{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:33:59Z","timestamp":1780551239232,"version":"3.54.1"},"reference-count":46,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s530516","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:40:12Z","timestamp":1757745612000},"page":"8213-8236","source":"Crossref","is-referenced-by-count":4,"title":["Elucidating the Pharmacological Basis of Xianling Cifang Granules Against Breast Cancer. A Metabolomic Profiling Study"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5495-7462","authenticated-orcid":true,"given":"Yang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"a041326","DOI":"10.1101\/cshperspect.a041326","volume":"13","author":"Nolan","year":"2023","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1001\/jama.2024.5534","volume":"331","author":"Nicholson","year":"2024","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1056\/NEJMoa1814017","volume":"380","author":"von Minckwitz","year":"2019","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"140071","DOI":"10.1016\/j.ijbiomac.2025.140071","volume":"298","author":"Liu","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1534735419876341","DOI":"10.1177\/1534735419876341","volume":"18","author":"Ye","year":"2019","journal-title":"Integr Cancer Ther"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"5249","DOI":"10.1038\/s41598-019-41243-9","volume":"9","author":"Xie","year":"2019","journal-title":"Sci Rep"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/bs.acr.2016.08.003","volume":"133","author":"Evans-Knowell","year":"2017","journal-title":"Adv Cancer Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1126\/science.1203543","volume":"331","author":"Chaffer","year":"2011","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1159\/000464115","volume":"41","author":"Xiao","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"6944","DOI":"10.3390\/molecules27206944","volume":"27","author":"Li","year":"2022","journal-title":"Molecules"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"133676","DOI":"10.1016\/j.foodchem.2022.133676","volume":"396","author":"Wang","year":"2022","journal-title":"Food Chem"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e37169","DOI":"10.1016\/j.heliyon.2024.e37169","volume":"10","author":"Guo","year":"2024","journal-title":"Heliyon"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.3390\/molecules28052101","volume":"28","author":"Al-Saeedi","year":"2023","journal-title":"Molecules"},{"key":"ref14","first-page":"715","volume":"32","author":"Wang","year":"2007","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.3390\/plants12081591","volume":"12","author":"Petrova","year":"2023","journal-title":"Plants"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3788","DOI":"10.3390\/ijms24043788","volume":"24","author":"Stary","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1515\/znc-2006-11-1217","volume":"61","author":"De-Simone","year":"2006","journal-title":"Z Naturforsch C J Biosci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"4242","DOI":"10.1111\/cas.14648","volume":"111","author":"Song","year":"2020","journal-title":"Cancer Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"121612","DOI":"10.1016\/j.biortech.2019.121612","volume":"289","author":"Lyu","year":"2019","journal-title":"Bioresour Technol"},{"key":"ref20","first-page":"785","volume":"25","author":"Zhang","year":"2020","journal-title":"J BUON"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"335","DOI":"10.2174\/1871527320666210827114227","volume":"21","author":"Borah","year":"2022","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1177\/1091581813504595","volume":"32","author":"Pimkaew","year":"2013","journal-title":"Int J Toxicol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3390\/biom10050799","volume":"10","author":"Pintatum","year":"2020","journal-title":"Biomolecules"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S1875-5364(21)60028-6","volume":"19","author":"Liu","year":"2021","journal-title":"Chin J Nat Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jpba.2017.04.012","volume":"141","author":"Xu","year":"2017","journal-title":"J Pharm Biomed Anal"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1142\/S0192415X11009470","volume":"39","author":"Wang","year":"2011","journal-title":"Am J Chin Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.chroma.2013.02.053","volume":"1286","author":"Wan","year":"2013","journal-title":"J Chromatogr A"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"155180","DOI":"10.1016\/j.phymed.2023.155180","volume":"123","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1055\/s-2006-960201","volume":"57","author":"Kawata","year":"1991","journal-title":"Planta Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"114624","DOI":"10.1016\/j.taap.2019.114624","volume":"377","author":"Li","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"101952","DOI":"10.18632\/oncotarget.21882","volume":"8","author":"Kim","year":"2017","journal-title":"Oncotarget"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"835485","DOI":"10.1155\/2014\/835485","volume":"2014","author":"Shenvi","year":"2014","journal-title":"Int J Med Chem"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.1021\/jm00075a018","volume":"36","author":"Johnson","year":"1993","journal-title":"J Med Chem"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1002\/cbic.201100053","volume":"12","author":"Opitz","year":"2011","journal-title":"Chembiochem"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"29749","DOI":"10.1039\/D3RA05799B","volume":"13","author":"El-Sayed Ebead","year":"2023","journal-title":"RSC Adv"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1145279","DOI":"10.3389\/fmolb.2023.1145279","volume":"10","author":"Di Benedetto","year":"2023","journal-title":"Front Mol Biosci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"965429","DOI":"10.3389\/fmed.2022.965429","volume":"9","author":"Shropshire","year":"2022","journal-title":"Front Med Lausanne"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3322\/caac.21320","volume":"66","author":"DeSantis","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"S56","DOI":"10.1016\/S0960-9776(11)70295-8","volume":"20 Suppl 3","author":"Kerbel","year":"2011","journal-title":"Breast"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"111883","DOI":"10.1016\/j.biopha.2021.111883","volume":"141","author":"Yang","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"6125","DOI":"10.2174\/1381612811319340006","volume":"19","author":"Takemura","year":"2013","journal-title":"Curr Pharm Des"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3390\/nu12030761","volume":"12","author":"Selvakumar","year":"2020","journal-title":"Nutrients"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s13205-014-0220-2","volume":"5","author":"Singh","year":"2015","journal-title":"3 Biotech"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.jconrel.2022.07.031","volume":"349","author":"Burnouf","year":"2022","journal-title":"J Control Release"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1038\/s41588-022-01212-x","volume":"54","author":"Liu","year":"2022","journal-title":"Nat Genet"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1038\/s41419-021-04338-8","volume":"12","author":"Lin","year":"2021","journal-title":"Cell Death Dis"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/106938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/106938","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T06:40:12Z","timestamp":1757745612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/elucidating-the-pharmacological-basis-of-xianling-cifang-granules-agai-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":46,"URL":"https:\/\/doi.org\/10.2147\/dddt.s530516","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]}}}