{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:05Z","timestamp":1791229445728,"version":"4.1.0"},"reference-count":56,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s481173","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:50:25Z","timestamp":1732683025000},"page":"5461-5472","source":"Crossref","is-referenced-by-count":13,"title":["Effects of Esketamine Combined with Dexmedetomidine on Early Postoperative Cognitive Function in Elderly Patients Undergoing Lumbar Spinal Surgery: A Double-Blind Randomized Controlled Clinical Trial"],"prefix":"10.2147","volume":"Volume 18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8381-0178","authenticated-orcid":true,"given":"Qing-Yu","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0784-077X","authenticated-orcid":true,"given":"Dong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7901-5769","authenticated-orcid":true,"given":"Rui-Ning","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-3116","authenticated-orcid":true,"given":"Jing-Yi","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rende","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4053-5942","authenticated-orcid":true,"given":"Jun-Ma","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1213\/ANE.0000000000003514","volume":"127","author":"Evered","year":"2018","journal-title":"Anesth Analg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/cns.13763","volume":"28","author":"Liu","year":"2022","journal-title":"CNS Neurosci Ther"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/s0140-6736(97)07382-0","volume":"351","author":"Moller","year":"1998","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1111\/ajt.14570","volume":"18","author":"Smith","year":"2018","journal-title":"Am J Transplant"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1097\/ALN.0b013e318195b569","volume":"110","author":"Steinmetz","year":"2009","journal-title":"Anesthesiology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.2147\/jmdh.S431168","volume":"16","author":"Arefayne","year":"2023","journal-title":"J Multidiscip Healthc"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e101815","DOI":"10.5812\/aapm.101815","volume":"10","author":"Ehsani","year":"2020","journal-title":"Anesth Pain Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1056\/NEJMoa2304145","volume":"389","author":"Reif","year":"2023","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1001\/jamapsychiatry.2019.1189","volume":"76","author":"Daly","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.2147\/dddt.S224553","volume":"13","author":"Wang","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.2147\/dddt.S406568","volume":"17","author":"Ma","year":"2023","journal-title":"Drug Des Devel Ther"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"110437","DOI":"10.1016\/j.jclinane.2021.110437","volume":"75","author":"Massoth","year":"2021","journal-title":"J Clin Anesth"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s13018-023-03728-2","volume":"18","author":"Min","year":"2023","journal-title":"J Orthop Surg Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"863","DOI":"10.2147\/dddt.S401161","volume":"17","author":"Han","year":"2023","journal-title":"Drug Des Devel Ther"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"5680","DOI":"10.1007\/s12035-023-03860-4","volume":"61","author":"Wen","year":"2024","journal-title":"Mol Neurobiol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jad.2022.03.072","volume":"307","author":"Wang","year":"2022","journal-title":"J Affect Disord"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e36754","DOI":"10.1097\/md.0000000000036754","volume":"102","author":"Yang","year":"2023","journal-title":"Medicine"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1164\/rccm.202206-1208OC","volume":"207","author":"Shehabi","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.bbi.2020.10.008","volume":"91","author":"Mei","year":"2021","journal-title":"Brain Behav Immun"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1123089","DOI":"10.3389\/fnagi.2023.1123089","volume":"15","author":"Liao","year":"2023","journal-title":"Front Aging Neurosci"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1021\/acschemneuro.2c00173","volume":"13","author":"Wang","year":"2022","journal-title":"ACS Chem Neurosci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/js9.0000000000000001","volume":"109","author":"Zeng","year":"2023","journal-title":"Int J Surg"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1213\/ane.0000000000006464","volume":"136","author":"Niu","year":"2023","journal-title":"Anesth Analg"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1136\/rapm-2023-104415","volume":"49","author":"Kim","year":"2024","journal-title":"Reg Anesth Pain Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.3389\/fphar.2018.01007","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Pharmacol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"110955","DOI":"10.1016\/j.jclinane.2022.110955","volume":"82","author":"Choi","year":"2022","journal-title":"J Clin Anesth"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.2147\/dddt.S407905","volume":"17","author":"Li","year":"2023","journal-title":"Drug Des Devel Ther"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/cns.12099","volume":"19","author":"Mion","year":"2013","journal-title":"CNS Neurosci Ther"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e27389","DOI":"10.7759\/cureus.27389","volume":"14","author":"Rueda Carrillo","year":"2022","journal-title":"Cureus"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"114436","DOI":"10.1016\/j.expneurol.2023.114436","volume":"366","author":"Tang","year":"2023","journal-title":"Exp Neurol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"114646","DOI":"10.1016\/j.expneurol.2023.114646","volume":"372","author":"Wang","year":"2024","journal-title":"Exp Neurol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"7507","DOI":"10.2147\/jir.S346089","volume":"14","author":"Liu","year":"2021","journal-title":"J Inflamm Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/aln.0000000000004438","volume":"138","author":"Shin","year":"2023","journal-title":"Anesthesiology"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"251","DOI":"10.33549\/physiolres.934983","volume":"72","author":"Zhi","year":"2023","journal-title":"Physiol Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1186\/s40001-023-01265-6","volume":"28","author":"Wang","year":"2023","journal-title":"Eur J Med Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1198216","DOI":"10.3389\/fneur.2023.1198216","volume":"14","author":"Brunelli","year":"2023","journal-title":"Front Neurol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1080\/01616412.1998.11740541","volume":"20","author":"Erg\u00fcn","year":"1998","journal-title":"Neurol Res"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1186\/s12877-023-03986-z","volume":"23","author":"Gao","year":"2023","journal-title":"BMC Geriatr"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"20057","DOI":"10.1038\/s41598-023-47267-6","volume":"13","author":"Yuguero","year":"2023","journal-title":"Sci Rep"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"3752","DOI":"10.1007\/s00415-022-11004-2","volume":"269","author":"Hanin","year":"2022","journal-title":"J Neurol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"e0284728","DOI":"10.1371\/journal.pone.0284728","volume":"18","author":"Wang","year":"2023","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1097\/eja.0000000000000450","volume":"33","author":"Silva","year":"2016","journal-title":"Eur J Anaesthesiol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e25446","DOI":"10.1097\/md.0000000000025446","volume":"100","author":"Wan","year":"2021","journal-title":"Medicine"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.neubiorev.2016.05.009","volume":"68","author":"Kawata","year":"2016","journal-title":"Neurosci Biobehav Rev"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/s0197-4580(01)00293-7","volume":"22","author":"Mrak","year":"2001","journal-title":"Neurobiol Aging"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.jclinane.2017.02.007","volume":"38","author":"Geng","year":"2017","journal-title":"J Clin Anesth"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41419-019-1416-5","volume":"10","author":"Sun","year":"2019","journal-title":"Cell Death Dis"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"110440","DOI":"10.1016\/j.intimp.2023.110440","volume":"121","author":"Zhong","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"714","DOI":"10.24976\/Discov.Med.202436183.67","volume":"36","author":"Zhao","year":"2024","journal-title":"Discov Med"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"969","DOI":"10.2460\/ajvr.80.10.969","volume":"80","author":"Dent","year":"2019","journal-title":"Am J Vet Res"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.2147\/dddt.S422896","volume":"17","author":"Huang","year":"2023","journal-title":"Drug Des Devel Ther"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1213\/ane.0000000000001226","volume":"122","author":"Naik","year":"2016","journal-title":"Anesth Analg"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1111\/bcp.15726","volume":"89","author":"Wang","year":"2023","journal-title":"Br J Clin Pharmacol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s44254-023-00039-x","volume":"2","author":"Zhang","year":"2024","journal-title":"Anesthesiol Perioper Sci"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"20220816","DOI":"10.1515\/biol-2022-0816","volume":"19","author":"Wang","year":"2024","journal-title":"Open Life Sci"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.bja.2023.10.038","volume":"132","author":"Duan","year":"2024","journal-title":"Br J Anaesth"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/97760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/97760","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:50:27Z","timestamp":1732683027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/effects-of-esketamine-combined-with-dexmedetomidine-on-early-postopera-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":56,"URL":"https:\/\/doi.org\/10.2147\/dddt.s481173","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]}}}