem"},{"key":"ref8","first-page":"39","volume":"1","author":"Yerragunta","year":"2013","journal-title":"PharmaTutor"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1016\/j.bmcl.2016.02.043","volume":"26","author":"Desai","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/B978-0-12-408100-0.00006-9","volume":"110","author":"Comins","year":"2013","journal-title":"Adv Heterocycl Chem"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"115820","DOI":"10.1016\/j.bmc.2020.115820","volume":"28","author":"Lin","year":"2020","journal-title":"Bioorg Med Chem"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1042\/BJ20061638","volume":"402","author":"Pollak","year":"2007","journal-title":"Biochem J"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.1016\/j.tetlet.2011.04.007","volume":"52","author":"Coffinier","year":"2011","journal-title":"Tetrahedron Lett"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1007\/s10593-020-02843-w","volume":"56","author":"Zakharychev","year":"2020","journal-title":"Chem Heterocycl Compd"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1039\/C4QO00187G","volume":"1","author":"Neely","year":"2014","journal-title":"Org Chem Front"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"9763","DOI":"10.1039\/c2ra21406g","volume":"2","author":"Wan","year":"2012","journal-title":"RSC Adv"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2174\/1389557521666210126143558","volume":"21","author":"Alizadeh","year":"2021","journal-title":"Mini Rev Med Chem"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"105374","DOI":"10.1016\/j.ejps.2020.105374","volume":"151","author":"Villamizar-Mogotocoro","year":"2020","journal-title":"Eur J Pharm Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"4901","DOI":"10.2174\/092986711797535173","volume":"18","author":"Ioan","year":"2011","journal-title":"Curr Med Chem"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2174\/1385272821666170207104206","volume":"21","author":"Velena","year":"2017","journal-title":"Curr Org Chem"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"869","DOI":"10.2174\/1389557516666160923125801","volume":"17","author":"Prachayasittikul","year":"2017","journal-title":"Mini Rev Med Chem"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.2174\/092986732311160420104823","volume":"23","author":"\u00c1lvarez","year":"2016","journal-title":"Curr Med Chem"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.phrs.2016.05.017","volume":"113","author":"Klusa","year":"2016","journal-title":"Pharmacol Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1177\/2040622315582353","volume":"6","author":"Peters","year":"2015","journal-title":"Ther Adv Chronic Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s10989-015-9460-1","volume":"21","author":"Lapidot","year":"2015","journal-title":"Int J Pept Res Ther"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/s0828-282x(08)70651-2","volume":"24","author":"Bucci","year":"2008","journal-title":"Can J Cardiol"},{"key":"ref27","doi-asserted-by":"publisher","volume-title":"Bioactive Heterocyclic Compound Classes","year":"2013","DOI":"10.1002\/9783527664450.ch9"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"693","DOI":"10.5551\/jat.12450","volume":"19","author":"Ishii","year":"2012","journal-title":"J Atheroscler Thromb"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.2174\/1389557519666190425184749","volume":"19","author":"Mishra","year":"2019","journal-title":"Mini Rev Med Chem"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"282","DOI":"10.2174\/1389557513666131119204126","volume":"14","author":"Khedkar","year":"2014","journal-title":"Mini Rev Med Chem"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.drudis.2009.08.004","volume":"14","author":"Edraki","year":"2009","journal-title":"Drug Discov Today"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"10257","DOI":"10.1021\/jm501100b","volume":"57","author":"Vitaku","year":"2014","journal-title":"J Med Chem"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"3552","DOI":"10.1021\/acs.jmedchem.6b01807","volume":"60","author":"Pennington","year":"2017","journal-title":"J Med Chem"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1021\/jm700956r","volume":"51","author":"Vanotti","year":"2008","journal-title":"J Med Chem"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"4921","DOI":"10.1021\/jm400186h","volume":"56","author":"Zheng","year":"2013","journal-title":"J Med Chem"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"5070","DOI":"10.1021\/jm200290z","volume":"54","author":"Hong","year":"2011","journal-title":"J Med Chem"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"4165","DOI":"10.1016\/j.bmcl.2016.07.065","volume":"26","author":"Huang","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.2147\/TCRM.S159824","volume":"14","author":"Castellan","year":"2018","journal-title":"Ther Clin Risk Manag"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/j.1365-2125.1992.tb04081.x","volume":"33","author":"Basco","year":"1992","journal-title":"Br J Clin Pharmacol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1042\/bj0960837","volume":"96","author":"Raghuramulu","year":"1965","journal-title":"Biochem J"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1136\/bmj.1.5117.274","volume":"1","author":"Westlake","year":"1959","journal-title":"BMJ"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/0002-9343(93)90390-B","volume":"95","author":"Lister","year":"1993","journal-title":"Am J Med"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1001\/jama.1984.03340340023018","volume":"251","author":"Hsu","year":"1984","journal-title":"JAMA"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1111\/j.1468-1331.2010.03089.x","volume":"17","author":"Andersen","year":"2010","journal-title":"Eur J Neurol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"186","DOI":"10.12968\/denu.2016.43.2.186","volume":"43","author":"Bostock","year":"2016","journal-title":"Dent Update"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"312","DOI":"10.2165\/00003088-198916050-00003","volume":"16","author":"Friedman","year":"1989","journal-title":"Clin Pharmacokinet"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1056\/NEJM198901123200201","volume":"320","author":"Walan","year":"1989","journal-title":"N Engl J Med"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"3587","DOI":"10.1016\/j.bmc.2008.02.007","volume":"16","author":"Wang","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02605-20","volume":"65","author":"Te Velthuis","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.cbi.2006.06.002","volume":"162","author":"Ahmed","year":"2006","journal-title":"Chem Biol Interact"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3109\/08037051.2012.690615","volume":"21","author":"Toal","year":"2012","journal-title":"Blood Press"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/hr.2010.259","volume":"34","author":"Wang","year":"2011","journal-title":"Hypertens Res"},{"key":"ref53","doi-asserted-by":"publisher","volume-title":"Privileged Structures in Drug Discovery","year":"2018","DOI":"10.1002\/9781118686263.ch3"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ejogrb.2003.05.004","volume":"113","author":"Vaast","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"III10","DOI":"10.1161\/01.CIR.73.1.10","volume":"73","author":"Alousi","year":"1986","journal-title":"Circulation"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ejmech.2019.02.075","volume":"169","author":"Leoni","year":"2019","journal-title":"Eur J Med Chem"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.ejmech.2019.02.005","volume":"166","author":"de Los R\u00edos","year":"2019","journal-title":"Eur J Med Chem"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"113497","DOI":"10.1016\/j.ejmech.2021.113497","volume":"220","author":"Xu","year":"2021","journal-title":"Eur J Med Chem"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"112450","DOI":"10.1016\/j.ejmech.2020.112450","volume":"201","author":"Jian","year":"2020","journal-title":"Eur J Med Chem"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1021\/jm030432v","volume":"47","author":"Zhang","year":"2004","journal-title":"J Med Chem"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.3390\/molecules23102422","volume":"23","author":"Yang","year":"2018","journal-title":"Molecules"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"822","DOI":"10.3390\/molecules20010822","volume":"20","author":"Abdelriheem","year":"2015","journal-title":"Molecules"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/S1474-4422(15)00145-3","volume":"14","author":"Gilhus","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref64","first-page":"795","volume":"52","author":"Bugajski","year":"2001","journal-title":"J Physiol Pharmacol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/BF01998969","volume":"39","author":"Carty","year":"1993","journal-title":"Agents Actions"},{"key":"ref66","first-page":"56","volume":"38","author":"Kothekar","year":"2001","journal-title":"Indian J Biochem Biophys"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/0306-3623(88)90004-3","volume":"19","author":"Esteve","year":"1988","journal-title":"Gen Pharmacol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s000110050474","volume":"48","author":"Berg","year":"1999","journal-title":"Inflamm Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/009127007101100508","volume":"11","author":"Finch","year":"1971","journal-title":"J Clin Pharmacol New Drugs"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.prostaglandins.2006.05.019","volume":"82","author":"Capone","year":"2007","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"40224","DOI":"10.1074\/jbc.R112.386664","volume":"287","author":"Sigel","year":"2012","journal-title":"J Biol Chem"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1001\/jama.1963.03060020029016","volume":"185","author":"Dulfano","year":"1963","journal-title":"JAMA"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1046\/j.1365-2958.2001.02427.x","volume":"40","author":"Pym","year":"2001","journal-title":"Mol Microbiol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1021\/bi034772u","volume":"43","author":"Armstrong","year":"2004","journal-title":"Biochemistry"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1586\/era.10.84","volume":"10","author":"Vogiatzi","year":"2010","journal-title":"Expert Rev Anticancer Ther"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1001\/jama.280.20.1777","volume":"280","author":"Qizilbash","year":"1998","journal-title":"JAMA"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/978-1-4757-9209-6_25","volume":"394","author":"Freimuth","year":"1996","journal-title":"Adv Exp Med Biol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1001\/jama.296.24.2947","volume":"296","author":"Yang","year":"2006","journal-title":"JAMA"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1097\/00005344-199206203-00002","volume":"20","author":"Kukovetz","year":"1992","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/nrd2199","volume":"5","author":"Overington","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.1111\/j.1582-4934.2009.00660.x","volume":"13","author":"Suter","year":"2009","journal-title":"J Cell Mol Med"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1089\/jop.1994.10.431","volume":"10","author":"Vuori","year":"1994","journal-title":"J Ocul Pharmacol"},{"key":"ref83","first-page":"96","volume":"28","author":"Harvey","year":"2000","journal-title":"Drug Metab Dispos"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1517\/13543784.17.2.209","volume":"17","author":"Little","year":"2008","journal-title":"Expert Opin Investig Drugs"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1055\/s-0031-1296670","volume":"57","author":"Nada","year":"2007","journal-title":"Arzneimittelforschung"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/j.1365-2125.2003.02056.x","volume":"57","author":"Minami","year":"2004","journal-title":"Br J Clin Pharmacol"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"S92","DOI":"10.1097\/00005344-199412001-00014","volume":"24","author":"Rosenthal","year":"1994","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"4174","DOI":"10.1167\/iovs.09-4613","volume":"51","author":"Dong","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s10741-018-09765-y","volume":"24","author":"Johnson","year":"2019","journal-title":"Heart Fail Rev"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1080\/01443619964977","volume":"19","author":"Fletcher","year":"1999","journal-title":"J Obstet Gynaecol"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0006-2952(85)90121-2","volume":"34","author":"Thayer","year":"1985","journal-title":"Biochem Pharmacol"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"989","DOI":"10.2165\/00003495-200161070-00007","volume":"61","author":"Malhotra","year":"2001","journal-title":"Drugs"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1358\/mf.2005.27.3.890873","volume":"27","author":"Mielcarek","year":"2005","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/j.1460-2075.1991.tb07919.x","volume":"10","author":"Regulla","year":"1991","journal-title":"EMBO J"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1124\/dmd.105.006569","volume":"34","author":"Zhang","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"3917","DOI":"10.1016\/j.bpj.2008.12.3965","volume":"96","author":"Liu","year":"2009","journal-title":"Biophys J"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1527-3466.2002.tb00084.x","volume":"20","author":"Tanaka","year":"2002","journal-title":"Cardiovasc Drug Rev"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1128\/AAC.47.6.1805-1817.2003","volume":"47","author":"Niewerth","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/00000441-199606000-00011","volume":"311","author":"Shipley","year":"1996","journal-title":"Am J Med Sci"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/s0168-8278(02)00084-3","volume":"37","author":"Kobayashi","year":"2002","journal-title":"J Hepatol"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1038\/ki.2008.512","volume":"74","author":"L\u00f3pez","year":"2008","journal-title":"Kidney Int Suppl"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/FJC.0b013e318256cdf0","volume":"60","author":"Morgan","year":"2012","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1592\/phco.30.4.375","volume":"30","author":"Steed","year":"2010","journal-title":"Pharmacotherapy"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s40262-017-0601-x","volume":"57","author":"Roger","year":"2018","journal-title":"Clin Pharmacokinet"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2165\/00003495-198529020-00002","volume":"29","author":"Richards","year":"1985","journal-title":"Drugs"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1007\/s40265-017-0790-5","volume":"77","author":"Markham","year":"2017","journal-title":"Drugs"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1128\/AAC.47.12.3799-3805.2003","volume":"47","author":"Morlock","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"3826","DOI":"10.1128\/JVI.01968-08","volume":"83","author":"Ambrose","year":"2009","journal-title":"J Virol"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s13318-018-0497-3","volume":"43","author":"Wilby","year":"2018","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/jcc.20821","volume":"29","author":"Wittayanarakul","year":"2008","journal-title":"J Comput Chem"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"4708","DOI":"10.1200\/JCO.2007.15.9566","volume":"26","author":"Cohen","year":"2008","journal-title":"J Clin Oncol"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1124\/pr.55.3.4","volume":"55","author":"Deininger","year":"2003","journal-title":"Pharmacol Rev"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"2366s","DOI":"10.1158\/1078-0432.CCR-05-2505","volume":"12","author":"Flaherty","year":"2006","journal-title":"Clin Cancer Res"},{"key":"ref114","first-page":"4681","volume":"35","author":"Hotta","year":"2015","journal-title":"Anticancer Res"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13569-018-0101-2","volume":"8","author":"Giustini","year":"2018","journal-title":"Clin Sarcoma Res"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/S1470-2045(18)30905-7","volume":"20","author":"Konstantinopoulos","year":"2019","journal-title":"Lancet Oncol"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1016\/S1470-2045(17)30680-0","volume":"18","author":"Shaw","year":"2017","journal-title":"Lancet Oncol"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13045-016-0250-9","volume":"9","author":"Wu","year":"2016","journal-title":"J Hematol Oncol"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s10637-014-0120-7","volume":"32","author":"Gelbert","year":"2014","journal-title":"Invest New Drugs"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1200\/JCO.2009.25.8707","volume":"28","author":"Burstein","year":"2010","journal-title":"J Clin Oncol"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2147\/JBM.S70716","volume":"7","author":"Mondesir","year":"2016","journal-title":"J Blood Med"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1177\/1078155219842646","volume":"26","author":"Shore","year":"2020","journal-title":"J Oncol Pharm Pract"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"CD010696","DOI":"10.1002\/14651858.CD010696.pub2","author":"Murdin","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/nar\/30.1.412","volume":"30","author":"Chen","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"341","DOI":"10.2147\/NDT.S10464","volume":"7","author":"Lindquist","year":"2011","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1056\/NEJM198303173081103","volume":"308","author":"Allen","year":"1983","journal-title":"N Engl J Med"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1046\/j.1365-2125.2001.01471.x","volume":"52","author":"Tagawa","year":"2001","journal-title":"Br J Clin Pharmacol"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1136\/vr.115.2.45-b","volume":"115","author":"Webbon","year":"1984","journal-title":"Vet Rec"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.febslet.2006.12.028","volume":"581","author":"Sang","year":"2007","journal-title":"FEBS Lett"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"555","DOI":"10.2165\/00044011-200525090-00001","volume":"25","author":"Bell","year":"2005","journal-title":"Clin Drug Investig"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/nrd2130","volume":"5","author":"Wilhelm","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"15496","DOI":"10.1021\/ja204229m","volume":"133","author":"Oliveira","year":"2011","journal-title":"J Am Chem Soc"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ab.2006.02.020","volume":"353","author":"Ramadan","year":"2006","journal-title":"Anal Biochem"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.cbi.2010.09.018","volume":"188","author":"Dring","year":"2010","journal-title":"Chem Biol Interact"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/0014-2999(91)90363-u","volume":"197","author":"B\u00f6kesoy","year":"1991","journal-title":"Eur J Pharmacol"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1124\/jpet.110.174540","volume":"336","author":"Matsumoto","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1365-2133.1990.tb08262.x","volume":"122","author":"Roskos","year":"1990","journal-title":"Br J Dermatol"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1016\/j.amjcard.2008.02.029","volume":"101","author":"Kamanna","year":"2008","journal-title":"Am J Cardiol"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"5753","DOI":"10.1128\/AAC.00724-11","volume":"55","author":"Reeder","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1124\/jpet.110.165738","volume":"334","author":"Jackson","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/sj.clpt.6100131","volume":"82","author":"Vormfelde","year":"2007","journal-title":"Clin Pharmacol Ther"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1159\/000082325","volume":"135","author":"Wu","year":"2004","journal-title":"Int Arch Allergy Immunol"},{"key":"ref143","first-page":"131","volume":"22","author":"Allinson","year":"1990","journal-title":"Ann Ophthalmol"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.tins.2011.01.004","volume":"34","author":"Tan","year":"2011","journal-title":"Trends Neurosci"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1055\/s-0031-1296398","volume":"59","author":"Ogihara","year":"2011","journal-title":"Arzneimittelforschung"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0014-2999(86)90659-X","volume":"123","author":"Claro","year":"1986","journal-title":"Eur J Pharmacol"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"4740","DOI":"10.1021\/jm300212s","volume":"55","author":"Karlgren","year":"2012","journal-title":"J Med Chem"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1089\/dia.2006.8.677","volume":"8","author":"Broadhurst","year":"2006","journal-title":"Diabetes Technol Ther"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jnutbio.2011.11.001","volume":"23","author":"Hua","year":"2012","journal-title":"J Nutr Biochem"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1080\/13543784.2019.1618830","volume":"28","author":"Negro","year":"2019","journal-title":"Expert Opin Investig Drugs"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1111\/j.1365-2222.2005.02320.x","volume":"35","author":"Monteseirin","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1517\/14656566.2012.737780","volume":"13","author":"Jordan","year":"2012","journal-title":"Expert Opin Pharmacother"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1046\/j.0366-077X.2003.05630.x","volume":"149","author":"Dummer","year":"2003","journal-title":"Br J Dermatol"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1128\/AAC.44.10.2719-2727.2000","volume":"44","author":"B\u00e9b\u00e9ar","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1128\/AAC.43.8.1845","volume":"43","author":"Gootz","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"ref156","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01039","volume":"8","author":"Bortolin","year":"2017","journal-title":"Front Microbiol"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10915810600716570","volume":"25","author":"Andersen","year":"2006","journal-title":"Int J Toxicol"},{"key":"ref158","first-page":"114","volume":"280","author":"Merlos","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/0011-393X(95)85137-2","volume":"56","author":"Asrani","year":"1995","journal-title":"Curr Ther Res"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s00213-008-1419-x","volume":"203","author":"Weber","year":"2009","journal-title":"Psychopharmacology"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.tibs.2006.11.006","volume":"32","author":"Belenky","year":"2007","journal-title":"Trends Biochem Sci"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/355167a0","volume":"355","author":"Slater","year":"1992","journal-title":"Nature"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"e13311","DOI":"10.1111\/nmo.13311","volume":"30","author":"Krueger","year":"2018","journal-title":"Neurogastroenterol Motil"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"913","DOI":"10.2967\/jnumed.109.069088","volume":"51","author":"Wong","year":"2010","journal-title":"J Nucl Med"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1016\/j.lfs.2003.10.003","volume":"74","author":"Fitch","year":"2004","journal-title":"Life Sci"},{"key":"ref166","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.tcm.2010.03.002","volume":"20","author":"Sheets","year":"2010","journal-title":"Trends Cardiovasc Med"},{"key":"ref167","first-page":"331","volume":"8","author":"Mann","year":"1989","journal-title":"Clin Pharm"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1183\/09031936.00032806","volume":"29","author":"Naline","year":"2007","journal-title":"Eur Respir J"},{"key":"ref169","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz302","volume":"43","author":"Mahoney","year":"2020","journal-title":"Sleep"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3233\/CBM-2011-0176","volume":"9","author":"Cairns","year":"2011","journal-title":"Cancer Biomark"},{"key":"ref171","unstructured":"Shin JJ, Saadabadi A. Trazodone; 2021."},{"key":"ref172","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.jaci.2011.09.005","volume":"128","author":"Simons","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/COH.0000000000000161","volume":"10","author":"Andrews","year":"2015","journal-title":"Curr Opin HIV AIDS"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1128\/AAC.50.2.817-818.2006","volume":"50","author":"Farrell","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref175","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/hup.594","volume":"19","author":"D\u00fcndar","year":"2004","journal-title":"Hum Psychopharmacol Clin Exp"},{"key":"ref176","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.crci.2013.07.003","volume":"17","author":"Rucins","year":"2014","journal-title":"Comptes Rendus Chim"},{"key":"ref177","doi-asserted-by":"publisher","first-page":"2906","DOI":"10.1021\/jm000028l","volume":"43","author":"Peri","year":"2000","journal-title":"J Med Chem"},{"key":"ref178","doi-asserted-by":"publisher","first-page":"3743","DOI":"10.1021\/jm00075a034","volume":"36","author":"Baindur","year":"1993","journal-title":"J Med Chem"},{"key":"ref179","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1021\/ac026039z","volume":"75","author":"Fu","year":"2003","journal-title":"Anal Chem"},{"key":"ref180","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1007\/s00044-010-9477-0","volume":"20","author":"Zhou","year":"2011","journal-title":"Med Chem Res"},{"key":"ref181","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/S0014-827X(03)00159-9","volume":"58","author":"Zarghi","year":"2003","journal-title":"Farmaco"},{"key":"ref182","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.ejmech.2010.12.006","volume":"46","author":"Kumar","year":"2011","journal-title":"Eur J Med Chem"},{"key":"ref183","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/ncpendmet1066","volume":"5","author":"Mooradian","year":"2009","journal-title":"Nat Rev Endocrinol"},{"key":"ref184","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1080\/14756366.2016.1222581","volume":"31","author":"Abu Farha","year":"2016","journal-title":"J Enzyme Inhib Med Chem"},{"key":"ref185","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.ejmech.2009.10.036","volume":"45","author":"Kumar","year":"2010","journal-title":"Eur J Med Chem"},{"key":"ref186","doi-asserted-by":"publisher","first-page":"5909","DOI":"10.1016\/j.bmc.2004.08.025","volume":"12","author":"Jo","year":"2004","journal-title":"Bioorganic Med Chem"},{"key":"ref187","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.1007\/s00044-017-2026-3","volume":"26","author":"Reen","year":"2017","journal-title":"Med Chem Res"},{"key":"ref188","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1248\/bpb.b15-00586","volume":"39","author":"Salem","year":"2016","journal-title":"Biol Pharm Bull"},{"key":"ref189","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86424-7","volume":"11","author":"Khidre","year":"2021","journal-title":"Sci Rep"},{"key":"ref190","first-page":"141","volume":"9","author":"Lak","year":"2017","journal-title":"J Chem Pharm Res"},{"key":"ref191","doi-asserted-by":"publisher","DOI":"10.17877\/DE290R-641","volume":"8","author":"Prachayasittikul","year":"2009","journal-title":"EXCLI J"},{"key":"ref192","doi-asserted-by":"publisher","first-page":"12725","DOI":"10.3390\/molecules181012725","volume":"18","author":"Sun","year":"2013","journal-title":"Molecules"},{"key":"ref193","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13065-016-0196-6","volume":"10","author":"Mu","year":"2016","journal-title":"Chem Cent J"},{"key":"ref194","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3390\/polym11020371","volume":"11","author":"Wei","year":"2019","journal-title":"Polymers (Basel)"},{"key":"ref195","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.foodchem.2015.09.053","volume":"196","author":"Jia","year":"2016","journal-title":"Food Chem"},{"key":"ref196","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.carbpol.2016.09.093","volume":"157","author":"Tan","year":"2017","journal-title":"Carbohydr Polym"},{"key":"ref197","doi-asserted-by":"publisher","first-page":"103673","DOI":"10.1016\/j.bioorg.2020.103673","volume":"97","author":"Elshemy","year":"2020","journal-title":"Bioorg Chem"},{"key":"ref198","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1021\/ml300419r","volume":"4","author":"Xue","year":"2013","journal-title":"ACS Med Chem Lett"},{"key":"ref199","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1002\/ardp.201300183","volume":"346","author":"Salem","year":"2013","journal-title":"Arch Pharm"},{"key":"ref200","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1134\/S1070363217100279","volume":"87","author":"El-Sayed","year":"2017","journal-title":"Russ J Gen Chem"},{"key":"ref201","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1021\/acs.jmedchem.8b01213","volume":"62","author":"Asquith","year":"2019","journal-title":"J Med Chem"},{"key":"ref202","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.1021\/jm501759m","volume":"58","author":"Kovackova","year":"2015","journal-title":"J Med Chem"},{"key":"ref203","doi-asserted-by":"publisher","first-page":"6178","DOI":"10.1021\/acs.jmedchem.8b00613","volume":"61","author":"Pu","year":"2018","journal-title":"J Med Chem"},{"key":"ref204","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1039\/C5MD00229J","volume":"6","author":"Li","year":"2015","journal-title":"Medchemcomm"},{"key":"ref205","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.ejmech.2018.11.065","volume":"163","author":"Wouters","year":"2019","journal-title":"Eur J Med Chem"},{"key":"ref206","doi-asserted-by":"publisher","first-page":"115188","DOI":"10.1016\/j.bmc.2019.115188","volume":"28","author":"Martinez-Gualda","year":"2020","journal-title":"Bioorg Med Chem"},{"key":"ref207","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1002\/iub.1334","volume":"66","author":"Xu","year":"2014","journal-title":"IUBMB Life"},{"key":"ref208","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/nrd1523","volume":"3","author":"Lombardino","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"ref209","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.2165\/00003495-200969110-00008","volume":"69","author":"Croom","year":"2009","journal-title":"Drugs"},{"key":"ref210","doi-asserted-by":"publisher","first-page":"112863","DOI":"10.1016\/j.ejmech.2020.112863","volume":"209","author":"Khan","year":"2021","journal-title":"Eur J Med Chem"},{"key":"ref211","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ejmech.2017.09.070","volume":"141","author":"Khan","year":"2017","journal-title":"Eur J Med Chem"},{"key":"ref212","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s12039-010-0070-3","volume":"122","author":"Thirumurugan","year":"2010","journal-title":"J Chem Sci"},{"key":"ref213","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1016\/j.bmcl.2013.02.059","volume":"23","author":"Liu","year":"2013","journal-title":"Bioorganic Med Chem Lett"},{"key":"ref214","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.3390\/molecules26051272","volume":"26","author":"Yaqoob","year":"2021","journal-title":"Molecules"},{"key":"ref215","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/978-1-4939-2895-8_5","author":"Kuo","year":"2015","journal-title":"Glucocorticoid Signal"},{"key":"ref216","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1016\/j.ajpath.2016.01.014","volume":"186","author":"Terao","year":"2016","journal-title":"Am J Pathol"},{"key":"ref217","doi-asserted-by":"publisher","first-page":"103056","DOI":"10.1016\/j.bioorg.2019.103056","volume":"90","author":"Praveenkumar","year":"2019","journal-title":"Bioorg Chem"},{"key":"ref218","doi-asserted-by":"publisher","first-page":"17268","DOI":"10.1039\/C8NJ02495B","volume":"42","author":"Adib","year":"2018","journal-title":"New J Chem"},{"key":"ref219","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/mds.22432","volume":"24","author":"Hart","year":"2009","journal-title":"Mov Disord"},{"key":"ref220","doi-asserted-by":"publisher","first-page":"102302","DOI":"10.1016\/j.isci.2021.102302","volume":"24","author":"Li","year":"2021","journal-title":"iScience"},{"key":"ref221","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/imm.12922","volume":"154","author":"Stephenson","year":"2018","journal-title":"Immunology"},{"key":"ref222","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41536-020-00107-x","volume":"5","author":"Norat","year":"2020","journal-title":"NPJ Regen Med"},{"key":"ref223","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3390\/ph11020044","volume":"11","author":"Dur\u00e3es","year":"2018","journal-title":"Pharmaceuticals"},{"key":"ref224","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000147","author":"Birks","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"ref225","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2174\/1570159X17666190927113021","volume":"18","author":"Carlson","year":"2020","journal-title":"Curr Neuropharmacol"},{"key":"ref226","doi-asserted-by":"publisher","DOI":"10.1590\/s2175-97902019000418325","volume":"56","author":"Ul Mohsin","year":"2020","journal-title":"Braz J Pharm Sci"},{"key":"ref227","doi-asserted-by":"publisher","first-page":"355","DOI":"10.2174\/0929867003375281","volume":"7","author":"Bai","year":"2000","journal-title":"Curr Med Chem"},{"key":"ref228","doi-asserted-by":"publisher","first-page":"7166","DOI":"10.2174\/0929867325666180904125400","volume":"26","author":"Chiacchio","year":"2020","journal-title":"Curr Med Chem"},{"key":"ref229","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1007\/s00706-007-0656-8","volume":"138","author":"Abdel-Latif","year":"2007","journal-title":"Monatshefte f\u00fcr Chemie"},{"key":"ref230","doi-asserted-by":"publisher","volume-title":"Taurine 6","year":"2006","DOI":"10.1007\/978-0-387-33504-9_56"},{"key":"ref231","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/cbf.1340","volume":"25","author":"Klimaviciusa","year":"2007","journal-title":"Cell Biochem Funct"},{"key":"ref232","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S1567-7249(03)00060-6","volume":"3","author":"Fernandes","year":"2003","journal-title":"Mitochondrion"},{"key":"ref233","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/j.1742-7843.2008.00221.x","volume":"103","author":"Pupure","year":"2008","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref234","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s13760-015-0520-2","volume":"116","author":"Lan","year":"2016","journal-title":"Acta Neurol Belg"},{"key":"ref235","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1021\/acschemneuro.6b00432","volume":"8","author":"Marcinkowska","year":"2017","journal-title":"ACS Chem Neurosci"},{"key":"ref236","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1021\/np200814j","volume":"75","author":"Francisco","year":"2012","journal-title":"J Nat Prod"},{"key":"ref237","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1021\/np900644x","volume":"73","author":"Serrano","year":"2010","journal-title":"J Nat Prod"},{"key":"ref238","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.ejmech.2019.02.054","volume":"168","author":"Ling","year":"2019","journal-title":"Eur J Med Chem"},{"key":"ref239","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.ejmech.2019.01.070","volume":"166","author":"Dai","year":"2019","journal-title":"Eur J Med Chem"},{"key":"ref240","doi-asserted-by":"publisher","first-page":"102914","DOI":"10.1016\/j.arabjc.2020.11.020","volume":"14","author":"Alqahtani","year":"2021","journal-title":"Arab J Chem"},{"key":"ref241","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1021\/acs.jmedchem.0c01516","volume":"64","author":"Brown","year":"2021","journal-title":"J Med Chem"},{"key":"ref242","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1016\/j.arabjc.2015.11.008","volume":"12","author":"Sailaja","year":"2019","journal-title":"Arab J Chem"},{"key":"ref243","doi-asserted-by":"publisher","DOI":"10.2174\/1871520616666161206143251","volume":"17","author":"Viradiya","year":"2017","journal-title":"Anticancer Agents Med Chem"},{"key":"ref244","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jhet.3881","author":"Mahmoud","year":"2019","journal-title":"J Heterocycl Chem"},{"key":"ref245","doi-asserted-by":"publisher","first-page":"459","DOI":"10.24820\/ark.5550190.p011.056","volume":"2019","author":"Hamza","year":"2019","journal-title":"Arkivoc"},{"key":"ref246","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.bioorg.2014.09.003","volume":"57","author":"Davari","year":"2014","journal-title":"Bioorg Chem"},{"key":"ref247","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.1016\/j.bmcl.2010.05.080","volume":"20","author":"Liu","year":"2010","journal-title":"Bioorganic Med Chem Lett"},{"key":"ref248","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1007\/s11164-011-0413-9","volume":"38","author":"Bassyouni","year":"2012","journal-title":"Res Chem Intermed"},{"key":"ref249","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.bmcl.2016.01.014","volume":"26","author":"Abdelazem","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"ref250","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s10876-010-0298-6","volume":"21","author":"S\u00fcss-Fink","year":"2010","journal-title":"J Clust Sci"},{"key":"ref251","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jorganchem.2012.10.016","volume":"730","author":"Khan","year":"2013","journal-title":"J Organomet Chem"},{"key":"ref252","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.ejmech.2014.12.010","volume":"90","author":"Eldehna","year":"2015","journal-title":"Eur J Med Chem"},{"key":"ref253","doi-asserted-by":"publisher","first-page":"5893","DOI":"10.1016\/j.bmcl.2013.08.089","volume":"23","author":"Chavva","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"ref254","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1016\/j.bmc.2012.02.015","volume":"20","author":"Abdel-Megeed","year":"2012","journal-title":"Bioorg Med Chem"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=74879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=74879","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T16:28:24Z","timestamp":1673454504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-expanding-role-of-pyridine-and-dihydropyridine-scaffolds-in-drug-d-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":254,"URL":"https:\/\/doi.org\/10.2147\/dddt.s329547","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}