{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:52:56Z","timestamp":1790113976998,"version":"4.0.1"},"reference-count":45,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s566113","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:35:19Z","timestamp":1768998919000},"page":"1-21","source":"Crossref","is-referenced-by-count":2,"title":["Therapeutic Efficacy of Curcumin Nanoparticles in Parkinson\u2019s Disease: An Integrated Analysis of Network Pharmacology, Experimental Validation, and Gut Microbiota"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Runhong","family":"Mu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengda","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Xiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2712-3767","authenticated-orcid":true,"given":"Xiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1007\/s10072-024-07941-7","volume":"46","author":"Zhang","year":"2025","journal-title":"Neurol Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3736","DOI":"10.3390\/cells11233736","volume":"11","author":"Kwon","year":"2022","journal-title":"Cells"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.2147\/DDDT.S492033","volume":"19","author":"Sun","year":"2025","journal-title":"Drug Des Devel Ther"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.2147\/DDDT.S450324","volume":"18","author":"Cai","year":"2024","journal-title":"Drug Des Devel Ther"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.2147\/DDDT.S473678","volume":"19","author":"Li","year":"2025","journal-title":"Drug Des Devel Ther"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"5747","DOI":"10.1002\/jsfa.11372","volume":"101","author":"Abd El-Hack","year":"2021","journal-title":"J Sci Food Agric"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3390\/nu12020501","volume":"12","author":"Fern\u00e1ndez-L\u00e1zaro","year":"2020","journal-title":"Nutrients"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.neulet.2009.09.055","volume":"467","author":"Timmons","year":"2009","journal-title":"Neurosci Lett"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"bbad518","DOI":"10.1093\/bib\/bbad518","volume":"25","author":"Zhang","year":"2023","journal-title":"Brief Bioinform"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"7096","DOI":"10.1002\/jsfa.13509","volume":"104","author":"Li","year":"2024","journal-title":"J Sci Food Agric"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"796288","DOI":"10.3389\/fimmu.2022.796288","volume":"13","author":"Mou","year":"2022","journal-title":"Front Immunol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41531-022-00295-x","volume":"8","author":"Warnecke","year":"2022","journal-title":"NPJ Parkinsons Dis"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"937555","DOI":"10.3389\/fimmu.2022.937555","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Immunol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/mds.26069","volume":"30","author":"Scheperjans","year":"2015","journal-title":"Mov Disord"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"108568","DOI":"10.1016\/j.biotechadv.2025.108568","volume":"82","author":"Lagoa","year":"2025","journal-title":"Biotechnol Adv"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"155119","DOI":"10.1016\/j.phymed.2023.155119","volume":"121","author":"Lin","year":"2023","journal-title":"Phytomedicine"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1002\/mds.28004","volume":"35","author":"Elfil","year":"2020","journal-title":"Mov Disord"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1093\/brain\/awab156","volume":"144","author":"Wang","year":"2021","journal-title":"Brain"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.bbi.2023.11.004","volume":"115","author":"Boyton","year":"2024","journal-title":"Brain, Behav Immun"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s00702-025-02893-4","volume":"132","author":"Riederer","year":"2025","journal-title":"J Neural Transm"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.14200\/jrm.2017.6.0101","volume":"6","author":"Toden","year":"2017","journal-title":"J Restor Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3390\/antibiotics11020135","volume":"11","author":"Uro\u0161evi\u0107","year":"2022","journal-title":"Antibiotics"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"4400","DOI":"10.3390\/molecules27144400","volume":"27","author":"Liu","year":"2022","journal-title":"Molecules"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3390\/molecules27010236","volume":"27","author":"Benameur","year":"2021","journal-title":"Molecules"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"824652","DOI":"10.3389\/fphar.2022.824652","volume":"13","author":"Chen","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"6652","DOI":"10.3390\/molecules27196652","volume":"27","author":"J\u00f3zsa","year":"2022","journal-title":"Molecules"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"8049","DOI":"10.2147\/IJN.S334965","volume":"16","author":"Yang","year":"2021","journal-title":"Int J Nanomed"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"156547","DOI":"10.1016\/j.phymed.2025.156547","volume":"140","author":"Guo","year":"2025","journal-title":"Phytomedicine"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jconrel.2024.06.005","volume":"372","author":"Du","year":"2024","journal-title":"J Control Release"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1073\/pnas.0914876107","volume":"107","author":"Aleyasin","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"105344","DOI":"10.1016\/j.neuint.2022.105344","volume":"157","author":"Ali","year":"2022","journal-title":"Neurochem Int"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41531-023-00453-9","volume":"9","author":"Zhang","year":"2023","journal-title":"NPJ Parkinsons Dis"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"107636","DOI":"10.1016\/j.ultsonch.2025.107636","volume":"122","author":"Meng","year":"2025","journal-title":"Ultrason Sonochem"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41419-025-07732-8","volume":"16","author":"Lv","year":"2025","journal-title":"Cell Death Dis"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.3390\/microorganisms12112333","volume":"12","author":"Khalil","year":"2024","journal-title":"Microorganisms"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/s0197-4580(02)00065-9","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol Aging"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.bbi.2025.04.001","volume":"128","author":"Wu","year":"2025","journal-title":"Brain Behav Immun"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s11481-025-10176-8","volume":"20","author":"Hassan","year":"2025","journal-title":"J Neuroimmune Pharmacol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"6612","DOI":"10.1007\/s12035-025-04726-7","volume":"62","author":"Qu","year":"2025","journal-title":"Mol Neurobiol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"e14411","DOI":"10.1111\/cns.14411","volume":"30","author":"Li","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40035-025-00467-8","volume":"14","author":"Chen","year":"2025","journal-title":"Transl Neurodegener"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"422","DOI":"10.17305\/bjbms.2020.5181","volume":"21","author":"Mustapha","year":"2021","journal-title":"Bosn J Basic Med Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.neuro.2021.11.011","volume":"88","author":"Yildirim","year":"2022","journal-title":"Neurotoxicology"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"19961","DOI":"10.1021\/acsnano.3c05011","volume":"17","author":"Xu","year":"2023","journal-title":"ACS Nano"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/111213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/111213","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:35:19Z","timestamp":1768998919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/therapeutic-efficacy-of-curcumin-nanoparticles-in-parkinsons-disease-a-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":45,"URL":"https:\/\/doi.org\/10.2147\/dddt.s566113","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}