{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:43:27Z","timestamp":1788623007358,"version":"build-2803163510"},"reference-count":80,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s558221","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T08:20:14Z","timestamp":1763972414000},"page":"10473-10483","source":"Crossref","is-referenced-by-count":2,"title":["Targeting THR-\u03b2 for MASLD: Mechanisms and Drug Development"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3724-2196","authenticated-orcid":true,"given":"Yunlong","family":"Hua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianjun","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2155-8110","authenticated-orcid":true,"given":"Haiyan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1002\/hep.31150","volume":"71","author":"Zhou","year":"2020","journal-title":"Hepatology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/s41587-023-01787-8","volume":"41","author":"Dolgin","year":"2023","journal-title":"Nat Biotechnol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref5","unstructured":"National Workshop on Fatty Liver and Alcoholic Liver Disease CSOH. Guideline of prevention and treatment for nonalcoholic fatty liver disease: a 2018 update. J Pract Hepatol. 2018;21:177\u2013186."},{"key":"ref6","first-page":"594","volume":"19","author":"Ying","year":"2013","journal-title":"Med Recapitulate"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1002\/hep.31518","volume":"73","author":"Tilg","year":"2021","journal-title":"Hepatology"},{"key":"ref8","first-page":"374","volume":"27","author":"Hanhui","year":"2024","journal-title":"Pract Pharm Clin Remedies"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"6839","DOI":"10.3390\/ijms25136839","volume":"25","author":"Longo","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref10","volume-title":"Physiology","year":"2018"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41575-024-00991-4","volume":"22","author":"Sinha","year":"2024","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"807","DOI":"10.3760\/cma.j.cn501113-20190520-00178","volume":"29","author":"Beiyu","year":"2021","journal-title":"Chin J Hepatol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41574-019-0218-2","volume":"15","author":"Luongo","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1210\/edrv.23.1.0455","volume":"23","author":"Bianco","year":"2002","journal-title":"Endocr Rev"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s40618-020-01208-6","volume":"43","author":"Piantanida","year":"2020","journal-title":"J Endocrinol Invest"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.3390\/cells12071022","volume":"12","author":"Marschner","year":"2023","journal-title":"Cells"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.freeradbiomed.2022.01.024","volume":"181","author":"Tawfik","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.tem.2022.08.001","volume":"33","author":"Hatziagelaki","year":"2022","journal-title":"Trends Endocrinol Metab"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1038\/nrd1551","volume":"3","author":"Gronemeyer","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1136\/gutjnl-2023-331741","volume":"73","author":"Dubois","year":"2024","journal-title":"Gut"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1080\/03007995.2017.1330259","volume":"33","author":"Delitala","year":"2017","journal-title":"Curr Med Res Opin"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0083-6729(05)70005-4","volume":"70","author":"Friesema","year":"2005","journal-title":"Vitam Horm"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1152\/physrev.2001.81.3.1097","volume":"81","author":"Yen","year":"2001","journal-title":"Physiol Rev"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1530\/EC-18-0499","volume":"7","author":"Krause","year":"2018","journal-title":"Endocr Connect"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1023\/A:1010052101214","volume":"1","author":"Cheng","year":"2000","journal-title":"Rev Endocr Metab Disord"},{"key":"ref26","first-page":"2","volume":"22","author":"Xu","year":"2001","journal-title":"Acad J Second Mil Med Univ"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3713","DOI":"10.1210\/en.2013-2058","volume":"155","author":"Martin","year":"2014","journal-title":"Endocrinology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1055\/a-1088-1187","volume":"128","author":"H\u00f6nes","year":"2020","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3389\/fendo.2018.00511","volume":"9","author":"Duntas","year":"2018","journal-title":"Front Endocrinol"},{"key":"ref30","first-page":"18","volume":"13","author":"Al Doghaither","year":"2019","journal-title":"Int J Health Sci"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.tem.2014.07.001","volume":"25","author":"Sinha","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1089\/thy.2018.0257","volume":"28","author":"Mantovani","year":"2018","journal-title":"Thyroid"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12929-019-0517-x","volume":"26","author":"Chi","year":"2019","journal-title":"J Biomed Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"15145","DOI":"10.1038\/s41598-018-32245-0","volume":"8","author":"Lee","year":"2018","journal-title":"Sci Rep"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.dld.2022.06.021","volume":"55","author":"Li","year":"2023","journal-title":"Dig Liver Dis"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jhep.2012.02.027","volume":"57","author":"Chung","year":"2012","journal-title":"J Hepatol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1089\/thy.2020.0651","volume":"31","author":"Chaves","year":"2021","journal-title":"Thyroid"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1210\/me.2008-0311","volume":"23","author":"Araki","year":"2009","journal-title":"Mol Endocrinol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"13899","DOI":"10.1074\/jbc.270.23.13899","volume":"270","author":"Cohen","year":"1995","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/0092-8674(91)90020-Y","volume":"65","author":"Umesono","year":"1991","journal-title":"Cell"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"4292","DOI":"10.1210\/en.2006-0116","volume":"147","author":"Hashimoto","year":"2006","journal-title":"Endocrinology"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"7964","DOI":"10.1074\/jbc.M211062200","volume":"278","author":"Jackson-Hayes","year":"2003","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.plipres.2012.11.002","volume":"52","author":"Musso","year":"2013","journal-title":"Prog Lipid Res"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-016-0113-7","volume":"6","author":"Sinha","year":"2016","journal-title":"Cell Biosci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1194\/jlr.M051664","volume":"55","author":"Bonde","year":"2014","journal-title":"J Lipid Res"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"14078","DOI":"10.1074\/jbc.C110.107375","volume":"285","author":"Adams","year":"2010","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1210\/mend.14.7.0470","volume":"14","author":"Feng","year":"2000","journal-title":"Mol Endocrinol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","volume":"127","author":"Lagouge","year":"2006","journal-title":"Cell"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"30365","DOI":"10.1074\/jbc.M113.504845","volume":"288","author":"Singh","year":"2013","journal-title":"J Biol Chem"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1096\/fj.08-108464","volume":"22","author":"Perra","year":"2008","journal-title":"FASEB J"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1506113113","volume":"113","author":"Alonso-Merino","year":"2016","journal-title":"Proc Natl Acad Sci"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1089\/thy.2018.0664","volume":"29","author":"Sinha","year":"2019","journal-title":"Thyroid"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1089\/thy.2019.0007","volume":"29","author":"Zhou","year":"2019","journal-title":"Thyroid"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"15490","DOI":"10.1073\/pnas.0702759104","volume":"104","author":"Erion","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1089\/thy.2012.0458","volume":"23","author":"Meruvu","year":"2013","journal-title":"Thyroid"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"E150","DOI":"10.1016\/S0618-8278(19)30266-X","volume":"701","author":"Loomba","year":"2019","journal-title":"J Hepatol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jcmgh.2019.04.007","volume":"8","author":"Esler","year":"2019","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"ref58","first-page":"13","volume":"20","author":"Alkhouri","year":"2024","journal-title":"Gastroenterol Hepatol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S1074-5521(98)90168-5","volume":"5","author":"Chiellini","year":"1998","journal-title":"Chem Biol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"E89","DOI":"10.1152\/ajpendo.00573.2012","volume":"305","author":"Vatner","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/nrd2830","volume":"8","author":"Baxter","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1073\/pnas.0705286104","volume":"105","author":"Berkenstam","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/S2213-8587(14)70006-3","volume":"2","author":"Sjouke","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.atherosclerosis.2013.07.056","volume":"230","author":"Taub","year":"2013","journal-title":"Atherosclerosis"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1016\/S0140-6736(19)32517-6","volume":"394","author":"Harrison","year":"2019","journal-title":"Lancet"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.jhep.2021.08.016","volume":"75","author":"Nielsen","year":"2021","journal-title":"J Hepatol"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.cgh.2021.07.039","volume":"20","author":"Younossi","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1056\/NEJMoa2309000","volume":"390","author":"Harrison","year":"2024","journal-title":"N Engl J Med"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1038\/s41591-023-02603-1","volume":"29","author":"Harrison","year":"2023","journal-title":"Nat Med"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/apt.17734","volume":"59","author":"Harrison","year":"2024","journal-title":"Aliment Pharmacol Ther"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1097\/HEP.0000000000001084","volume":"81","author":"Younossi","year":"2025","journal-title":"Hepatology"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"112006","DOI":"10.1016\/j.ejmech.2019.112006","volume":"188","author":"Runfola","year":"2020","journal-title":"Eur J Med Chem"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"865","DOI":"10.2174\/1573399811666150615150235","volume":"17","author":"Gasparrini","year":"2016","journal-title":"Curr Drug Targets"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"13105","DOI":"10.3390\/ijms222313105","volume":"22","author":"Caddeo","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1127517","DOI":"10.3389\/fonc.2023.1127517","volume":"13","author":"Caddeo","year":"2023","journal-title":"Front Oncol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"e12808","DOI":"10.1111\/cpr.12808","volume":"53","author":"Perra","year":"2020","journal-title":"Cell Prolif"},{"key":"ref77","unstructured":"Ascletis Pharma Inc. DDI study of ASC41 in HV and the PK, safety and tolerability in subjects with NAFLD. Available from: https:\/\/www.clinicaltrials.gov\/study\/NCT04845646?term=gannex&viewType=Table&rank=7. Accessed August 4, 2025."},{"key":"ref78","unstructured":"Ascletis Pharma Inc. A study of the relative bioavailability of ASC41 in healthy subjects. Available from: https:\/\/www.clinicaltrials.gov\/study\/NCT04527250?term=ascletis&viewType=Table&page=4&rank=32. Accessed August 4, 2025."},{"key":"ref79","unstructured":"Ascletis Pharma Inc. Study to evaluate the safety, tolerability, and efficacy of ASC41 tablets in adult patients with NASH. Available from: https:\/\/www.clinicaltrials.gov\/study\/NCT05462353?term=gannex&viewType=Table&rank=2#study-record-dates. Accessed August 4, 2025."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1080\/13543784.2020.1708899","volume":"29","author":"Alkhouri","year":"2020","journal-title":"Expert Opin Investig Drugs"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/109187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/109187","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T08:20:18Z","timestamp":1763972418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/targeting-thr--for-masld-mechanisms-and-drug-development-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":80,"URL":"https:\/\/doi.org\/10.2147\/dddt.s558221","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}