{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:14:26Z","timestamp":1791231266891,"version":"4.1.0"},"reference-count":27,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s509036","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T10:20:52Z","timestamp":1748341252000},"page":"4457-4479","source":"Crossref","is-referenced-by-count":2,"title":["Design and Synthesis of Novel 5,6,7,8-Tetrahydropyrido[2,3-D]pyrimidine Derivatives as VCP\/p97 Inhibitors for the Treatment of Acute Myeloid Leukemia (AML)"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Xueyuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zebo","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1016\/S0140-6736(18)31694-5","volume":"392","author":"Foreman","year":"2018","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/S0140-6736(12)60485-1","volume":"379","author":"Castaigne","year":"2012","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1182\/blood-2020-141987","volume":"136","author":"Riva","year":"2020","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1056\/NEJMoa1614359","volume":"377","author":"Stone","year":"2017","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1056\/NEJMoa1716984","volume":"378","author":"Dinardo","year":"2018","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"111232","DOI":"10.1016\/j.intimp.2023.111232","volume":"127","author":"Yu","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41375-018-0312-9","volume":"33","author":"Cortes","year":"2018","journal-title":"Leukemia"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1182\/blood.2020004856","volume":"135","author":"Panayiotidis","year":"2020","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1056\/NEJMoa1902688","volume":"381","author":"Perl","year":"2019","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","volume":"374","author":"Papaemmanuil","year":"2016","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1182\/blood-2016-08-733196","volume":"129","author":"D\u00f6hner","year":"2017","journal-title":"Blood"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1002\/ajh.25975","volume":"95","author":"Estey","year":"2020","journal-title":"Am J Hematol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev.biochem.67.1.425","volume":"67","author":"Hershko","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.bbamcr.2013.02.028","volume":"1843","author":"Bassermann","year":"2014","journal-title":"Biochimica Et Biophysica Acta"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/ni0102-20","volume":"3","author":"Yinon","year":"2002","journal-title":"Nat Immunol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"100663","DOI":"10.1016\/j.drup.2019.100663","volume":"48","author":"Narayanan","year":"2020","journal-title":"Drug Resist Updates"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1152\/physrev.00027.2001","volume":"82","author":"Glickman","year":"2002","journal-title":"Physiol Rev"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1158\/1078-0432.CCR-15-0481","volume":"22","author":"Andreeff","year":"2016","journal-title":"Clin Cancer Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1111\/bjh.13323","volume":"169","author":"Swords","year":"2015","journal-title":"Br J Haematol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.bbamcr.2013.03.031","volume":"1843","author":"Franz","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.tibs.2011.06.001","volume":"36","author":"Stolz","year":"2011","journal-title":"Trends Biochem Sci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.semcdb.2007.09.008","volume":"18","author":"Raasi","year":"2007","journal-title":"Semin Cell Dev Biol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.bbamcr.2011.09.002","volume":"1823","author":"Wolf","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1126\/scitranslmed.abg1168","volume":"13","author":"Roux","year":"2021","journal-title":"Sci, trans med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e0266478","DOI":"10.1371\/journal.pone.0266478","volume":"17","author":"Gopalakrishnapillai","year":"2022","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1124\/jpet.120.000486","volume":"378","author":"Leinonen","year":"2021","journal-title":"J Pharmacol Exp Ther"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"117050","DOI":"10.1016\/j.bmc.2022.117050","volume":"74","author":"Wang","year":"2022","journal-title":"Bioorg Med Chem"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/103342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/103342","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T10:20:52Z","timestamp":1748341252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/design-and-synthesis-of-novel-5678-tetrahydropyrido23-dpyrimidine-deri-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":27,"URL":"https:\/\/doi.org\/10.2147\/dddt.s509036","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}