{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:48:02Z","timestamp":1792237682512,"version":"4.4.0"},"reference-count":59,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s406568","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T01:00:09Z","timestamp":1688000409000},"page":"1945-1957","source":"Crossref","is-referenced-by-count":76,"title":["The Effect of Low-Dose Esketamine on Postoperative Neurocognitive Dysfunction in Elderly Patients Undergoing General Anesthesia for Gastrointestinal Tumors: A Randomized Controlled Trial"],"prefix":"10.2147","volume":"Volume 17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7110-4013","authenticated-orcid":true,"given":"Jiamin","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuquan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanglong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1097\/ALN.0b013e318195b569","volume":"110","author":"Steinmetz","year":"2009","journal-title":"Anesthesiology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/aln.0000000000002956","volume":"132","author":"Eckenhoff","year":"2020","journal-title":"Anesthesiology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.bja.2017.11.087","volume":"121","author":"Evered","year":"2018","journal-title":"Br J Anaesth"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1097\/aln.0000000000002729","volume":"131","author":"Daiello","year":"2019","journal-title":"Anesthesiology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1213\/ane.0000000000005525","volume":"132","author":"Snyder","year":"2021","journal-title":"Anesth Analg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.2147\/cmar.S149619","volume":"10","author":"Sitarz","year":"2018","journal-title":"Cancer Manag Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/jso.23262","volume":"107","author":"Guggenheim","year":"2013","journal-title":"J Surg Oncol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/s0140-6736(19)32319-0","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.cgh.2019.07.045","volume":"18","author":"Thrift","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s41575-019-0189-8","volume":"16","author":"Keum","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1053\/j.gastro.2018.08.063","volume":"156","author":"Peery","year":"2019","journal-title":"Gastroenterology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jcrc.2016.10.026","volume":"38","author":"Liu","year":"2017","journal-title":"J Crit Care"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"206","DOI":"10.2174\/1566524015666150330143008","volume":"15","author":"Ohgi","year":"2015","journal-title":"Curr Mol Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.2147\/dddt.S224553","volume":"13","author":"Wang","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e674","DOI":"10.4088\/JCP.17f11681","volume":"78","author":"Andrade","year":"2017","journal-title":"J Clin Psychiatry"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1177\/2045125316631267","volume":"6","author":"Muller","year":"2016","journal-title":"Ther Adv Psychopharmacol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.biopsych.2015.10.018","volume":"80","author":"Singh","year":"2016","journal-title":"Biol Psychiatry"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","volume":"184","author":"Karki","year":"2021","journal-title":"Cell"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0895-4356(88)90034-0","volume":"41","author":"Katzman","year":"1988","journal-title":"J Clin Epidemiol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1097\/eja.0000000000000594","volume":"34","author":"Aldecoa","year":"2017","journal-title":"Eur J Anaesthesiol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.bja.2021.07.021","volume":"127","author":"Evered","year":"2021","journal-title":"Br J Anaesth"},{"key":"ref23","first-page":"1069","volume":"82","author":"Bornemann-Cimenti","year":"2016","journal-title":"Minerva Anestesiol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1001\/jama.2011.2005","volume":"307","author":"Lyketsos","year":"2012","journal-title":"JAMA"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.aan.2010.09.003","volume":"28","author":"Tsai","year":"2010","journal-title":"Adv Anesth"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/01.JGP.0000229792.31009.da","volume":"15","author":"Wang","year":"2007","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1097\/sla.0000000000001900","volume":"265","author":"O\u2019Brien","year":"2017","journal-title":"Ann Surg"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.amjms.2018.10.012","volume":"357","author":"Gao","year":"2019","journal-title":"Am J Med Sci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12871-018-0676-4","volume":"19","author":"Zhang","year":"2019","journal-title":"BMC Anesthesiol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/01.anes.0000296071.19434.1e","volume":"108","author":"Monk","year":"2008","journal-title":"Anesthesiology"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1213\/ANE.0b013e318215217e","volume":"112","author":"Evered","year":"2011","journal-title":"Anesth Analg"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/s00540-012-1326-5","volume":"26","author":"Abelha","year":"2012","journal-title":"J Anesth"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1093\/bja\/aet420","volume":"112","author":"Nadelson","year":"2014","journal-title":"Br J Anaesth"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12871-021-01405-7","volume":"21","author":"Li","year":"2021","journal-title":"BMC Anesthesiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1002\/bjs.10062","volume":"103","author":"Scholz","year":"2016","journal-title":"Br J Surg"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/pan.13315","volume":"28","author":"Schmitz","year":"2018","journal-title":"Paediatr Anaesth"},{"key":"ref37","first-page":"1701","volume":"13","author":"Tu","year":"2021","journal-title":"Am J Transl Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejphar.2012.11.023","volume":"698","author":"Moaddel","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1097\/ALN.0b013e3181ed09a2","volume":"113","author":"Domino","year":"2010","journal-title":"Anesthesiology"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.bja.2019.01.013","volume":"122","author":"Sessler","year":"2019","journal-title":"Br J Anaesth"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.ejcts.2010.11.024","volume":"40","author":"Siepe","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/s0896-6273(00)80987-3","volume":"20","author":"Milner","year":"1998","journal-title":"Neuron"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.neuron.2004.09.012","volume":"44","author":"Malenka","year":"2004","journal-title":"Neuron"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.3906\/sag-1405-87","volume":"45","author":"I\u015fik","year":"2015","journal-title":"Turk J Med Sci"},{"key":"ref45","first-page":"1202","volume":"63","author":"Uchino","year":"2014","journal-title":"Masui"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12871-018-0501-0","volume":"18","author":"Zhang","year":"2018","journal-title":"BMC Anesthesiol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.neubiorev.2020.11.020","volume":"120","author":"Gill","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1213\/ane.0000000000004194","volume":"129","author":"Wu","year":"2019","journal-title":"Anesth Analg"},{"key":"ref49","first-page":"669","volume":"82","author":"Orena","year":"2016","journal-title":"Minerva Anestesiol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1097\/MCC.0b013e328348bece","volume":"17","author":"Monk","year":"2011","journal-title":"Curr Opin Crit Care"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1097\/EJA.0b013e328349b7f5","volume":"28","author":"Steiner","year":"2011","journal-title":"Eur J Anaesthesiol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1213\/ANE.0b013e3182147f6d","volume":"112","author":"Rudolph","year":"2011","journal-title":"Anesth Analg"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1111\/anae.12711","volume":"69","author":"Escallier","year":"2014","journal-title":"Anaesthesia"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e01238","DOI":"10.1002\/brb3.1238","volume":"9","author":"Quan","year":"2019","journal-title":"Brain Behav"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1213\/01.ane.0000228870.48028.b5","volume":"103","author":"Farag","year":"2006","journal-title":"Anesth Analg"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1097\/aln.0000000000003159","volume":"132","author":"Ballesteros","year":"2020","journal-title":"Anesthesiology"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.neuropharm.2018.04.022","volume":"137","author":"Amat-Foraster","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13604","author":"Li","year":"2022","journal-title":"J Clin Pharm Ther"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1097\/00000542-199905000-00006","volume":"90","author":"Roach","year":"1999","journal-title":"Anesthesiology"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=90819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=90819","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T01:00:12Z","timestamp":1688000412000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-effect-of-low-dose-esketamine-on-postoperative-neurocognitive-dysf-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":59,"URL":"https:\/\/doi.org\/10.2147\/dddt.s406568","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]}}}