{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:36:33Z","timestamp":1790807793343,"version":"4.1.0"},"reference-count":64,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s343978","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T05:30:05Z","timestamp":1650605405000},"page":"1159-1170","source":"Crossref","is-referenced-by-count":66,"title":["Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3\/NF-\u03baB Pathwayt"],"prefix":"10.2147","volume":"Volume 16","author":[{"given":"Muhammad","family":"Riaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-7655","authenticated-orcid":true,"given":"Lina Tariq","family":"Al Kury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noreen","family":"Atzaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Alattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Alshaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-2179","authenticated-orcid":true,"given":"Fawad Ali","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shupeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1056\/NEJMoa050373","volume":"353","author":"Becker","year":"2005","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s00296-013-2690-7","volume":"34","author":"Chatzipavlou","year":"2014","journal-title":"Rheumatol Int"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/s41584-020-0441-1","volume":"16","author":"Dehlin","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"ref4","first-page":"71","volume":"4","author":"Ashiq","year":"2021","journal-title":"JPMA"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/acr.23926","volume":"72","author":"Chiou","year":"2020","journal-title":"Arthritis Care Res"},{"key":"ref6","first-page":"3167","volume":"12","author":"Li","year":"2020","journal-title":"Am J Transl Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1007\/s11926-013-0400-9","volume":"16","author":"Martillo","year":"2014","journal-title":"Curr Rheumatol Rep"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/MD.0000000000004177","volume":"95","author":"Cho","year":"2016","journal-title":"Medicine"},{"key":"ref9","first-page":"56","volume":"4","author":"Shah","year":"2016","journal-title":"SciELO Bras"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2337\/dc11-1346","volume":"35","author":"Zoppini","year":"2012","journal-title":"Diabetes Care"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.metabol.2003.11.017","volume":"53","author":"Ogura","year":"2004","journal-title":"Metabolism"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/jch.12627","volume":"18","author":"Yokokawa","year":"2016","journal-title":"J Clin Hypertens"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1177\/1759720X16646703","volume":"8","author":"Sattui","year":"2016","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/fmed.2018.00160","volume":"5","author":"Benn","year":"2018","journal-title":"Front med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1093\/rheumatology\/keh640","volume":"44","author":"Dalbeth","year":"2005","journal-title":"Rheumatology"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.1046\/j.1432-1033.2002.03245.x","volume":"269","author":"Filipe","year":"2002","journal-title":"Eur J Biochem"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/0014-5793(89)81166-4","volume":"244","author":"Aruoma","year":"1989","journal-title":"FEBS Lett"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.0105-2896.2009.00860.x","volume":"233","author":"Martinon","year":"2010","journal-title":"Immunol Rev"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar2952","volume":"12","author":"Busso","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nri3452","volume":"13","author":"Latz","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.abb.2019.01.031","volume":"670","author":"Szekanecz","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"ref22","first-page":"e45","volume":"2020","author":"Wang","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1039\/C6FO01561A","volume":"8","author":"Chen","year":"2017","journal-title":"Food Funct"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.freeradbiomed.2020.03.007","volume":"152","author":"Deng","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e270","DOI":"10.1016\/S2665-9913(20)30065-5","volume":"2","author":"Kl\u00fcck","year":"2020","journal-title":"Lancet Rheumatol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.cbi.2008.07.003","volume":"176","author":"Liu","year":"2008","journal-title":"Chem Biol Interact"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/JLB.3HI0518-193R","volume":"105","author":"Liu","year":"2019","journal-title":"J Leukoc Biol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jtemb.2019.08.012","volume":"56","author":"Kiyani","year":"2019","journal-title":"J Trace Elem Med Biol"},{"key":"ref29","first-page":"217","volume":"2022","author":"Kiyani","year":"2000","journal-title":"Biol Trace Elem Res"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3389\/fnins.2020.00659","volume":"14","author":"Malik","year":"2020","journal-title":"Front Neurosci"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.3390\/molecules25112540","volume":"25","author":"Al Kury","year":"2020","journal-title":"Molecules"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"663","DOI":"10.3389\/fphar.2019.00663","volume":"10","author":"Shah","year":"2019","journal-title":"Front Pharmacol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1002\/ptr.6103","volume":"32","author":"Sharifi\u2010Rad","year":"2018","journal-title":"Phytother Res"},{"key":"ref34","volume-title":"Dietary Interventions in Gastrointestinal Diseases","year":"2019"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jep.2009.12.035","volume":"128","author":"Wang","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12906-018-2415-2","volume":"19","author":"Oh","year":"2019","journal-title":"BMC Complement Altern Med"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1080\/08923973.2020.1746802","volume":"42","author":"Ullah","year":"2020","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1021\/acschemneuro.0c00659","volume":"12","author":"Imran","year":"2021","journal-title":"ACS Chem Neurosci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"816","DOI":"10.3390\/biom10060816","volume":"10","author":"Mohsin Alvi","year":"2020","journal-title":"Biomolecules"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3389\/fnmol.2020.00033","volume":"13","author":"Ali","year":"2020","journal-title":"Front Mol Neurosci"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3390\/biom10010108","volume":"10","author":"Imran","year":"2020","journal-title":"Biomolecules"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3390\/biom10030443","volume":"10","author":"Iqbal","year":"2020","journal-title":"Biomolecules"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.2147\/JIR.S284471","volume":"13","author":"Zulfiqar","year":"2020","journal-title":"J Inflamm Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.3389\/fphar.2020.00034","volume":"11","author":"Rahman","year":"2020","journal-title":"Front Pharmacol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1002\/art.39254","volume":"67","author":"Neogi","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00210-011-0715-x","volume":"385","author":"Guimar\u00e3es","year":"2012","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1089\/jmf.2012.0102","volume":"15","author":"Silva","year":"2012","journal-title":"J Med Food"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.procbio.2019.03.014","volume":"83","author":"Rezaeinasab","year":"2019","journal-title":"Process Biochem"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.ejphar.2012.11.040","volume":"699","author":"da Silva Lima","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"ref50","first-page":"56","volume":"4","author":"Kiyani","year":"2021","journal-title":"Biol Trace Elem Res"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1172\/JCI115142","volume":"87","author":"Di Giovine","year":"1991","journal-title":"J Clin Invest"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1002\/art.20317","volume":"50","author":"Yagnik","year":"2004","journal-title":"Arthritis Rheum"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"39","DOI":"10.2147\/JIR.S11330","volume":"4","author":"Kingsbury","year":"2011","journal-title":"J Inflamm Res"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nm.3806","volume":"21","author":"Coll","year":"2015","journal-title":"Nat Med"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nm.3804","volume":"21","author":"Youm","year":"2015","journal-title":"Nat Med"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.1002\/art.24959","volume":"60","author":"Guma","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature04516","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"ref58","first-page":"1","volume":"11","author":"Gout","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.semarthrit.2020.04.010","volume":"50","author":"Pillinger","year":"2020","journal-title":"Sem Arthritis Rheumatism"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.3390\/molecules26041071","volume":"26","author":"Choi","year":"2021","journal-title":"Molecules"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0002-9343(84)90743-5","volume":"76","author":"Hande","year":"1984","journal-title":"Am J Med"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/6943860","volume":"2020","author":"Han","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Ahmadvand H, Tavafi M, Asadollahi V, et al. Protective effect of carvacrol on renal functional and histopathological changes in gentamicin-induced-nephrotoxicity in rats; 2016.","DOI":"10.17795\/zjrms-6446"},{"key":"ref64","first-page":"125","volume":"67","author":"Hilmi","year":"2012","journal-title":"Med J Malaysia"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=80194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=80194","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T05:30:20Z","timestamp":1650605420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/carvacrol-alleviates-hyperuricemia-induced-oxidative-stress-and-inflam-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":64,"URL":"https:\/\/doi.org\/10.2147\/dddt.s343978","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}