{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:52:09Z","timestamp":1792533129441,"version":"4.5.0"},"reference-count":39,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s481714","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T07:10:12Z","timestamp":1735283412000},"page":"6313-6329","source":"Crossref","is-referenced-by-count":22,"title":["Tomatidine Alleviates Intervertebral Disc Degeneration by Activating the Nrf2\/HO-1\/GPX4 Signaling Pathway"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Ze","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifeng","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghua","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0356-1834","authenticated-orcid":true,"given":"Weiwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/S0140-6736(21)00733-9","volume":"398","author":"Knezevic","year":"2021","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"799130","DOI":"10.3389\/fphar.2021.799130","volume":"12","author":"Zhang","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41584-021-00713-z","volume":"18","author":"Francisco","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1111\/os.13254","volume":"14","author":"Xin","year":"2022","journal-title":"Orthop Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.joca.2015.03.028","volume":"23","author":"Vergroesen","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1219840","DOI":"10.3389\/fcell.2023.1219840","volume":"11","author":"Fan","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3390\/cells11030394","volume":"11","author":"Ohnishi","year":"2022","journal-title":"Cells"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1049936","DOI":"10.3389\/fimmu.2022.1049936","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"972753","DOI":"10.3389\/fimmu.2022.972753","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"166961","DOI":"10.1016\/j.bbadis.2023.166961","volume":"1870","author":"Zhuang","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1007\/s10571-023-01388-8","volume":"43","author":"Gao","year":"2023","journal-title":"Cell Mol Neurobiol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12974-022-02400-6","volume":"19","author":"Dang","year":"2022","journal-title":"J Neuroinflammation"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"624529","DOI":"10.3389\/fphar.2020.624529","volume":"11","author":"Deng","year":"2020","journal-title":"Front Pharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"122109","DOI":"10.1016\/j.lfs.2023.122109","volume":"332","author":"Niu","year":"2023","journal-title":"Life Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"12525","DOI":"10.1021\/acs.jafc.2c05262","volume":"70","author":"Chen","year":"2022","journal-title":"J Agric Food Chem"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"111732","DOI":"10.1016\/j.intimp.2024.111732","volume":"130","author":"Abdulaal","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3389\/fimmu.2020.00285","volume":"11","author":"Yang","year":"2020","journal-title":"Front Immunol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1433113","DOI":"10.3389\/fimmu.2024.1433113","volume":"15","author":"Consonni","year":"2024","journal-title":"Front Immunol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"8061","DOI":"10.2147\/JIR.S490418","volume":"17","author":"Li","year":"2024","journal-title":"J Inflamm Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"108602","DOI":"10.1016\/j.jnutbio.2021.108602","volume":"91","author":"Wu","year":"2021","journal-title":"J Nutr Biochem"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"46208","DOI":"10.1038\/srep46208","volume":"7","author":"Fang","year":"2017","journal-title":"Sci Rep"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"12799","DOI":"10.18632\/aging.103222","volume":"12","author":"Chu","year":"2020","journal-title":"Aging"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1021\/jf204197r","volume":"60","author":"Fujiwara","year":"2012","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.923996","volume":"26","author":"Yu","year":"2020","journal-title":"Med Sci Monit"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.freeradbiomed.2022.08.018","volume":"190","author":"Wang","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"4482642","DOI":"10.1155\/2024\/4482642","volume":"2024","author":"Li","year":"2024","journal-title":"Mediators Inflamm 2024"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1080\/03008207.2022.2089565","volume":"63","author":"Zhang","year":"2022","journal-title":"Connect Tissue Res"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/s41419-024-07224-1","volume":"15","author":"Chen","year":"2024","journal-title":"Cell Death Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jor.23637","volume":"36","author":"Tam","year":"2017","journal-title":"J Orthop Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e70012","DOI":"10.1002\/jsp2.70012","volume":"7","author":"Zhao","year":"2024","journal-title":"JOR Spine"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.3390\/ijms21103601","volume":"21","author":"Cazzanelli","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.3390\/cells10092241","volume":"10","author":"Krut","year":"2021","journal-title":"Cells"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3390\/ijms24010208","volume":"24","author":"Mohd Isa","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"113434","DOI":"10.1016\/j.intimp.2024.113434","volume":"143","author":"Peng","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/nyas.13407","volume":"1401","author":"Marchev","year":"2017","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.3390\/molecules25225474","volume":"25","author":"Saha","year":"2020","journal-title":"Molecules"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.chembiol.2020.03.011","volume":"27","author":"Anandhan","year":"2020","journal-title":"Cell Chem. Biol."}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/98788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/98788","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T07:10:14Z","timestamp":1735283414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/tomatidine-alleviates-intervertebral-disc-degeneration-by-activating-t-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":39,"URL":"https:\/\/doi.org\/10.2147\/dddt.s481714","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]}}}