{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:02:17Z","timestamp":1747206137974,"version":"3.40.5"},"reference-count":54,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s350387","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T09:30:42Z","timestamp":1649151042000},"page":"1011-1024","source":"Crossref","is-referenced-by-count":3,"title":["Targets Exploration of Hydroxychloroquine for Pigmentation and Cell Protection Effect in Melanocytes: The Clue for Vitiligo Treatment"],"prefix":"10.2147","volume":"Volume 16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-863X","authenticated-orcid":true,"given":"Bo","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yebei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzu","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2022,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/S0140-6736(14)60763-7","volume":"386","author":"Ezzedine","year":"2015","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1159\/000506103","volume":"236","author":"Bergqvist","year":"2020","journal-title":"Dermatology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.jaad.2010.11.061","volume":"65","author":"Alikhan","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"15011","DOI":"10.1038\/nrdp.2015.11","volume":"1","author":"Picardo","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.coi.2016.09.008","volume":"43","author":"Strassner","year":"2016","journal-title":"Curr Opin Immunol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/exd.12372","volume":"23","author":"Laddha","year":"2014","journal-title":"Exp Dermatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/pcmr.13006","volume":"35","author":"Xie","year":"2022","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.humimm.2014.09.003","volume":"75","author":"Al-Shobaili","year":"2014","journal-title":"Hum Immunol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jdermsci.2015.09.003","volume":"81","author":"Xie","year":"2016","journal-title":"J Dermatol Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1111\/1756-185X.12442","volume":"18","author":"Joo","year":"2015","journal-title":"Int J Rheum Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1136\/annrheumdis-2019-215089","volume":"78","author":"Fanouriakis","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1136\/annrheumdis-2019-216655","volume":"79","author":"Smolen","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1136\/annrheumdis-2019-216114","volume":"79","author":"Ramos-Casals","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e150","DOI":"10.1111\/ajd.13168","volume":"61","author":"Chew","year":"2020","journal-title":"Australas J Dermatol"},{"key":"ref15","first-page":"1470","volume":"18","author":"Niebel","year":"2020","journal-title":"J Dtsch Dermatol Ges"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/0190-9622(95)91842-6","volume":"33","author":"Walsh","year":"1995","journal-title":"J Am Acad Dermatol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ijwd.2020.06.009","volume":"6","author":"Kwak","year":"2020","journal-title":"Int J Womens Dermatol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jaip.2013.06.003","volume":"1","author":"Khan","year":"2013","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.3892\/mmr.2016.5354","volume":"14","author":"Li","year":"2016","journal-title":"Mol Med Rep"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"7518374","DOI":"10.1155\/2019\/7518374","author":"Ma","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11655-019-3064-0","volume":"26","author":"Luo","year":"2020","journal-title":"Chin J Integr Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"112055","DOI":"10.1016\/j.jep.2019.112055","volume":"242","author":"Ding","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1080\/14786419.2018.1440222","volume":"33","author":"Zhang","year":"2019","journal-title":"Nat Prod Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s13059-019-1758-4","volume":"20","author":"Otasek","year":"2019","journal-title":"Genome Biol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1177\/0961203320952541","volume":"29","author":"Xie","year":"2020","journal-title":"Lupus"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.5","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr Protoc Bioinform"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"105099","DOI":"10.1016\/j.jbspin.2020.105099","volume":"88","author":"Xie","year":"2021","journal-title":"Joint Bone Spine"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1471-2105-11-91","volume":"11","author":"Martin","year":"2010","journal-title":"BMC Bioinform"},{"key":"ref29","first-page":"831","volume":"12","author":"Rizvi","year":"2013","journal-title":"EXCLI J"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"7617839","DOI":"10.1155\/2021\/7617839","volume":"2021","author":"Tian","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1038\/s41591-018-0028-4","volume":"24","author":"Beekman","year":"2018","journal-title":"Nat Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1093\/bioinformatics\/bts356","volume":"28","author":"Wang","year":"2012","journal-title":"Bioinformatics"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"188","DOI":"10.12688\/f1000research.2-188.v1","volume":"2","author":"Florea","year":"2013","journal-title":"F1000Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nbt.3122","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat Biotechnol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"153274","DOI":"10.1016\/j.phymed.2020.153274","volume":"77","author":"Li","year":"2020","journal-title":"Phytomedicine"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.csbj.2021.01.033","volume":"19","author":"Li","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"4835","DOI":"10.3892\/mmr.2016.5112","volume":"13","author":"Raju","year":"2016","journal-title":"Mol Med Rep"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1038\/jid.2012.164","volume":"132","author":"Bigot","year":"2012","journal-title":"J Invest Dermatol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/bjd.12439","volume":"169","author":"Osborne","year":"2013","journal-title":"Br J Dermatol"},{"key":"ref42","first-page":"1429","volume":"36","author":"Rossberg","year":"2016","journal-title":"Anticancer Res"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1038\/s41436-020-0867-5","volume":"22","author":"Pennamen","year":"2020","journal-title":"Genet Med"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1111\/pcmr.12995","volume":"34","author":"Zhong","year":"2021","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.addr.2020.02.002","volume":"153","author":"Rachmin","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"8864100","DOI":"10.1155\/2020\/8864100","volume":"2020","author":"Fu","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1469-185X.2008.00042.x","volume":"83","author":"Zhang","year":"2008","journal-title":"Biol Rev Camb Philos Soc"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.1093\/nar\/gkz055","volume":"47","author":"Wienholz","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"13771","DOI":"10.1074\/jbc.M116.724658","volume":"291","author":"Higa","year":"2016","journal-title":"J Biol Chem"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"6143","DOI":"10.3390\/ijms20246143","volume":"20","author":"Jackson","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1016\/S0024-3205(03)00083-3","volume":"72","author":"Wessler","year":"2003","journal-title":"Life Sci"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/phpp.12653","volume":"37","author":"Said","year":"2021","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1034\/j.1600-0749.13.s8.9.x","volume":"13","author":"Taieb","year":"2000","journal-title":"Pigment Cell Res"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/BF02505037","volume":"288","author":"Schallreuter","year":"1996","journal-title":"Arch Dermatol Res"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=79668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=79668","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T09:30:45Z","timestamp":1649151045000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/targets-exploration-of-hydroxychloroquine-for-pigmentation-and-cell-pr-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":54,"URL":"https:\/\/doi.org\/10.2147\/dddt.s350387","relation":{},"ISSN":["1177-8881"],"issn-type":[{"type":"electronic","value":"1177-8881"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}