{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:24:34Z","timestamp":1791998674167,"version":"4.4.0"},"reference-count":93,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s337925","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T09:40:32Z","timestamp":1639042832000},"page":"4939-4959","source":"Crossref","is-referenced-by-count":18,"title":["New Progress in Improving the Delivery Methods of Bisphosphonates in the Treatment of Bone Tumors"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Yu","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-8618","authenticated-orcid":true,"given":"Su","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1002\/jbmr.3618","volume":"33","author":"Fornetti","year":"2018","journal-title":"J Bone Miner Res"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0578-1","volume":"36","author":"Gdowski","year":"2017","journal-title":"J Exper Clin Cancer Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/nrc867","volume":"2","author":"Mundy","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"ref5","first-page":"695","volume":"30","author":"Coleman","year":"2016","journal-title":"Oncology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1634\/theoncologist.9-90004-14","volume":"9","author":"Coleman","year":"2004","journal-title":"Oncologist"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.2174\/187152012799014995","volume":"12","author":"Saad","year":"2012","journal-title":"Anticancer Agents Med Chem"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.ejca.2012.02.050","volume":"48","author":"Keizman","year":"2012","journal-title":"Eur J Cancer"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1007\/s00520-018-4060-1","volume":"26","author":"Menshawy","year":"2018","journal-title":"Support Care Cancer"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"172773","DOI":"10.1016\/j.ejphar.2019.172773","volume":"866","author":"Ku\u017anik","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/leu.2011.282","volume":"26","author":"Modi","year":"2012","journal-title":"Leukemia"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.bone.2011.04.022","volume":"49","author":"Russell","year":"2011","journal-title":"Bone"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1016\/S1470-2045(20)30559-3","volume":"22","author":"Terpos","year":"2021","journal-title":"Lancet Oncol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.metabol.2017.11.012","volume":"80","author":"Terpos","year":"2018","journal-title":"Metabolism"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.coph.2018.03.010","volume":"40","author":"Young","year":"2018","journal-title":"Curr Opin Pharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1093\/annonc\/mdn796","volume":"20","author":"Terpos","year":"2009","journal-title":"Ann Oncol"},{"key":"ref17","first-page":"377","volume":"7","author":"Rosen","year":"2001","journal-title":"Cancer J"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"5571","DOI":"10.1002\/jcb.26728","volume":"119","author":"Kim","year":"2018","journal-title":"J Cell Biochem"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"215","DOI":"10.4103\/aja.aja_12_18","volume":"20","author":"Dorff","year":"2018","journal-title":"Asian J Androl"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1016\/S0960-894X(03)00648-6","volume":"13","author":"Wang","year":"2003","journal-title":"Bioorg Med Chem Lett"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.addr.2004.12.011","volume":"57","author":"Wang","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/1061186X.2014.950668","volume":"23","author":"Singh","year":"2014","journal-title":"J Drug Target"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1016\/j.biomaterials.2013.11.077","volume":"35","author":"Cole","year":"2014","journal-title":"Biomaterials"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.addr.2017.07.003","volume":"114","author":"Hodgins","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1039\/C5BM00355E","volume":"4","author":"Kootala","year":"2016","journal-title":"Biomater Sci"},{"key":"ref26","first-page":"874","volume":"16","author":"Gradishar","year":"2018","journal-title":"Breast Cancer"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.addr.2015.10.005","volume":"99","author":"Cole","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1002\/jbm.a.36968","volume":"108","author":"Otaka","year":"2020","journal-title":"J Biomed Mater Res A"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"7311","DOI":"10.1021\/acsami.8b16588","volume":"11","author":"Li","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1021\/acsnano.9b04571","volume":"14","author":"Vanderburgh","year":"2020","journal-title":"ACS Nano"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1089\/ten.2006.0394","volume":"13","author":"Kretlow","year":"2007","journal-title":"Tissue Eng"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.22203\/eCM.v033a05","volume":"33","author":"Vega","year":"2017","journal-title":"Eur Cell Mater"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"10287","DOI":"10.1073\/pnas.1401337111","volume":"111","author":"Swami","year":"2014","journal-title":"Proc Nat Acad Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1208\/s12249-016-0691-z","volume":"18","author":"Raichur","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1039\/D0TB00046A","volume":"8","author":"Chen","year":"2020","journal-title":"J Mater Chem B"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1021\/mp200083n","volume":"8","author":"Miller","year":"2011","journal-title":"Mol Pharm"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/srep36707","volume":"6","author":"Nguyen","year":"2016","journal-title":"Sci Rep"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"629928","DOI":"10.3389\/fbioe.2021.629928","volume":"9","author":"Xu","year":"2021","journal-title":"Front Bioeng Biotech"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.2217\/nnm-2016-0151","volume":"11","author":"Mekhail","year":"2016","journal-title":"Nanomedicine"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"9912","DOI":"10.1021\/jacs.8b04457","volume":"140","author":"Chen","year":"2018","journal-title":"J Am Chem Soc"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1606134","DOI":"10.1002\/adma.201606134","volume":"29","author":"Wu","year":"2017","journal-title":"Adv Mater"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"110977","DOI":"10.1016\/j.jinorgbio.2019.110977","volume":"205","author":"Muguruza","year":"2020","journal-title":"J Inorg Biochem"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.biomaterials.2015.12.018","volume":"82","author":"Au","year":"2016","journal-title":"Biomaterials"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1021\/acs.nanolett.9b02916","volume":"20","author":"Pang","year":"2019","journal-title":"Nano Lett"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1605754","DOI":"10.1002\/adma.201605754","volume":"29","author":"Li","year":"2017","journal-title":"Adv Mater"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"9237","DOI":"10.1021\/acs.langmuir.6b02228","volume":"32","author":"Sun","year":"2016","journal-title":"Langmuir"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4061\/2010\/747852","volume":"2010","author":"Lalatonne","year":"2010","journal-title":"J Osteoporos"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"109967","DOI":"10.1016\/j.msec.2019.109967","volume":"104","author":"Dlamini","year":"2019","journal-title":"Mater Sci Eng C"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.biomaterials.2005.06.012","volume":"27","author":"Wright","year":"2006","journal-title":"Biomaterials"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1021\/bm070121s","volume":"8","author":"Murphy","year":"2007","journal-title":"Biomacromolecules"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1080\/21691401.2017.1416390","volume":"46","author":"Dong","year":"2018","journal-title":"Artif Cells, Nanomed Biotechnol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1021\/acs.molpharmaceut.8b01343","volume":"16","author":"Liu","year":"2019","journal-title":"Mol Pharm"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1007\/s10637-015-0253-3","volume":"33","author":"Schott","year":"2015","journal-title":"Invest New Drugs"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-72552-z","volume":"10","author":"Yuan","year":"2020","journal-title":"Sci Rep"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"255101","DOI":"10.1088\/1361-6528\/ab055f","volume":"30","author":"Zhao","year":"2019","journal-title":"Nanotechnology"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"833","DOI":"10.2217\/nnm-2020-0024","volume":"15","author":"Bai","year":"2020","journal-title":"Nanomedicine"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/1556-276X-8-102","volume":"8","author":"Akbarzadeh","year":"2013","journal-title":"Nanoscale Res Lett"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jconrel.2013.03.036","volume":"169","author":"Ta","year":"2013","journal-title":"J Control Release"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.semcancer.2019.12.001","volume":"68","author":"La-beck","year":"2019","journal-title":"Semin Cancer Biol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.nano.2017.03.005","volume":"13","author":"Dos Santos Ferreira","year":"2017","journal-title":"Nanomedicine"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10837450.2015.1048593","volume":"21","author":"Song","year":"2016","journal-title":"Pharm Dev Technol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1016\/j.ijbiomac.2020.08.068","volume":"164","author":"Wu","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.ijpharm.2018.11.023","volume":"554","author":"Dolci","year":"2019","journal-title":"Int J Pharm"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"3629","DOI":"10.1080\/10717544.2016.1214989","volume":"23","author":"Chang","year":"2016","journal-title":"Drug Deliv"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.nano.2011.03.004","volume":"7","author":"Marra","year":"2011","journal-title":"Nanomedicine"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"4148","DOI":"10.1016\/j.bmcl.2009.05.117","volume":"19","author":"Anada","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s11095-008-9759-0","volume":"26","author":"Shi","year":"2009","journal-title":"Pharm Res"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ijpharm.2010.07.045","volume":"398","author":"Han","year":"2010","journal-title":"Int J Pharm"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.jconrel.2012.05.003","volume":"161","author":"Hern\u00e1n P\u00e9rez De La Ossa","year":"2012","journal-title":"J Control Release"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0030-5898(05)70117-6","volume":"30","author":"Bostrom","year":"1999","journal-title":"Orthop Clin North Am"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1007\/s10856-014-5289-y","volume":"25","author":"Wu","year":"2014","journal-title":"J Mater Sci Mater Med"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0028-x","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jconrel.2010.06.016","volume":"147","author":"Kim","year":"2010","journal-title":"J Control Release"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"065003","DOI":"10.1088\/1748-6041\/11\/6\/065003","volume":"11","author":"Cattalini","year":"2016","journal-title":"Biomed Mater"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"5544","DOI":"10.1039\/C5TB00893J","volume":"3","author":"Bell","year":"2015","journal-title":"J Mater Chem B"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"115492","DOI":"10.1016\/j.bone.2020.115492","volume":"138","author":"Xing","year":"2020","journal-title":"Bone"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.bonr.2018.06.007","volume":"9","author":"Farrell","year":"2018","journal-title":"Bone Rep"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3892\/ijo_00000705","volume":"37","author":"Holmberg","year":"2010","journal-title":"Int J Oncol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"8781","DOI":"10.1021\/ja902857b","volume":"131","author":"Varghese","year":"2009","journal-title":"J Am Chem Soc"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"6455","DOI":"10.1016\/j.bmcl.2013.09.043","volume":"23","author":"Agyin","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3390\/pharmaceutics10030154","volume":"10","author":"Wang","year":"2018","journal-title":"Pharmaceutics"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1021\/acs.bioconjchem.9b00210","volume":"30","author":"David","year":"2019","journal-title":"Bioconjug Chem"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"6647","DOI":"10.1021\/jm200521a","volume":"54","author":"Webster","year":"2011","journal-title":"J Med Chem"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05553-0","volume":"7","author":"Tanaka","year":"2017","journal-title":"Sci Rep"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"18387","DOI":"10.1039\/C8NR03899F","volume":"10","author":"Zhu","year":"2018","journal-title":"Nanoscale"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"7502","DOI":"10.1021\/jm300493m","volume":"55","author":"Hochd\u00f6rffer","year":"2012","journal-title":"J Med Chem"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1002\/cmdc.201600465","volume":"11","author":"Matsumoto","year":"2016","journal-title":"ChemMedChem"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1002\/cmdc.201800764","volume":"14","author":"Mizuta","year":"2019","journal-title":"ChemMedChem"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1080\/03639045.2019.1572184","volume":"45","author":"Morsi","year":"2019","journal-title":"Drug Dev Ind Pharm"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"109937","DOI":"10.1016\/j.msec.2019.109937","volume":"104","author":"Thavornyutikarn","year":"2019","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.actbio.2018.07.028","volume":"77","author":"Li","year":"2018","journal-title":"Acta Biomater"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.msec.2017.08.043","volume":"82","author":"Lu","year":"2018","journal-title":"Mat Sci Eng C"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1089\/ten.tea.2016.0001","volume":"22","author":"Farbod","year":"2016","journal-title":"Tissue Eng Part A"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=76638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=76638","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T09:40:52Z","timestamp":1639042852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/new-progress-in-improving-the-delivery-methods-of-bisphosphonates-in-t-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":93,"URL":"https:\/\/doi.org\/10.2147\/dddt.s337925","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]}}}