{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:54:13Z","timestamp":1789325653210,"version":"build-2803163510"},"reference-count":70,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s398625","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T08:40:07Z","timestamp":1677919207000},"page":"675-690","source":"Crossref","is-referenced-by-count":17,"title":["Wuling San Based on Network Pharmacology and in vivo Evidence Against Hyperuricemia via Improving Oxidative Stress and Inhibiting Inflammation"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Jing","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-068X","authenticated-orcid":true,"given":"Zhijian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-5142","authenticated-orcid":true,"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s41256-020-00178-9","volume":"5","author":"Huang","year":"2020","journal-title":"Glob Health Res Policy"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/s41371-020-00455-7","volume":"35","author":"Qian","year":"2021","journal-title":"J Hum Hypertens"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.3390\/jcm10091829","volume":"10","author":"We\u0142nicki","year":"2021","journal-title":"J Clin Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"6681","DOI":"10.1038\/s41598-019-43241-3","volume":"9","author":"Oh","year":"2019","journal-title":"Sci Rep"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"9973862","DOI":"10.1155\/2021\/9973862","volume":"2021","author":"Hussain","year":"2021","journal-title":"J Diabetes Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"4314","DOI":"10.1038\/s41598-018-22570-9","volume":"8","author":"Song","year":"2018","journal-title":"Sci Rep"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12944-019-1031-6","volume":"18","author":"Hou","year":"2019","journal-title":"Lipids Health Dis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s12020-022-02979-z","volume":"76","author":"Chen","year":"2022","journal-title":"Endocrine"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1080\/17843286.2020.1783907","volume":"77","author":"Catanzaro","year":"2022","journal-title":"Acta Clin Belg"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.semnephrol.2011.08.007","volume":"31","author":"Doehner","year":"2011","journal-title":"Semin Nephrol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"7432797","DOI":"10.1155\/2016\/7432797","volume":"2016","author":"Hussain","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"63520","DOI":"10.1007\/s11356-022-20274-2","volume":"29","author":"Elgebaly","year":"2022","journal-title":"Environ Sci Pollut Res Int"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"641136","DOI":"10.3389\/fcvm.2021.641136","volume":"8","author":"Deng","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1536\/ihj.16-192","volume":"57","author":"Maharani","year":"2016","journal-title":"Int Heart J"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"39","DOI":"10.2147\/tcrm.S232033","volume":"16","author":"Albu","year":"2020","journal-title":"Ther Clin Risk Manag"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1002\/acr.24180","volume":"72","author":"FitzGerald","year":"2020","journal-title":"Arthritis Care Res"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"i35","DOI":"10.1093\/rheumatology\/kex422","volume":"57","author":"Stamp","year":"2018","journal-title":"Rheumatology"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e932921","DOI":"10.12659\/ajcr.932921","volume":"22","author":"Hoyer","year":"2021","journal-title":"Am J Case Rep"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3390\/ph11020051","volume":"11","author":"Jordan","year":"2018","journal-title":"Pharmaceuticals"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1080\/14740338.2019.1594771","volume":"18","author":"Strilchuk","year":"2019","journal-title":"Expert Opin Drug Saf"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/antiox10040564","volume":"10","author":"Chang","year":"2021","journal-title":"Antioxidants"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"109195","DOI":"10.1016\/j.biopha.2019.109195","volume":"118","author":"Chen","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/molecules26237307","volume":"26","author":"Zhang","year":"2021","journal-title":"Molecules"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/s1875-5364(16","volume":"14","author":"Wang","year":"2016","journal-title":"Chin J Nat Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1016\/j.fct.2007.12.005","volume":"46","author":"He","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jep.2015.04.011","volume":"169","author":"Yang","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/s1875-5364(13","volume":"11","author":"Ding","year":"2013","journal-title":"Chin J Nat Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/1472-6882-14-242","volume":"14","author":"Oh","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"731969","DOI":"10.1155\/2013\/731969","volume":"2013","author":"Yang","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"138460","DOI":"10.1155\/2014\/138460","volume":"2014","author":"Li","year":"2014","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1758-2946-6-13","volume":"6","author":"Ru","year":"2014","journal-title":"J Cheminform"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"D1110","DOI":"10.1093\/nar\/gky1021","volume":"47","author":"Wu","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"W32","DOI":"10.1093\/nar\/gku293","volume":"42","author":"Gfeller","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"D789","DOI":"10.1093\/nar\/gku1205","volume":"43","author":"Amberger","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"D1031","DOI":"10.1093\/nar\/gkz981","volume":"48","author":"Wang","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"D845","DOI":"10.1093\/nar\/gkz1021","volume":"48","author":"Pi\u00f1ero","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"baq020","DOI":"10.1093\/database\/baq020","volume":"2010","author":"Safran","year":"2010","journal-title":"Database"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1107\/s0907444998009378","volume":"54","author":"Sussman","year":"1998","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"6642584","DOI":"10.1155\/2021\/6642584","volume":"2021","author":"Han","year":"2021","journal-title":"Biomed Res Int"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"793888","DOI":"10.3389\/fphar.2022.793888","volume":"13","author":"Cao","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"791983","DOI":"10.3389\/fimmu.2021.791983","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.semarthrit.2020.12.001","volume":"51","author":"Pathmanathan","year":"2021","journal-title":"Semin Arthritis Rheum"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1002\/art.40807","volume":"71","author":"Chen-Xu","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1080\/14656566.2017.1349099","volume":"18","author":"Soskind","year":"2017","journal-title":"Expert Opin Pharmacother"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/fmed.2018.00160","volume":"5","author":"Benn","year":"2018","journal-title":"Front Med"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"199","DOI":"10.4314\/ajtcam.v10i5.1","volume":"10","author":"Lin","year":"2013","journal-title":"Afr J Tradit Complement Altern Med"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1142\/s0192415x07005041","volume":"35","author":"Chen","year":"2007","journal-title":"Am J Chin Med"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3390\/biom10020199","volume":"10","author":"Alam","year":"2020","journal-title":"Biomolecules"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jtcme.2019.02.004","volume":"10","author":"Lodhi","year":"2020","journal-title":"J Tradit Complement Med"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1002\/iub.2066","volume":"71","author":"Alekhya Sita","year":"2019","journal-title":"IUBMB Life"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/sj.bjp.0706972","volume":"150","author":"Kobori","year":"2007","journal-title":"Br J Pharmacol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"107317","DOI":"10.1016\/j.intimp.2020.107317","volume":"93","author":"Duan","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.jep.2012.06.012","volume":"142","author":"de Souza","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s40256-020-00459-1","volume":"21","author":"Kaul","year":"2021","journal-title":"Am J Cardiovasc Drugs"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"700","DOI":"10.2174\/1381612825666190408122557","volume":"25","author":"Zhang","year":"2019","journal-title":"Curr Pharm Des"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e13108","DOI":"10.1097\/md.0000000000013108","volume":"97","author":"Zhou","year":"2018","journal-title":"Medicine"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1002\/acr.23549","volume":"70","author":"Estevez-Garcia","year":"2018","journal-title":"Arthritis Care Res"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/rheumatology\/keaa425","volume":"60","author":"Luis-Rodr\u00edguez","year":"2021","journal-title":"Rheumatology"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"576","DOI":"10.3390\/biom10040576","volume":"10","author":"Mart\u00ednez-Reyes","year":"2020","journal-title":"Biomolecules"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1080\/14397595.2017.1369924","volume":"28","author":"Yokose","year":"2018","journal-title":"Mod Rheumatol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1080\/14397595.2020.1740410","volume":"31","author":"Temmoku","year":"2021","journal-title":"Mod Rheumatol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3892\/mmr.2021.12368","volume":"24","author":"Li","year":"2021","journal-title":"Mol Med Rep"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"8023","DOI":"10.1007\/s11033-021-06840-w","volume":"48","author":"Nie","year":"2021","journal-title":"Mol Biol Rep"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.3390\/md19050238","volume":"19","author":"Zhang","year":"2021","journal-title":"Mar Drugs"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.ijcard.2014.07.102","volume":"176","author":"Oberbach","year":"2014","journal-title":"Int J Cardiol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1002\/ddr.21699","volume":"81","author":"Wang","year":"2020","journal-title":"Drug Dev Res"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.2147\/dddt.S247091","volume":"14","author":"Wang","year":"2020","journal-title":"Drug Des Devel Ther"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=87906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=87906","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T08:40:09Z","timestamp":1677919209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/wuling-san-based-on-network-pharmacology-and-in-vivo-evidence-against--peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":70,"URL":"https:\/\/doi.org\/10.2147\/dddt.s398625","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}