{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:20:34Z","timestamp":1783948834035,"version":"3.55.0"},"reference-count":51,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s429180","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T06:20:07Z","timestamp":1701066007000},"page":"3507-3522","source":"Crossref","is-referenced-by-count":11,"title":["Recombinant Human Adenovirus Type 5 (H101) Intra-Tumor Therapy in Patients with Persistent, Recurrent, or Metastatic Cervical Cancer: Genomic Profiling Relating to Clinical Efficacy"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Qiying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1080\/14712598.2019.1646721","volume":"19","author":"Marret","year":"2019","journal-title":"Expert Opin Biol Ther"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1200\/JCO.2014.58.9093","volume":"33","author":"Stevanovic","year":"2015","journal-title":"J Clin Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1126\/science.aak9510","volume":"356","author":"Stevanovic","year":"2017","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S1470-2045(16)30066-3","volume":"17","author":"Seiwert","year":"2016","journal-title":"Lancet Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1136\/thx.2009.117572","volume":"65","author":"Gong","year":"2010","journal-title":"Thorax"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1200\/JCO.18.01265","volume":"37","author":"Chung","year":"2019","journal-title":"J Clin Oncol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMoa2112435","volume":"385","author":"Colombo","year":"2021","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.trecan.2022.10.003","volume":"9","author":"Ma","year":"2023","journal-title":"Trends Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2017.08.027","volume":"170","author":"Ribas","year":"2017","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.omto.2022.03.003","volume":"25","author":"Zhang","year":"2022","journal-title":"Mol Ther Oncolytics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1200\/JCO.2017.73.7379","volume":"36","author":"Chesney","year":"2018","journal-title":"J Clin Oncol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"5696","DOI":"10.1158\/1078-0432.CCR-16-3232","volume":"23","author":"Mell","year":"2017","journal-title":"Clin Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"752504","DOI":"10.3389\/fonc.2021.752504","volume":"11","author":"Zhang","year":"2021","journal-title":"Front Oncol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1186\/s12885-015-1715-x","volume":"15","author":"Lin","year":"2015","journal-title":"BMC Cancer"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1111\/1759-7714.13947","volume":"12","author":"Zhang","year":"2021","journal-title":"Thorac Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"877155","DOI":"10.3389\/fonc.2022.877155","volume":"12","author":"Zhang","year":"2022","journal-title":"Front Oncol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature12881","volume":"506","author":"Ojesina","year":"2014","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1200\/JCO.19.03010","volume":"38","author":"Flaherty","year":"2020","journal-title":"J Clin Oncol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/IGC.0000000000001216","volume":"28","author":"Cibula","year":"2018","journal-title":"Int J Gynecol Cancer"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1056\/NEJMoa2112187","volume":"386","author":"Tewari","year":"2022","journal-title":"N Engl J Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1200\/JCO.21.02091","volume":"40","author":"Xu","year":"2022","journal-title":"J Clin Oncol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1126\/science.abk3436","volume":"374","author":"Melcher","year":"2021","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41573-022-00493-5","volume":"21","author":"Kim","year":"2022","journal-title":"Nature Rev Drug Discovery"},{"key":"ref24","volume":"9","author":"Huang","year":"2021","journal-title":"J Immunother Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1111\/cas.14148","volume":"110","author":"Tamura","year":"2019","journal-title":"Cancer Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ccell.2020.10.001","volume":"39","author":"Jardim","year":"2021","journal-title":"Cancer Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"6349):409","DOI":"10.1126\/science.aan6733","volume":"357","author":"Le","year":"2017","journal-title":"Science"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13048-019-0494-4","volume":"12","author":"Zhang","year":"2019","journal-title":"J Ovarian Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1089\/dna.2020.5823","volume":"40","author":"Zou","year":"2021","journal-title":"DNA Cell Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.21037\/atm-22-301","volume":"10","author":"Liu","year":"2022","journal-title":"Ann Translational Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41379-020-0614-0","volume":"34","author":"Park","year":"2021","journal-title":"Mod Pathol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ygyno.2020.06.482","volume":"158","author":"Prieske","year":"2020","journal-title":"Gynecol Oncol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12920-022-01376-9","volume":"15","author":"Liu","year":"2022","journal-title":"BMC Med Genomics"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1111\/cas.14524","volume":"111","author":"Saito","year":"2020","journal-title":"Cancer Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"11632","DOI":"10.1038\/s41598-022-15866-4","volume":"12","author":"Tian","year":"2022","journal-title":"Sci Rep"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1093\/abbs\/gmab113","volume":"53","author":"Wei","year":"2021","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/cge.14146","volume":"102","author":"Gao","year":"2022","journal-title":"Clin Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.26508\/lsa.201900582","volume":"2","author":"Van Duzer","year":"2019","journal-title":"Life Science Alliance"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4149\/neo_2018_181029N805","volume":"66","author":"Liu","year":"2019","journal-title":"Neoplasma"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000502861","volume":"4","author":"van der Lely","year":"2019","journal-title":"Inflammatory Intestinal Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/hep4.1400","volume":"3","author":"Jariwala","year":"2019","journal-title":"Hepatology commun"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/01443615.2020.1716310","volume":"41","author":"Yamada","year":"2021","journal-title":"J Obstet Gynaecol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3109\/07357907.2010.483511","volume":"28","author":"Springwald","year":"2010","journal-title":"Cancer Invest"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc3599","volume":"13","author":"Holohan","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrc3261","volume":"12","author":"Marusyk","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/gm505","volume":"5","author":"de Bruin","year":"2013","journal-title":"Genome Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature12625","volume":"501","author":"Burrell","year":"2013","journal-title":"Nature"},{"key":"ref48","first-page":"259","volume":"301","author":"Pfeifer","year":"2006","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature21386","volume":"543","author":"Huang","year":"2017","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41588-020-0673-7","volume":"52","author":"Gagliardi","year":"2020","journal-title":"Nat Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1038\/s41467-019-12594-8","volume":"10","author":"Christensen","year":"2019","journal-title":"Nat Commun"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=94693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=94693","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T06:20:33Z","timestamp":1701066033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/recombinant-human-adenovirus-type-5-h101-intra-tumor-therapy-in-patien-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":51,"URL":"https:\/\/doi.org\/10.2147\/dddt.s429180","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]}}}