{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:03:42Z","timestamp":1776668622838,"version":"3.51.2"},"reference-count":62,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s566649","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:10:11Z","timestamp":1776665411000},"page":"1-21","source":"Crossref","is-referenced-by-count":0,"title":["\u03b2-Amyrin Acetate Confers Anti-Epileptic Protection via Suppression of Calcium Overload-Induced Neuroinflammation and Apoptosis"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Jiali","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaojian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueke","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26094035","volume":"26","author":"Li","year":"2025","journal-title":"Int J Mol Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/epi.13709","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e000650","DOI":"10.1136\/bmjno-2024-000650","volume":"6","author":"Ratnaike","year":"2024","journal-title":"BMJ Neurol Open"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"155022","DOI":"10.1016\/j.phymed.2023.155022","volume":"120","author":"Wu","year":"2023","journal-title":"Phytomedicine"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.3109\/13880209.2014.898078","volume":"52","author":"Okoye","year":"2014","journal-title":"Pharm Biol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3109\/13880209.2014.923001","volume":"53","author":"Arag\u00e3o","year":"2015","journal-title":"Pharm Biol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"S578","DOI":"10.1016\/j.ibneur.2023.08.1145","volume":"15","author":"Henneh","year":"2023","journal-title":"IBRO Neurosci Rep"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.3390\/ph17081018","volume":"17","author":"Angsusing","year":"2024","journal-title":"Pharmaceuticals"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/s0169-409x(00)00129-0","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv Drug Deliv Rev"},{"key":"ref10","volume-title":"The Practice of Medicinal Chemistry","year":"2015"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s42494-023-00137-0","volume":"5","author":"Sumadewi","year":"2023","journal-title":"Acta Epileptol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nn.3947","volume":"18","author":"Staley","year":"2015","journal-title":"Nat Neurosci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.neuropharm.2018.01.036","volume":"136","author":"Olsen","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3390\/biomedicines11030783","volume":"11","author":"Chen","year":"2023","journal-title":"Biomedicines"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3390\/antiox11010157","volume":"11","author":"Parsons","year":"2022","journal-title":"Antioxidants"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1126\/science.290.5489.144","volume":"290","author":"Simon","year":"2000","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"11757","DOI":"10.1021\/acs.jafc.8b04704","volume":"66","author":"Liu","year":"2018","journal-title":"J Agric Food Chem"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"8245614","DOI":"10.1155\/2022\/8245614","volume":"2022","author":"Jia","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"7702","DOI":"10.3390\/ijms24097702","volume":"24","author":"D\u2019Amora","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"114920","DOI":"10.1016\/j.bbr.2024.114920","volume":"464","author":"Okanari","year":"2024","journal-title":"Behav Brain Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.neuroscience.2025.01.048","volume":"568","author":"Fontana","year":"2025","journal-title":"Neuroscience"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e54166","DOI":"10.1371\/journal.pone.0054166","volume":"8","author":"Afrikanova","year":"2013","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e77548","DOI":"10.1371\/journal.pone.0077548","volume":"8","author":"Fleming","year":"2013","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"109594","DOI":"10.1016\/j.jneumeth.2022.109594","volume":"375","author":"Shaw","year":"2022","journal-title":"J Neurosci Methods"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1055424","DOI":"10.3389\/fphar.2022.1055424","volume":"13","author":"Shin","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"488","DOI":"10.4103\/mgr.MEDGASRES-D-24-00161","volume":"15","author":"Liu","year":"2025","journal-title":"Med Gas Res"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"6687185","DOI":"10.1155\/2020\/6687185","volume":"2020","author":"Yang","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"293689","DOI":"10.1155\/2014\/293689","volume":"2014","author":"M\u00e9ndez-Armenta","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/j.1750-3639.1993.tb00766.x","volume":"3","author":"Kiessling","year":"1993","journal-title":"Brain Pathol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1002\/cne.25044","volume":"529","author":"Magalh\u00e3es","year":"2021","journal-title":"J Comp Neurol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"902","DOI":"10.62641\/aep.v53i4.1790","volume":"53","author":"Cao","year":"2025","journal-title":"Actas Esp Psiquiatr"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.tox.2016.07.022","volume":"365","author":"Lee","year":"2016","journal-title":"Toxicology"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/epi4.13098","volume":"10","author":"Hashmi","year":"2025","journal-title":"Epilepsia Open"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/fcp.12402","volume":"33","author":"Nogueira","year":"2019","journal-title":"Fundam Clin Pharmacol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"894","DOI":"10.3390\/biom10060894","volume":"10","author":"AlQathama","year":"2020","journal-title":"Biomolecules"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neubiorev.2020.06.010","volume":"116","author":"Gawel","year":"2020","journal-title":"Neurosci Biobehav Rev"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.neuroscience.2004.11.031","volume":"131","author":"Baraban","year":"2005","journal-title":"Neuroscience"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1007\/s11011-022-01018-0","volume":"37","author":"Zhao","year":"2022","journal-title":"Metab Brain Dis"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1089\/ars.2011.4391","volume":"18","author":"Lewerenz","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"5507","DOI":"10.2174\/138161282035140911142118","volume":"20","author":"Valero","year":"2014","journal-title":"Curr Pharm Des"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"100459","DOI":"10.1016\/j.prmcm.2024.100459","volume":"12","author":"Manish","year":"2024","journal-title":"Pharmacol Res Mod Chin Med"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"111859","DOI":"10.1016\/j.intimp.2024.111859","volume":"131","author":"Murugan","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.3390\/ijms22031285","volume":"22","author":"Kim","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14728222.2019.1554056","volume":"23","author":"Rojas","year":"2019","journal-title":"Expert Opin Ther Targets"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1046\/j.1460-9568.2001.01420.x","volume":"13","author":"Kunz","year":"2001","journal-title":"Eur J Neurosci"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.neuroscience.2004.01.045","volume":"125","author":"Gobbo","year":"2004","journal-title":"Neuroscience"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.brainresbull.2016.12.010","volume":"130","author":"Ta\u015fk\u0131ran","year":"2017","journal-title":"Brain Res Bull"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1161\/circresaha.107.165936","volume":"102","author":"Arehart","year":"2008","journal-title":"Circ Res"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1007\/s43440-023-00536-7","volume":"75","author":"Chitolina","year":"2023","journal-title":"Pharmacol Rep"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neubiorev.2015.04.015","volume":"55","author":"Deepmala","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"106989","DOI":"10.1016\/j.nbd.2025.106989","volume":"212","author":"Li","year":"2025","journal-title":"Neurobiol Dis"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1113\/jp283826","volume":"602","author":"Courjaret","year":"2024","journal-title":"J Physiol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"5391","DOI":"10.1113\/jp280119","volume":"598","author":"Hori","year":"2020","journal-title":"J Physiol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.expneurol.2011.08.022","volume":"232","author":"Steinbeck","year":"2011","journal-title":"Exp Neurol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"e26141","DOI":"10.4161\/jkst.26141","volume":"2","author":"Duh\u00e9","year":"2013","journal-title":"JAK-STAT"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.2174\/1570159x21666221214170234","volume":"21","author":"Sun","year":"2023","journal-title":"Curr Neuropharmacol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"417","DOI":"10.2174\/1566524020666201015144702","volume":"21","author":"Sopjani","year":"2021","journal-title":"Curr Mol Med"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"118083","DOI":"10.1016\/j.lfs.2020.118083","volume":"257","author":"Yin","year":"2020","journal-title":"Life Sci"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bbi.2019.01.027","volume":"79","author":"Kong","year":"2019","journal-title":"Brain Behav Immun"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"174620","DOI":"10.1016\/j.ejphar.2021.174620","volume":"912","author":"Hu","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s12974-024-03210-8","volume":"21","author":"Hong","year":"2024","journal-title":"J Neuroinflammation"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"eadt0527","DOI":"10.1126\/scitranslmed.adt0527","volume":"17","author":"Hoffman","year":"2025","journal-title":"Sci Transl Med"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/114250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/114250","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:10:12Z","timestamp":1776665412000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/-amyrin-acetate-confers-anti-epileptic-protection-via-suppression-of-c-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":62,"URL":"https:\/\/doi.org\/10.2147\/dddt.s566649","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}