{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:57:32Z","timestamp":1754161052539,"version":"3.41.2"},"reference-count":41,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s492245","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T13:15:12Z","timestamp":1753708512000},"page":"6379-6389","source":"Crossref","is-referenced-by-count":0,"title":["Determining the 90% Effective Dose of Remimazolam to Prevent Physical Movement in Surgical Abortions: A Biased-Coin Up-and-Down Sequential Allocation Trial"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Fuquan","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8921-9145","authenticated-orcid":true,"given":"Pengfei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4484-5043","authenticated-orcid":true,"given":"Binwei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1877-9812","authenticated-orcid":true,"given":"Shengmei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-3369","authenticated-orcid":true,"given":"Xianhui","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.4274\/tjod.galenos.2024.88886","volume":"21","author":"Agaoglu","year":"2024","journal-title":"Turk J Obstet Gynecol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1016\/j.jfma.2018.12.012","volume":"118","author":"Yen","year":"2019","journal-title":"J Formos Med Assoc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"690875","DOI":"10.3389\/fphar.2021.690875","volume":"12","author":"Kilpatrick","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.gie.2018.04.2351","volume":"88","author":"Rex","year":"2018","journal-title":"Gastrointest Endosc"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1097\/EJA.0000000000001715","volume":"39","author":"Yao","year":"2022","journal-title":"Eur J Anaesthesiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.chest.2018.09.015","volume":"155","author":"Pastis","year":"2019","journal-title":"Chest"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12871-021-01373-y","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Anesthesiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/jcpt.13525","volume":"47","author":"Zhang","year":"2022","journal-title":"J Clin Pharm Ther"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s40122-023-00483-4","volume":"12","author":"Fan","year":"2023","journal-title":"Pain Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s12871-023-02164-3","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Anesthesiol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/00000542-199701000-00004","volume":"86","author":"Minto","year":"1997","journal-title":"Anesthesiology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1097\/ALN.0000000000003103","volume":"132","author":"Schuttler","year":"2020","journal-title":"Anesthesiology"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1213\/ANE.0000000000000548","volume":"120","author":"Borkett","year":"2015","journal-title":"Anesth Analg"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/pan.13088","volume":"27","author":"Gorges","year":"2017","journal-title":"Paediatr Anaesth"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/01.anes.0000267514.42592.2a","volume":"107","author":"Pace","year":"2007","journal-title":"Anesthesiology"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1186\/s12884-021-04229-y","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.7334\/psicothema2022.292","volume":"35","author":"Blanca","year":"2023","journal-title":"Psicothema"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.ogc.2010.05.006","volume":"37","author":"Munro","year":"2010","journal-title":"Obstet Gynecol Clin North Am"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.gie.2015.08.062","volume":"83","author":"Pambianco","year":"2016","journal-title":"Gastrointest Endosc"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"4101","DOI":"10.2147\/DDDT.S390403","volume":"16","author":"Zhang","year":"2022","journal-title":"Drug Des Devel Ther"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1080\/01621459.1948.10483254","volume":"43","author":"Dixon","year":"1948","journal-title":"J Am Stat Assoc"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1080\/01621459.1965.10480843","volume":"60","author":"Dixon","year":"1965","journal-title":"J Am Stat Assoc"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"745","DOI":"10.2307\/2533975","volume":"53","author":"Durham","year":"1997","journal-title":"Biometrics"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1080\/02664763.2011.573540","volume":"38","author":"Jia","year":"2011","journal-title":"J Appl Stat"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/s40265-021-01544-8","volume":"81","author":"Lee","year":"2021","journal-title":"Drugs"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1097\/01.anes.0000267503.85085.c0","volume":"107","author":"Kilpatrick","year":"2007","journal-title":"Anesthesiology"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.1111\/bcp.15839","volume":"89","author":"Ye","year":"2023","journal-title":"Br J Clin Pharmacol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1111\/cts.13572","volume":"16","author":"Yue","year":"2023","journal-title":"Clin Transl Sci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s44254-023-00021-7","volume":"1","author":"Sneyd","year":"2023","journal-title":"Anesthesiol Perioperative Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1007\/s00228-020-02984-z","volume":"76","author":"Pesic","year":"2020","journal-title":"Eur J Clin Pharmacol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.2147\/DDDT.S461122","volume":"18","author":"Cai","year":"2024","journal-title":"Drug Des Devel Ther"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1253738","DOI":"10.3389\/fmed.2023.1253738","volume":"10","author":"Long","year":"2023","journal-title":"Front Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1372139","DOI":"10.3389\/fphar.2024.1372139","volume":"15","author":"Ni","year":"2024","journal-title":"Front Pharmacol"},{"key":"ref34","first-page":"4594","volume":"12","author":"Chen","year":"2020","journal-title":"Am J Transl Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12871-022-01779-2","volume":"22","author":"Park","year":"2022","journal-title":"BMC Anesthesiol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.bja.2022.02.040","volume":"129","author":"Chae","year":"2022","journal-title":"Br J Anaesth"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11090833","volume":"11","author":"Ignaszak-Kaus","year":"2021","journal-title":"J Pers Med"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s12630-021-01974-8","volume":"68","author":"Darvall","year":"2021","journal-title":"Can J Anaesth"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e85","DOI":"10.1016\/j.bja.2022.06.028","volume":"129","author":"Wang","year":"2022","journal-title":"Br J Anaesth"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00540-022-03041-y","volume":"36","author":"Hari","year":"2022","journal-title":"J Anesth"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1001\/jama.1983.03330370053031","volume":"249","author":"Hanley","year":"1983","journal-title":"JAMA"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/105236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/105236","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T13:15:12Z","timestamp":1753708512000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/determining-the-90-effective-dose-of-remimazolam-to-prevent-physical-m-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":41,"URL":"https:\/\/doi.org\/10.2147\/dddt.s492245","relation":{},"ISSN":["1177-8881"],"issn-type":[{"type":"electronic","value":"1177-8881"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}