{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:16:11Z","timestamp":1774858571573,"version":"3.50.1"},"reference-count":42,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s505541","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T06:35:11Z","timestamp":1741847711000},"page":"1909-1926","source":"Crossref","is-referenced-by-count":2,"title":["Design of a Highly Active Peptide Inhibitor of Farnesyltransferase and Its Protective Effect Against Acute Liver Failure"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6748-2867","authenticated-orcid":true,"given":"Chun-Lian","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang-Shuai","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A-Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9027-3028","authenticated-orcid":true,"given":"Chen-Qian","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Zhi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Zhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao-Hsin","family":"Tung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Sheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2025,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.14309\/ajg.0000000000002340","volume":"118","author":"Shingina","year":"2023","journal-title":"Am J Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1097\/MCC.0000000000000923","volume":"28","author":"Vasques","year":"2022","journal-title":"Curr Opin Crit Care"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0140-6736(95)90171-X","volume":"345","author":"Caraceni","year":"1995","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1055\/s-0038-1673372","volume":"39","author":"Rajaram","year":"2018","journal-title":"Semin Respir Crit Care Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1016\/j.jhep.2021.01.037","volume":"74","author":"Bernal","year":"2021","journal-title":"J Hepatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3724\/abbs.2023275","volume":"56","author":"Cheng","year":"2024","journal-title":"Acta Biochim Biophys Sin"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.ajem.2018.10.032","volume":"37","author":"Montrief","year":"2019","journal-title":"Am J Emerg Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/ncp.10459","volume":"35","author":"Dong","year":"2020","journal-title":"Nutr Clin Pract"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1159\/000444557","volume":"34","author":"Sowa","year":"2016","journal-title":"Dig Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3389\/fcimb.2020.00237","volume":"10","author":"Christgen","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"122158","DOI":"10.1016\/j.lfs.2023.122158","volume":"333","author":"Qi","year":"2023","journal-title":"Life Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"4641","DOI":"10.1016\/j.csbj.2021.07.038","volume":"19","author":"Wang","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"111612","DOI":"10.1016\/j.intimp.2024.111612","volume":"129","author":"Li","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s41420-024-02054-8","volume":"10","author":"Shi","year":"2024","journal-title":"Cell Death Discov"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1021\/cb500791f","volume":"10","author":"Palsuledesai","year":"2015","journal-title":"ACS Chem Biol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13024-022-00561-9","volume":"17","author":"Cuddy","year":"2022","journal-title":"Mol Neurodegener"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/pbc.22775","volume":"56","author":"Widemann","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1200\/JCO.2005.03.8638","volume":"24","author":"Widemann","year":"2006","journal-title":"J Clin Oncol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"8998","DOI":"10.1111\/jcmm.15533","volume":"24","author":"Ding","year":"2020","journal-title":"J Cell Mol Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1021\/jm960602m","volume":"40","author":"Leonard","year":"1997","journal-title":"J Med Chem"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1002\/jccs.202100037","volume":"68","author":"Yang","year":"2021","journal-title":"J Chin Chem Soc"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12929-021-00762-2","volume":"28","author":"Liu","year":"2021","journal-title":"J Biomed Sci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e12829","DOI":"10.1111\/cpr.12829","volume":"53","author":"Wang","year":"2020","journal-title":"Cell Prolif"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"100352","DOI":"10.1016\/j.jhepr.2021.100352","volume":"3","author":"Claeys","year":"2021","journal-title":"JHEP Reports"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1038\/s41591-020-1102-2","volume":"26","author":"Kolodziejczyk","year":"2020","journal-title":"Nature Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1478-3231.2009.02181.x","volume":"30","author":"Yoon","year":"2010","journal-title":"Liver Int"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1053\/jhep.2000.20239","volume":"32","author":"Nagaki","year":"2000","journal-title":"Hepatology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1097\/SHK.0000000000000239","volume":"42","author":"Shirozu","year":"2014","journal-title":"Shock Augusta ga"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ejphar.2014.05.024","volume":"738","author":"Kim","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"G1069","DOI":"10.1152\/ajpgi.90689.2008","volume":"296","author":"Kuhla","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"6403","DOI":"10.1073\/pnas.89.14.6403","volume":"89","author":"Kato","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref32","first-page":"1615","volume":"63","author":"P\u00e9rez de Castro","year":"2003","journal-title":"Cancer Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1124\/jpet.111.183558","volume":"339","author":"Yang","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.3390\/cells11121885","volume":"11","author":"Rajesh","year":"2022","journal-title":"Cells"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"102348","DOI":"10.1016\/j.coi.2023.102348","volume":"83","author":"Karki","year":"2023","journal-title":"Curr Opin Immunol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/imr.12909","volume":"297","author":"Zheng","year":"2020","journal-title":"Immunol Rev"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1038\/s41423-023-01107-9","volume":"20","author":"Oh","year":"2023","journal-title":"Cell mol Immunol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature13683","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1279264","DOI":"10.3389\/fimmu.2023.1279264","volume":"14","author":"Xie","year":"2023","journal-title":"Front Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ceb.2020.02.004","volume":"63","author":"Schwarzer","year":"2020","journal-title":"Curr Opin Cell Biol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41586-019-1830-y","volume":"577","author":"Tao","year":"2020","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"406","DOI":"10.3389\/fcimb.2019.00406","volume":"9","author":"Malireddi","year":"2019","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/101092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/101092","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T06:35:13Z","timestamp":1741847713000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/design-of-a-highly-active-peptide-inhibitor-of-farnesyltransferase-and-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":42,"URL":"https:\/\/doi.org\/10.2147\/dddt.s505541","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}