{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:41:58Z","timestamp":1792626118070,"version":"4.5.0"},"reference-count":29,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s397971","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T04:05:18Z","timestamp":1683518718000},"page":"1387-1394","source":"Crossref","is-referenced-by-count":8,"title":["Identification of Piperlongumine as Potent Inhibitor of Necroptosis"],"prefix":"10.2147","volume":"Volume 17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-909X","authenticated-orcid":true,"given":"Xiaoyan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0706-2522","authenticated-orcid":true,"given":"Zhi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhong","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17040616","volume":"17","author":"Chen","year":"2016","journal-title":"Int J Mol Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"884","DOI":"10.14348\/molcells.2019.0088","volume":"42","author":"Park","year":"2019","journal-title":"Mol Cells"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/ijms20133220","volume":"20","author":"Choi","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/bjc.2013.810","volume":"110","author":"Makhov","year":"2014","journal-title":"Br J Cancer"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"113471","DOI":"10.1016\/j.ejmech.2021.113471","volume":"220","author":"Zhu","year":"2021","journal-title":"Eur J Med Chem"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"9714","DOI":"10.1073\/pnas.1901179116","volume":"116","author":"Degterev","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41583-018-0093-1","volume":"20","author":"Yuan","year":"2019","journal-title":"Nat Rev Neurosci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nrm.2016.149","volume":"18","author":"Weinlich","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1101\/gad.312561.118","volume":"32","author":"Shan","year":"2018","journal-title":"Genes Dev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/s41596-019-0280-1","volume":"15","author":"Kouprina","year":"2020","journal-title":"Nat Protoc"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3729","DOI":"10.3390\/molecules26123729","volume":"26","author":"Musalov","year":"2021","journal-title":"Molecules"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"330","DOI":"10.3390\/md16090330","volume":"16","author":"Zhang","year":"2018","journal-title":"Mar Drugs"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/s41419-020-2534-9","volume":"11","author":"Wu","year":"2020","journal-title":"Cell Death Dis"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41467-017-00406-w","volume":"8","author":"Geng","year":"2017","journal-title":"Nat Commun"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1038\/s41467-020-15466-8","volume":"11","author":"Laurien","year":"2020","journal-title":"Nat Commun"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"5796","DOI":"10.3390\/ijms22115796","volume":"22","author":"Shimada","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"E2001","DOI":"10.1073\/pnas.1722013115","volume":"115","author":"Meng","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nature13608","volume":"513","author":"Dannappel","year":"2014","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e437","DOI":"10.1038\/cddis.2012.176","volume":"3","author":"Takahashi","year":"2012","journal-title":"Cell Death Dis"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/s41423-019-0237-x","volume":"17","author":"Yang","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1128\/IAI.00742-09","volume":"79","author":"Murapa","year":"2011","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1007\/s11845-016-1525-4","volume":"186","author":"Heffernan","year":"2017","journal-title":"Ir J Med Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1007\/s00134-015-3906-y","volume":"41","author":"Rhodes","year":"2015","journal-title":"Intensive Care Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.intimp.2014.09.016","volume":"23","author":"Yang","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s10495-022-01711-6","volume":"27","author":"Awasthee","year":"2022","journal-title":"Apoptosis"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.3892\/ijmm.2019.4322","volume":"44","author":"Lu","year":"2019","journal-title":"Int J Mol Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e24452","DOI":"10.1002\/jcla.24452","volume":"36","author":"Pan","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1093\/neuonc\/nou088","volume":"16","author":"Kim","year":"2014","journal-title":"Neuro Oncol"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=89525","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=89525","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T04:05:19Z","timestamp":1683518719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/identification-of-piperlongumine-as-potent-inhibitor-of-necroptosis-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":29,"URL":"https:\/\/doi.org\/10.2147\/dddt.s397971","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]}}}