{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:14:12Z","timestamp":1793168052112,"version":"4.5.0"},"reference-count":85,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s384155","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T14:45:08Z","timestamp":1668437108000},"page":"3957-3974","source":"Crossref","is-referenced-by-count":207,"title":["Remimazolam: An Updated Review of a New Sedative and Anaesthetic"],"prefix":"10.2147","volume":"Volume 16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8243-343X","authenticated-orcid":true,"given":"Qinxue","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengli","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianying","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1080\/17512433.2021.1901575","volume":"14","author":"Chen","year":"2021","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.neubiorev.2021.05.009","volume":"127","author":"Dominguini","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/S0749-0704(18)30041-1","volume":"11","author":"Barr","year":"1995","journal-title":"Crit Care Clin"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1002\/phar.1806","volume":"36","author":"Wesolowski","year":"2016","journal-title":"Pharmacotherapy"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1097\/00000542-200404000-00008","volume":"100","author":"Mertens","year":"2004","journal-title":"Anesthesiology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1080\/03007995.2018.1519501","volume":"34","author":"Choi","year":"2018","journal-title":"Curr Med Res Opin"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12871-017-0311-9","volume":"17","author":"Kim","year":"2017","journal-title":"BMC Anesthesiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e95","DOI":"10.1016\/j.anclin.2017.01.017","volume":"35","author":"Tanious","year":"2017","journal-title":"Anesthesiol Clin"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1007\/s10620-020-06044-5","volume":"65","author":"Goudra","year":"2020","journal-title":"Dig Dis Sci"},{"key":"ref10","first-page":"1","volume":"4","author":"Whizar","year":"2016","journal-title":"J Anesth Critic Care"},{"key":"ref11","first-page":"929","volume":"13","author":"Rogers","year":"2010","journal-title":"IDrugs"},{"key":"ref12","unstructured":"PAION AG. PAION announces submission of the marketing authorization application for remimazolam in procedural sedation to the European Medicines Agency. PAION AG. Available from: https:\/\/www.paion.com\/. Accessed Nov 20, 2019."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s40265-020-01299-8","volume":"80","author":"Keam","year":"2020","journal-title":"Drugs"},{"key":"ref14","unstructured":"PAION AG. Mundipharma receives market approval for Anerem\u00ae (remimazolam) in general anesthesia in Japan. PAION AG. Available from: https:\/\/www.paion.com\/. Accessed Jan 23, 2020."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"690875","DOI":"10.3389\/fphar.2021.690875","volume":"12","author":"Kilpatrick","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"209","DOI":"10.2334\/josnusd.21-0051","volume":"63","author":"Oka","year":"2021","journal-title":"J Oral Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1213\/ANE.0b013e31823f0c28","volume":"115","author":"Antonik","year":"2012","journal-title":"Anesth Analg"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"388","DOI":"10.4103\/1658-354X.136627","volume":"8","author":"Goudra","year":"2014","journal-title":"Saudi J Anaesth"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1097\/01.anes.0000267503.85085.c0","volume":"107","author":"Kilpatrick","year":"2007","journal-title":"Anesthesiology"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1213\/ANE.0b013e31823acb95","volume":"115","author":"Sneyd","year":"2012","journal-title":"Anesth Analg"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.2147\/DDDT.S186759","volume":"13","author":"Freyer","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1213\/ANE.0b013e318241f68a","volume":"115","author":"Wiltshire","year":"2012","journal-title":"Anesth Analg"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1097\/ALN.0000000000003103","volume":"132","author":"Sch\u00fcttler","year":"2020","journal-title":"Anesthesiology"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1093\/bja\/aeq260","volume":"105","author":"Upton","year":"2010","journal-title":"Br J Anaesth"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.2147\/DDDT.S373772","volume":"16","author":"Deng","year":"2022","journal-title":"Drug Des Devel Ther"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1124\/pr.110.002717","volume":"63","author":"Saari","year":"2011","journal-title":"Pharmacol Rev"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jpba.2017.01.016","volume":"137","author":"Zhou","year":"2017","journal-title":"J Pharm Biomed Anal"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e00851","DOI":"10.1002\/prp2.851","volume":"9","author":"Liu","year":"2021","journal-title":"Pharmacol Res Perspect"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.bja.2021.05.027","volume":"127","author":"St\u00f6hr","year":"2021","journal-title":"Br J Anaesth"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/s40265-021-01544-8","volume":"81","author":"Lee","year":"2021","journal-title":"Drugs"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1002\/jcph.1552","volume":"60","author":"Lohmer","year":"2020","journal-title":"J Clin Pharmacol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00228-019-02800-3","volume":"76","author":"Sheng","year":"2020","journal-title":"Eur J Clin Pharmacol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1093\/bja\/aer441","volume":"108","author":"Iirola","year":"2012","journal-title":"Br J Anaesth"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1213\/ANE.0b013e3182a705ae","volume":"117","author":"Worthington","year":"2013","journal-title":"Anesth Analg"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.giec.2016.02.005","volume":"26","author":"Vicari","year":"2016","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"64","DOI":"10.4166\/kjg.2017.69.1.64","volume":"69","author":"Moon","year":"2017","journal-title":"Korean J Gastroenterol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1213\/ANE.0000000000000548","volume":"120","author":"Borkett","year":"2015","journal-title":"Anesth Analg"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/jgh.15188","volume":"36","author":"Chen","year":"2021","journal-title":"J Gastroenterol Hepatol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1111\/jgh.15761","volume":"37","author":"Tan","year":"2022","journal-title":"J Gastroenterol Hepatol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e936580","DOI":"10.12659\/MSM.936580","volume":"28","author":"Cao","year":"2022","journal-title":"Med Sci Monit"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.gie.2018.04.2351","volume":"88","author":"Rex","year":"2018","journal-title":"Gastrointest Endosc"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.2147\/DDDT.S339535","volume":"15","author":"Liu","year":"2021","journal-title":"Drug Des Devel Ther"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.dld.2020.10.039","volume":"53","author":"Rex","year":"2021","journal-title":"Dig Liver Dis"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1097\/EJA.0000000000001715","volume":"39","author":"Yao","year":"2022","journal-title":"Eur J Anaesthesiol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.chest.2018.09.015","volume":"155","author":"Pastis","year":"2019","journal-title":"Chest"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"813","DOI":"10.3760\/cma.j.cn112137-20200901-02524","volume":"101","author":"Jia","year":"2021","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"902065","DOI":"10.3389\/fphar.2022.902065","volume":"13","author":"Chen","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s00540-020-02755-1","volume":"34","author":"Masui","year":"2020","journal-title":"J Anesth"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00540-020-02788-6","volume":"34","author":"Doi","year":"2020","journal-title":"J Anesth"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00540-020-02776-w","volume":"34","author":"Doi","year":"2020","journal-title":"J Anesth"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.bja.2022.02.040","volume":"129","author":"Chae","year":"2022","journal-title":"Br J Anaesth"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"10595","DOI":"10.12998\/wjcc.v9.i34.10595","volume":"9","author":"Tang","year":"2021","journal-title":"World J Clin Cases"},{"key":"ref53","unstructured":"Wahler S Difference in vasopressor use and usage patterns in patients undergoing cardiac surgery with remimazolam vs propofol\/sevoflurane for general anesthesia. Paper presented at: Anesthesiology. 2015."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/s12871-021-01422-6","volume":"21","author":"Furuta","year":"2021","journal-title":"BMC Anesthesiol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"583","DOI":"10.2147\/IJGM.S345390","volume":"15","author":"Shi","year":"2022","journal-title":"Int J Gen Med"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e0268568","DOI":"10.1371\/journal.pone.0268568","volume":"17","author":"Shimamoto","year":"2022","journal-title":"PLoS One"},{"key":"ref57","unstructured":"Paion UKL, Services OC, Simbec R; Creative Clinical Research Gmb H. Efficacy and safety of remimazolam (CNS7056) compared to propofol for intravenous anesthesia during elective surgery. Available from: https:\/\/clinicaltrials.gov\/show\/NCT03661489. Accessed July 28, 2022."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"386","DOI":"10.14740\/jmc3977","volume":"13","author":"Petkus","year":"2022","journal-title":"J Med Cases"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e28209","DOI":"10.1097\/MD.0000000000028209","volume":"100","author":"Horikoshi","year":"2021","journal-title":"Medicine"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s40981-022-00555-y","volume":"8","author":"Kamata","year":"2022","journal-title":"JA Clin Rep"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s40981-022-00564-x","volume":"8","author":"Yamadori","year":"2022","journal-title":"JA Clin Rep"},{"key":"ref62","unstructured":"Liu H. Remimazolam reduces emergence delirium in preschool children undergoing laparoscopic surgery by sevoflurane anesthesia. Avaliable from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04621305?term=NCT04621305&draw=2&rank=1. Accessed September 28, 2022."},{"key":"ref63","unstructured":"Fox G, Walker JL. Investigation of remimazolam in children undergoing sedation for medical procedures; 2021. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04851717?term=remimazolam&cond=Pediatric&draw=2&rank=1. Accessed September 28, 2022."},{"key":"ref64","unstructured":"Liu H, Cai Y. Intranasal remimazolam for premedication in pediatric patient. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04720963?term=remimazolam&cond=Pediatric&draw=2&rank=2. Accessed September 28, 2022."},{"key":"ref65","unstructured":"Hua F, Fang Y. Effect of remimazolam vs sevoflurane anesthesia on incidence of emergence agitation and complications in children undergoing ophthalmic surgery. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05527314?term=remimazolam&cond=Pediatric&draw=2&rank=3. Accessed September 28, 2022."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40981-022-00528-1","volume":"8","author":"Kitaura","year":"2022","journal-title":"JA Clin Rep"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s40981-022-00514-7","volume":"8","author":"Nishihara","year":"2022","journal-title":"JA Clin Rep"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s40981-021-00454-8","volume":"7","author":"Suzuki","year":"2021","journal-title":"JA Clin Rep"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/jcpt.13525","volume":"47","author":"Zhang","year":"2022","journal-title":"J Clin Pharm Ther"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"735473","DOI":"10.3389\/fmed.2021.735473","volume":"8","author":"Liu","year":"2021","journal-title":"Front Med"},{"key":"ref71","unstructured":"Petersen KU Pre-clinical profile of Remimazolam and pharmacokinetics. 3rd annual meeting of the Japan society for clinical anesthesia.Tokyo, Japan; 2017."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"109899","DOI":"10.1016\/j.jclinane.2020.109899","volume":"66","author":"Zhou","year":"2020","journal-title":"J Clin Anesth"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"173886","DOI":"10.1016\/j.ejphar.2021.173886","volume":"896","author":"Io","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"151","DOI":"10.4266\/acc.2022.00619","volume":"37","author":"Choi","year":"2022","journal-title":"Acute Crit Care"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"832105","DOI":"10.3389\/fmed.2022.832105","volume":"9","author":"Song","year":"2022","journal-title":"Front Med"},{"key":"ref76","unstructured":"Peking Union Medical College H, Yichang Humanwell Pharmaceutical Co L. The availability and safety study of remimazolam besylate for injection on sedation of ERAS patients. Available from: https:\/\/clinicaltrials.gov\/show\/NCT04947345. Accessed July 1, 2022."},{"key":"ref77","unstructured":"Tianjin Nankai H. Remimazolam for sedation in ICU patients undergoing mechanical ventilation. Available from: https:\/\/clinicaltrials.gov\/show\/NCT04815265. Accessed June 30, 2022."},{"key":"ref78","unstructured":"Xuan S. Remazolam toluenesulfonate combined with esketamine for the efficacy and safety of analgesic sedation in ICU patients on mechanical ventilation: a single arm trial clinical study protocol. Available from: http:\/\/www.chictr.org.cn\/showproj.aspx?proj=136350. Accessed July 28, 2022."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12871-022-01713-6","volume":"22","author":"Guo","year":"2022","journal-title":"BMC Anesthesiol"},{"key":"ref80","first-page":"4594","volume":"12","author":"Chen","year":"2020","journal-title":"Am J Transl Res"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"4551","DOI":"10.2147\/DDDT.S334100","volume":"15","author":"Guan","year":"2021","journal-title":"Drug Des Devel Ther"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00540-022-03041-y","volume":"36","author":"Hari","year":"2022","journal-title":"J Anesth"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1002\/jcph.1614","volume":"60","author":"Schippers","year":"2020","journal-title":"J Clin Pharmacol"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1016\/j.bja.2020.11.021","volume":"126","author":"Sasaki","year":"2021","journal-title":"Br J Anaesth"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"e241622","DOI":"10.1136\/bcr-2021-241622","volume":"14","author":"Matsuo","year":"2021","journal-title":"BMJ Case Rep"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=85418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=85418","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T14:45:16Z","timestamp":1668437116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/remimazolam-an-updated-review-of-a-new-sedative-and-anaesthetic-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":85,"URL":"https:\/\/doi.org\/10.2147\/dddt.s384155","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}