{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:08:20Z","timestamp":1792886900021,"version":"4.5.0"},"reference-count":43,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s356307","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T13:10:08Z","timestamp":1656681008000},"page":"2119-2132","source":"Crossref","is-referenced-by-count":101,"title":["Palmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-\u03baB\/NLRP3 and Nrf2 Pathways"],"prefix":"10.2147","volume":"Volume 16","author":[{"given":"Juan-Juan","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Dong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao-Xiang","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Xia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Hui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Ren","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Feng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.75.suppl_5.s9","volume":"75 Suppl 5:S9-S12","author":"Weaver","year":"2008","journal-title":"Cleve Clin J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12974-017-0849-y","volume":"14","author":"Liu","year":"2017","journal-title":"J Neuroinflammation"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nrrheum.2014.32","volume":"10","author":"Rees","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","volume":"13","author":"So","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41584-018-0004-x","volume":"14","author":"Major","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.molimm.2018.09.010","volume":"103","author":"Liu","year":"2018","journal-title":"Mol Immunol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.freeradbiomed","volume":"51","author":"Tsai","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1186\/s13075-015-0844-6","volume":"17","author":"Ka","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1089\/ars.2015.6615","volume":"26","author":"Liu","year":"2017","journal-title":"Antioxid Redox Signal"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"41","DOI":"10.4103\/0973-1296.176023","volume":"12","author":"Sun","year":"2016","journal-title":"Pharmacogn Mag"},{"key":"ref12","unstructured":"Commission, C. P. J. P. s. M. P. H. Pharmacopoeia of the People\u2019s Republic of China."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e0168944","DOI":"10.1371\/journal.pone.0168944","volume":"12","author":"Zhou","year":"2017","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.ejmech.2013.12.036","volume":"103","author":"Pathan","year":"2015","journal-title":"Eur J Med Chem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.intimp.2017.02.025","volume":"46","author":"Chen","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.intimp.2017.02.004","volume":"45","author":"Yan","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"6660193","DOI":"10.1155\/2021\/6660193","author":"Tang","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.bjoms.2020.01.031","volume":"58","author":"He","year":"2020","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.intimp.2016.02.029","volume":"34","author":"Zhou","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2174\/1381612826666200728144605","volume":"27","author":"Orhan","year":"2021","journal-title":"Curr Pharm Des"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"6718","DOI":"10.1002\/jcb.27969","volume":"120","author":"Li","year":"2019","journal-title":"J Cell Biochem"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1002\/art.33355","volume":"64(2)","author":"Amaral","year":"2012","journal-title":"Arthritis Rheum"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1002\/art.41245","volume":"72","author":"Yang","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.molimm.2018.10.015","volume":"105","author":"Mai","year":"2019","journal-title":"Mol Immunol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e12868","DOI":"10.1111\/cpr.12868","volume":"53","author":"Pan","year":"2020","journal-title":"Cell Prolif"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1002\/art.22732","volume":"56","author":"Williams","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.intimp.2016.12.031","volume":"44","author":"Dinesh","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1136\/annrheumdis-2015-207338","volume":"75","author":"Cumpelik","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1016\/S0140-6736(16)00346-9","volume":"388","author":"Dalbeth","year":"2016","journal-title":"Lancet"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/annrheumdis-2016-209707","volume":"2017;","author":"Richette","journal-title":"Ann Rheum Dis"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.amjmed.2010.09.012","volume":"124","author":"Keenan","year":"2011","journal-title":"Am J Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00281-013-0361-0","volume":"35","author":"Mitroulis","year":"2013","journal-title":"Semin Immunopathol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3109\/08820139.2016.1153651","volume":"45","author":"Cavalcanti","year":"2016","journal-title":"Immunol Invest"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1016\/j.bbrc.2018.08.139","volume":"503","author":"JY","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/jpn.13440","volume":"105","author":"Ma","year":"2021","journal-title":"J Anim Physiol Anim Nutr (Berl)"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/cbf.3598","volume":"39","author":"Cao","year":"2021","journal-title":"Cell Biochem Funct"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1007\/s12035-017-0394-9","volume":"55","author":"Fann","year":"2018","journal-title":"Mol Neurobiol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.4049\/jimmunol.1301974","volume":"192","author":"Ghonime","year":"2014","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.freeradbiomed.2010.01.006","volume":"48","author":"Gill","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"19325-19330","DOI":"10.1074\/jbc.M300498200","volume":"278","author":"Lee","year":"2003","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J. Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci. 2016;73(17):3221\u20133247.doi:10.1007\/s00018-016-2223-0","DOI":"10.1007\/s00018-016-2223-0"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.jbspin.2016.01.006","volume":"83","author":"Yahia","year":"2016","journal-title":"Joint Bone Spine"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=81879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=81879","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T13:10:12Z","timestamp":1656681012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/palmatine-protects-against-msu-induced-gouty-arthritis-via-regulating--peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":43,"URL":"https:\/\/doi.org\/10.2147\/dddt.s356307","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}