{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:44:10Z","timestamp":1789177450576,"version":"build-2803163510"},"reference-count":41,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s537699","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T02:30:12Z","timestamp":1768185012000},"page":"1-13","source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous Determination of Venetoclax and Posaconazole in Human Plasma by UPLC-MS\/MS: Application to Therapeutic Drug Monitoring in Acute Myeloid Leukemia Patients"],"prefix":"10.2147","volume":"Volume 20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5017-5515","authenticated-orcid":true,"given":"Xiaohai","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5046-9806","authenticated-orcid":true,"given":"Ruanjuan","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Ai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000536152","volume":"147","author":"Wachter","year":"2024","journal-title":"Acta Haematol"},{"key":"ref3","first-page":"38","volume":"103","author":"Pelcovits","year":"2020","journal-title":"R I Med J"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1200\/JCO.2016.71.2208","volume":"35","author":"Bullinger","year":"2017","journal-title":"J Clin Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/s41591-018-0081-z","volume":"24","author":"Desai","year":"2018","journal-title":"Nat Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1111\/bjh.14823","volume":"179","author":"Medinger","year":"2017","journal-title":"Br J Haematol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1182\/blood-2015-01-621664","volume":"126","author":"Dombret","year":"2015","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1200\/JCO.2011.38.9429","volume":"30","author":"Kantarjian","year":"2012","journal-title":"J Clin Oncol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1471-2407-14-69","volume":"14","author":"Mayer","year":"2014","journal-title":"BMC Cancer"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41580-023-00629-4","volume":"24","author":"Czabotar","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm3722","volume":"15","author":"Czabotar","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1089\/ars.2005.7.508","volume":"7","author":"Kowaltowski","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.stem.2012.12.013","volume":"12","author":"Lagadinou","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1007\/s40265-016-0596-x","volume":"76","author":"Deeks","year":"2016","journal-title":"Drugs"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1080\/13543784.2023.2193679","volume":"32","author":"Bruzzese","year":"2023","journal-title":"Expert Opin Investig Drugs"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1182\/blood-2018-08-868752","volume":"133","author":"DiNardo","year":"2019","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1080\/10428194.2022.2060504","volume":"63","author":"Miranti","year":"2022","journal-title":"Leuk Lymphoma"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jinf.2023.05.005","volume":"87","author":"Puerta-Alcalde","year":"2023","journal-title":"J Infect"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1177\/10781552231175825","volume":"30","author":"White","year":"2024","journal-title":"J Oncol Pharm Pract"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1056\/NEJMoa061094","volume":"356","author":"Cornely","year":"2007","journal-title":"N Engl J Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0140-6736(21)00219-1","volume":"397","author":"Maertens","year":"2021","journal-title":"Lancet"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"379","DOI":"10.2165\/11319340-000000000-00000","volume":"49","author":"Li","year":"2010","journal-title":"Clin Pharmacokinet"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1517\/17425255.2012.639360","volume":"8","author":"Krishna","year":"2012","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.3390\/pharmaceutics15061680","volume":"15","author":"De Gregori","year":"2023","journal-title":"Pharmaceutics"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2174\/0115748928330206241104161111","volume":"21","author":"Guo","year":"2025","journal-title":"Recent Pat Anticancer Drug Discov"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4155\/bio-2021-0207","volume":"14","author":"Reddy","year":"2022","journal-title":"Bioanalysis"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e70179","DOI":"10.1002\/bmc.70179","volume":"39","author":"Westra","year":"2025","journal-title":"Biomed Chromatogr"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"107565","DOI":"10.1016\/j.vascn.2024.107565","volume":"130","author":"Xia","year":"2024","journal-title":"J Pharmacol Toxicol Methods"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1002\/cptx.47","volume":"76","author":"Smith","year":"2018","journal-title":"Curr Protoc Toxicol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1373\/jalm.2016.022756","volume":"1","author":"Xiao","year":"2017","journal-title":"J Appl Lab Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"259","DOI":"10.4155\/bio-2024-0013","volume":"16","author":"Timmerman","year":"2024","journal-title":"Bioanalysis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.3390\/molecules27051607","volume":"27","author":"Yang","year":"2022","journal-title":"Molecules"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e5738","DOI":"10.1002\/bmc.5738","volume":"37","author":"Yang","year":"2023","journal-title":"Biomed Chromatogr"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"101693","DOI":"10.1016\/j.jsps.2023.06.026","volume":"31","author":"Alnasser","year":"2023","journal-title":"Saudi Pharm J"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00280-020-04179-w","volume":"87","author":"Bhatnagar","year":"2021","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.clinthera.2017.01.003","volume":"39","author":"Agarwal","year":"2017","journal-title":"Clin Ther"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.1182\/bloodadvances.2019000930","volume":"3","author":"Aldoss","year":"2019","journal-title":"Blood Adv"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2040620720966882","DOI":"10.1177\/2040620720966882","volume":"11","author":"Kang","year":"2020","journal-title":"Ther Adv Hematol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.1200\/JCO.2010.30.2307","volume":"28","author":"Ramalingam","year":"2010","journal-title":"J Clin Oncol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"ref41","unstructured":"National Cancer Institute (2017) Common terminology criteria for adverse events version 5.0. 2017. Available from: https:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_5x7.pdf. Accessed December 30, 2025."}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/110883","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/110883","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T02:30:13Z","timestamp":1768185013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/simultaneous-determination-of-venetoclax-and-posaconazole-in-human-pla-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":41,"URL":"https:\/\/doi.org\/10.2147\/dddt.s537699","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}