{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:53:03Z","timestamp":1787593983332,"version":"build-2736575974"},"reference-count":51,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s499284","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T12:02:37Z","timestamp":1742558557000},"page":"2157-2172","source":"Crossref","is-referenced-by-count":17,"title":["Caffeic Acid Protects Against Ulcerative Colitis via Inhibiting Mitochondrial Apoptosis and Immune Overactivation in Drosophila"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Minghui","family":"Xiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-0017","authenticated-orcid":true,"given":"Yongqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0397-3698","authenticated-orcid":true,"given":"Jianzheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1053\/j.gastro.2023.06.013","volume":"165","author":"Wattacheril","year":"2023","journal-title":"Gastroenterology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41575-020-00360-x","volume":"18","author":"Kaplan","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.3389\/fphar.2019.01281","volume":"10","author":"Lertnimitphun","year":"2019","journal-title":"Front Pharmacol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"115430","DOI":"10.1016\/j.biopha.2023.115430","volume":"167","author":"Sun","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.20805.1","volume":"9","author":"Porter","year":"2020","journal-title":"F1000Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1001\/jama.2021.11750","volume":"326","author":"Slomski","year":"2021","journal-title":"JAMA"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/jgh3.12216","volume":"3","author":"Roberts-Thomson","year":"2019","journal-title":"JGH Open"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.2147\/JIR.S353038","volume":"15","author":"Lu","year":"2022","journal-title":"J Inflamm Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.ebiom.2018.08.035","volume":"35","author":"Zhou","year":"2018","journal-title":"EBioMedicine"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ibmb.2019.03.003","volume":"108","author":"Kleino","year":"2019","journal-title":"Insect Biochem mol Biol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1142\/S0192415X22500756","volume":"50","author":"Zheng","year":"2022","journal-title":"Am J Chin Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.intimp.2015.09.029","volume":"29","author":"Jia","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e0163327","DOI":"10.1371\/journal.pone.0163327","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1007\/s10753-021-01449-4","volume":"44","author":"Yin","year":"2021","journal-title":"Inflammation"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"784211","DOI":"10.3389\/fmicb.2021.784211","volume":"12","author":"Wan","year":"2021","journal-title":"Front Microbiol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010588","volume":"24","author":"Pavlikova","year":"2022","journal-title":"Int J mol Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"7705","DOI":"10.1039\/d3fo02286b","volume":"14","author":"Wen","year":"2023","journal-title":"Food Funct"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"735483","DOI":"10.3389\/fcell.2021.735483","volume":"9","author":"Sheng","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"7684","DOI":"10.1021\/acs.jafc.9b02078","volume":"67","author":"Chang","year":"2019","journal-title":"J Agric Food Chem"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"4773","DOI":"10.1111\/febs.16067","volume":"289","author":"Guo","year":"2022","journal-title":"FEBS J"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1072715","DOI":"10.3389\/fphar.2022.1072715","volume":"13","author":"Xiu","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"893758","DOI":"10.3389\/fphar.2022.893758","volume":"13","author":"Yang","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1019594","DOI":"10.3389\/fphar.2022.1019594","volume":"13","author":"He","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"117578","DOI":"10.1016\/j.jep.2023.117578","volume":"322","author":"Li","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"114265","DOI":"10.1016\/j.biopha.2023.114265","volume":"159","author":"Han","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3791\/63141","author":"Abu","year":"2021","journal-title":"J Vis Exp"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"115906","DOI":"10.1016\/j.biopha.2023.115906","volume":"169","author":"He","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"113786","DOI":"10.1016\/j.jep.2021.113786","volume":"279","author":"Lee","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e23727","DOI":"10.1096\/fj.202400390R","volume":"38","author":"Dai","year":"2024","journal-title":"FASEB J"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"114208","DOI":"10.1016\/j.jep.2021.114208","volume":"276","author":"Song","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/0471142735.im1525s104","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr Protoc Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"21528","DOI":"10.1073\/pnas.1215849110","volume":"109","author":"Rera","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1038\/s41467-024-46956-8","volume":"15","author":"Guo","year":"2024","journal-title":"Nat Commun"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/bies.201200125","volume":"35","author":"Figge","year":"2013","journal-title":"Bioessays"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","volume":"380","author":"Ordas","year":"2012","journal-title":"Lancet"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020426","volume":"11","author":"Wei","year":"2022","journal-title":"Antioxidants"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"10877","DOI":"10.1021\/jf301807g","volume":"60","author":"El-Seedi","year":"2012","journal-title":"J Agric Food Chem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/j.1365-2982.2012.01921.x","volume":"24","author":"Camilleri","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.3748\/wjg.v29.i16.2380","volume":"29","author":"Zheng","year":"2023","journal-title":"World J Gastroenterol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5483\/bmbrep.2008.41.1.011","volume":"41","author":"Jeong","year":"2008","journal-title":"BMB Rep"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111338","volume":"22","author":"Andrieux","year":"2021","journal-title":"Int J mol Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1002\/jcp.25349","volume":"231","author":"Yang","year":"2016","journal-title":"J Cell Physiol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"C817","DOI":"10.1152\/ajpcell.00139.2004","volume":"287","author":"Brookes","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1083\/jcb.200211046","volume":"160","author":"Chen","year":"2003","journal-title":"J Cell Biol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"102304","DOI":"10.1016\/j.redox.2022.102304","volume":"52","author":"Jiang","year":"2022","journal-title":"Redox Biol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e2461","DOI":"10.7717\/peerj.2461","volume":"4","author":"M\u2019Angale","year":"2016","journal-title":"PeerJ"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"649","DOI":"10.4049\/jimmunol.1002302","volume":"186","author":"Valanne","year":"2011","journal-title":"J Immunol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.4049\/jimmunol.1303309","volume":"192","author":"Myllymaki","year":"2014","journal-title":"J Immunol"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20200986","volume":"40","author":"Yue","year":"2020","journal-title":"Biosci Rep"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s40168-022-01296-x","volume":"10","author":"Liu","year":"2022","journal-title":"Microbiome"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/101399","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/101399","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T12:02:40Z","timestamp":1742558560000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/caffeic-acid-protects-against-ulcerative-colitis-via-inhibiting-mitoch-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":51,"URL":"https:\/\/doi.org\/10.2147\/dddt.s499284","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}