{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:14:48Z","timestamp":1790957688801,"version":"4.1.0"},"reference-count":93,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s515930","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T14:20:14Z","timestamp":1748874014000},"page":"4689-4715","source":"Crossref","is-referenced-by-count":12,"title":["Lobetyolin Suppressed Osteoclastogenesis and Alleviated Bone Loss in Ovariectomy-Induced Osteoporosis via Hindering p50\/p65 Nuclear Translocation and Downstream NFATc1\/c-Fos Expression"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Chunmei","family":"Xiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiting","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-4987","authenticated-orcid":true,"given":"Dun","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0515-9841","authenticated-orcid":true,"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"14583","DOI":"10.3390\/ijms241914583","volume":"24","author":"Adejuyigbe","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/s41574-023-00866-9","volume":"19","author":"Foessl","year":"2023","journal-title":"Nat Rev Endocrinol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-23-0116","volume":"259","author":"Lu","year":"2023","journal-title":"J Endocrinol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s12672-024-01020-1","volume":"15","author":"Xie","year":"2024","journal-title":"Discov Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3390\/biom9060223","volume":"9","author":"Suzuki","year":"2019","journal-title":"Biomolecules"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.eprac.2024.01.014","volume":"30","author":"Cosman","year":"2024","journal-title":"Endocr Pract"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1097\/GRF.0000000000000572","volume":"63","author":"Mu\u00f1oz","year":"2020","journal-title":"Clin Obstet Gynecol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1186\/s12967-023-04563-z","volume":"21","author":"Wu","year":"2023","journal-title":"J Transl Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jot.2023.06.002","volume":"42","author":"Ma","year":"2023","journal-title":"J Orthop Transl"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/jbmr.4485","volume":"37","author":"Zhang","year":"2022","journal-title":"J Bone Miner Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"6638","DOI":"10.7150\/thno.44793","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"7067","DOI":"10.1002\/jcp.26508","volume":"233","author":"Zhang","year":"2018","journal-title":"J Cell Physiol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3390\/nu11020297","volume":"11","author":"Tousen","year":"2019","journal-title":"Nutrients"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"20753","DOI":"10.18632\/aging.104008","volume":"12","author":"Piao","year":"2020","journal-title":"Aging"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/ajh.21170","volume":"83","author":"Poulsen","year":"2008","journal-title":"Am J Hematol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.apsb.2019.11.004","volume":"10","author":"Son","year":"2020","journal-title":"Acta Pharmaceutica Sinica B"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"110954","DOI":"10.1016\/j.intimp.2023.110954","volume":"124","author":"Qiao","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"155262","DOI":"10.1016\/j.phymed.2023.155262","volume":"123","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"115895","DOI":"10.1016\/j.bcp.2023.115895","volume":"218","author":"Feng","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1007\/s11011-023-01292-6","volume":"38","author":"Wang","year":"2023","journal-title":"Metab Brain Dis"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1405163","DOI":"10.3389\/fphar.2024.1405163","volume":"15","author":"Chen","year":"2024","journal-title":"Front Pharmacol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1058780","DOI":"10.3389\/fnagi.2022.1058780","volume":"14","author":"Ma","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"115876","DOI":"10.1016\/j.jep.2022.115876","volume":"302","author":"Shang","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1013248","DOI":"10.3389\/fimmu.2022.1013248","volume":"13","author":"Tang","year":"2022","journal-title":"Front Immunol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1038\/s41598-017-03024-0","volume":"7","author":"Xiong","year":"2017","journal-title":"Sci Rep"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1021\/np5007179","volume":"78","author":"Nguyen","year":"2015","journal-title":"J Natural Prod"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1080\/14786419.2019.1622108","volume":"35","author":"Yoon","year":"2021","journal-title":"Nat Prod Res"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"154807","DOI":"10.1016\/j.phymed.2023.154807","volume":"115","author":"Ni","year":"2023","journal-title":"Phytomedicine"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1111\/jcmm.15009","volume":"24","author":"He","year":"2020","journal-title":"J Cell Mol Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jot.2020.03.001","volume":"26","author":"Yang","year":"2021","journal-title":"J Orthop Transl"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"112382","DOI":"10.1016\/j.mce.2024.112382","volume":"594","author":"Cai","year":"2024","journal-title":"Mol Cell Endocrinol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1111\/febs.13627","volume":"283","author":"Cartwright","year":"2016","journal-title":"FEBS J"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s00223-007-9092-3","volume":"82","author":"Balla","year":"2008","journal-title":"Calcif Tissue Int"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.clim.2009.01.004","volume":"131","author":"Balla","year":"2009","journal-title":"Clin Immunol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1002\/jbmr.1866","volume":"28","author":"Nakamura","year":"2013","journal-title":"J Bone Miner Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"6087","DOI":"10.1007\/s00018-021-03875-x","volume":"78","author":"Dufran\u00e7ais","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1111\/jcmm.15052","volume":"24","author":"Kong","year":"2020","journal-title":"J Cell Mol Med"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"101842","DOI":"10.1016\/j.arr.2023.101842","volume":"85","author":"Chen","year":"2023","journal-title":"Ageing Res Rev"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1002\/med.22081","volume":"45","author":"Yao","year":"2024","journal-title":"Med Res Rev"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"120847","DOI":"10.1016\/j.lfs.2022.120847","volume":"306","author":"Livshits","year":"2022","journal-title":"Life Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"114834","DOI":"10.1016\/j.biopha.2023.114834","volume":"163","author":"Zhang","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"ACOG Committee on Clinical Practice Guidelines\u2013Gynecology. Management of postmenopausal osteoporosis: ACOG Clinical Practice Guideline No. 2. Obstetrics Gynecol. 2022;139(4):698\u2013717. doi:10.1097\/AOG.0000000000004730","DOI":"10.1097\/AOG.0000000000004730"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"118899","DOI":"10.1016\/j.jep.2024.118899","volume":"337","author":"Mu","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1080\/10408347.2023.2242953","volume":"54","author":"Yue","year":"2024","journal-title":"Crit Rev Anal Chem"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s13659-020-00283-9","volume":"11","author":"Bailly","year":"2021","journal-title":"Nat Prod Bioprospecting"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1177\/09603271211021476","volume":"40","author":"Chen","year":"2021","journal-title":"Hum Exp Toxicol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"117106","DOI":"10.1016\/j.jep.2023.117106","volume":"319","author":"Xie","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s10616-023-00588-w","volume":"75","author":"Cheng","year":"2023","journal-title":"Cytotechnology"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jep.2015.03.027","volume":"166","author":"Chen","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"154071","DOI":"10.1016\/j.phymed.2022.154071","volume":"100","author":"Chen","year":"2022","journal-title":"Phytomedicine"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"870183","DOI":"10.3389\/fimmu.2022.870183","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"133440","DOI":"10.1016\/j.ijbiomac.2024.133440","volume":"277","author":"Zhao","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s11418-023-01714-w","volume":"77","author":"Hou","year":"2023","journal-title":"J Nat Med"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1248\/bpb.b24-00307","volume":"47","author":"Hu","year":"2024","journal-title":"Biol Pharm Bull"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.jep.2016.09.039","volume":"192","author":"Lu","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"101503","DOI":"10.1016\/j.xcrm.2024.101503","volume":"5","author":"Nurmi","year":"2024","journal-title":"Cell Rep Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1182\/blood-2017-01-761130","volume":"130","author":"Chen","year":"2017","journal-title":"Blood"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/cr.2010.159","volume":"21","author":"Novack","year":"2011","journal-title":"Cell Res"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harbor Perspect Biol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1476030","DOI":"10.3389\/fimmu.2024.1476030","volume":"15","author":"Cao","year":"2024","journal-title":"Front Immunol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"16175","DOI":"10.3390\/ijms242216175","volume":"24","author":"Jiang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3390\/cells11010132","volume":"11","author":"Yao","year":"2021","journal-title":"Cells"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e10539","DOI":"10.1002\/jbm4.10539","volume":"5","author":"McDonald","year":"2021","journal-title":"JBMR plus"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2008.10.146","volume":"378","author":"Soysa","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"102741","DOI":"10.1016\/j.autrev.2020.102741","volume":"20","author":"Ilchovska","year":"2021","journal-title":"Autoimmunity Rev"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"716469","DOI":"10.3389\/fimmu.2021.716469","volume":"12","author":"Barnabei","year":"2021","journal-title":"Front Immunol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1146\/annurev-biophys-083012-130338","volume":"42","author":"Napetschnig","year":"2013","journal-title":"Annu Rev Biophys"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1600-065X.2012.01099.x","volume":"246","author":"DiDonato","year":"2012","journal-title":"Immunol Rev"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s13075-017-1296-y","volume":"19","author":"Saito","year":"2017","journal-title":"Arthritis Res Therapy"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/B978-0-12-385940-2.00004-8","volume":"96","author":"Peterson","year":"2011","journal-title":"Curr Top Dev Biol"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/wsbm.1331","volume":"8","author":"Mitchell","year":"2016","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1007\/s00198-013-2313-x","volume":"24","author":"Abu-Amer","year":"2013","journal-title":"Osteoporosis Int"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/bs.ircmb.2016.04.003","volume":"326","author":"Osorio","year":"2016","journal-title":"Int Rev Cell Mol Biol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"pe5","DOI":"10.1126\/scisignal.2005108","volume":"7","author":"Tkach","year":"2014","journal-title":"Sci Signaling"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/sj.cdd.4401841","volume":"13","author":"Courtois","year":"2006","journal-title":"Cell Death Differ"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ejphar.2015.03.028","volume":"759","author":"Komori","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1080\/25785826.2023.2220931","volume":"47","author":"Yokota","year":"2024","journal-title":"Immunol Med"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.3390\/ijms20143576","volume":"20","author":"Agidigbi","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cytogfr.2020.02.003","volume":"52","author":"Li","year":"2020","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s11658-023-00501-5","volume":"28","author":"He","year":"2023","journal-title":"Cell Mol Biol Lett"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.2147\/JIR.S423819","volume":"16","author":"Hu","year":"2023","journal-title":"J Inflamm Res"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"9031","DOI":"10.1007\/s12274-024-6980-z","volume":"17","author":"Mamidi","year":"2024","journal-title":"Nano Res"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-024-02453-3","author":"Madan","year":"2024","journal-title":"Nature Biotechnol"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"1177271919843825","DOI":"10.1177\/1177271919843825","volume":"14","author":"Azizieh","year":"2019","journal-title":"Biomarker Insights"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.3390\/ijms23031376","volume":"23","author":"Cheng","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"154509","DOI":"10.1016\/j.phymed.2022.154509","volume":"108","author":"Ni","year":"2023","journal-title":"Phytomedicine"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"R837","DOI":"10.1186\/ar1753","volume":"7","author":"Jochems","year":"2005","journal-title":"Arthritis Res Therapy"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"e13726","DOI":"10.1111\/acel.13726","volume":"21","author":"Ali","year":"2022","journal-title":"Aging Cell"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.semcdb.2021.05.014","volume":"123","author":"Fischer","year":"2022","journal-title":"Semin Cell Dev Biol"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/s11914-009-0023-2","volume":"7","author":"McLean","year":"2009","journal-title":"Curr Osteoporosis Rep"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1590\/S0004-27302010000200007","volume":"54","author":"Lacativa","year":"2010","journal-title":"Arquivos brasileiros de endocrinologia e metabologia"},{"key":"ref93","first-page":"391","volume":"66","author":"Brincat","year":"2014","journal-title":"Minerva Ginecologica"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/103524","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/103524","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T14:20:16Z","timestamp":1748874016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/lobetyolin-suppressed-osteoclastogenesis-and-alleviated-bone-loss-in-o-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":93,"URL":"https:\/\/doi.org\/10.2147\/dddt.s515930","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}