{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:33:45Z","timestamp":1777581225728,"version":"3.51.4"},"reference-count":32,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s412743","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T06:40:05Z","timestamp":1702276805000},"page":"3709-3722","source":"Crossref","is-referenced-by-count":3,"title":["Identification of cholest-4-ene-3,6-dione as a Novel Neuroprotectant in Ischemic Stroke and Its Lipidomics"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Xiaoshuai","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3618-2809","authenticated-orcid":true,"given":"Feng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaogang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guolei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenji","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2023,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/s0140-6736(19)30427-1","volume":"394","author":"Zhou","year":"2019","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"5815843","DOI":"10.1155\/2022\/5815843","volume":"2022","author":"Su","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27134181","volume":"27","author":"Liu","year":"2022","journal-title":"Molecules"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-022-01078-5","author":"Tang","year":"2022","journal-title":"Transl Stroke Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"988283","DOI":"10.3389\/fnins.2022.988283","volume":"16","author":"Gu","year":"2022","journal-title":"Front Neurosci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/s41419-022-05159-z","volume":"13","author":"Kopach","year":"2022","journal-title":"Cell Death Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.3390\/ph14101001","volume":"14","author":"Sillapachaiyaporn","year":"2021","journal-title":"Pharmaceuticals"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/j.1471-4159.2011.07593.x","volume":"120","author":"Zhou","year":"2012","journal-title":"J Neurochem"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"6124","DOI":"10.3390\/molecules26206124","volume":"26","author":"Borozdenko","year":"2021","journal-title":"Molecules"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"11426","DOI":"10.1523\/jneurosci.0344-14.2014","volume":"34","author":"Hu","year":"2014","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1016\/s0968-0896(02)00006-8","volume":"10","author":"Qi","year":"2002","journal-title":"Bioorg Med Chem"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fnmol.2020.00028","volume":"13","author":"Wu","year":"2020","journal-title":"Front Mol Neurosci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.bbi.2020.06.019","volume":"88","author":"Wang","year":"2020","journal-title":"Brain Behav Immun"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s11064-017-2346-1","volume":"44","author":"Blumrich","year":"2019","journal-title":"Neurochem Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1021\/acscentsci.0c01592","volume":"7","author":"Fang","year":"2021","journal-title":"ACS Cent Sci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1161\/strokeaha.119.026652","volume":"50","author":"Bieber","year":"2019","journal-title":"Stroke"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"6787","DOI":"10.1523\/jneurosci.2352-17.2018","volume":"38","author":"Matei","year":"2018","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"108816","DOI":"10.1016\/j.biopha.2019.108816","volume":"115","author":"Zhang","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1080\/15548627.2020.1712108","volume":"16","author":"Lee","year":"2020","journal-title":"Autophagy"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3390\/antiox8080261","volume":"8","author":"Kushairi","year":"2019","journal-title":"Antioxidants"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"112636","DOI":"10.1016\/j.jep.2020.112636","volume":"253","author":"Sun","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"991281","DOI":"10.3389\/fphar.2022.991281","volume":"13","author":"Liu","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"113708","DOI":"10.1016\/j.jpba.2020.113708","volume":"193","author":"Sun","year":"2021","journal-title":"J Pharm Biomed Anal"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1080\/10715760400017343","volume":"38","author":"Garc\u00eda-Santos","year":"2004","journal-title":"Free Radic Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/cdd.2010.92","volume":"18","author":"Tobaben","year":"2011","journal-title":"Cell Death Differ"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"6237","DOI":"10.3390\/molecules17066237","volume":"17","author":"Chompoo","year":"2012","journal-title":"Molecules"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"11261","DOI":"10.3390\/app112311261","volume":"11","author":"Lee","year":"2021","journal-title":"Appl Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"108638","DOI":"10.1016\/j.steroids.2020.108638","volume":"159","author":"Sali","year":"2020","journal-title":"Steroids"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e52797","DOI":"10.1371\/journal.pone.0052797","volume":"8","author":"Tayade","year":"2013","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/med.21817","volume":"42","author":"Tuo","year":"2022","journal-title":"Med Res Rev"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1016\/s0960-894x(98)00362-x","volume":"8","author":"Suzuki","year":"1998","journal-title":"Bioorg Med Chem Lett"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"6520","DOI":"10.1007\/s12035-021-02537-0","volume":"58","author":"Zhao","year":"2021","journal-title":"Mol Neurobiol"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=95120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=95120","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T06:40:08Z","timestamp":1702276808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/identification-of-cholest-4-ene-36-dione-as-a-novel-neuroprotectant-in-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":32,"URL":"https:\/\/doi.org\/10.2147\/dddt.s412743","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]}}}