{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:22:44Z","timestamp":1770250964099,"version":"3.49.0"},"reference-count":28,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s571808","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T11:20:13Z","timestamp":1770204013000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Determination of Median Effective Concentration (EC50) of Ropivacaine with Adjuvant Dexmedetomidine When Using the Dural Puncture Epidural Technique for Labor Analgesia: An Up-Down Sequential Allocation Study"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/anae.16433","volume":"80","author":"Zang","year":"2025","journal-title":"Anaesthesia"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1213\/ANE.0000000000001798","volume":"124","author":"Chau","year":"2017","journal-title":"Anesth Analg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1213\/ane.0b013e318184ec14","volume":"107","author":"Cappiello","year":"2008","journal-title":"Anesth Analg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s00540-022-03061-8","volume":"36","author":"Yin","year":"2022","journal-title":"J Clin Anesth"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1213\/ANE.0000000000002129","volume":"126","author":"Wilson","year":"2018","journal-title":"Anesth Analg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1097\/EJA.0000000000000347","volume":"32","author":"Roelants","year":"2015","journal-title":"Eur J Anaesthesiol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ijoa.2019.09.004","volume":"41","author":"Grangier","year":"2020","journal-title":"Int J Obstet Anesth"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"7507","DOI":"10.2147\/JIR.S346089","volume":"14","author":"Liu","year":"2021","journal-title":"J Inflamm Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fphar.2020.00342","author":"Bi","year":"2020","journal-title":"Front Pharmacol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1177\/0300060517698330","volume":"45","author":"Wang","year":"2017","journal-title":"J Int Med Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1097\/AJP.0000000000001166","volume":"40","author":"Zhang","year":"2024","journal-title":"Clin J Pain"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"842","DOI":"10.23736\/S0375-9393.22.16284-X","volume":"88","author":"Zhou","year":"2022","journal-title":"Minerva Anestesiol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.2147\/DDDT.S197431","volume":"13","author":"Zhang","year":"2019","journal-title":"Drug Des Dev Ther"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7924148","author":"Zhang","year":"2017","journal-title":"Evid-Based Complementary Altern Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520946171","volume":"48","author":"Wang","year":"2020","journal-title":"J Int Med Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fphar.2023.1205301","author":"Shen","year":"2023","journal-title":"Front Pharmacol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jclinane.2020.110115","author":"Liu","year":"2021","journal-title":"J Clin Anesth"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/01.anes.0000267514.42592.2a","volume":"107","author":"Pace","year":"2007","journal-title":"Anesthesiology"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/jis\/3.1.34","volume":"3","author":"Payton","year":"2003","journal-title":"J Insect Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3892\/etm.2020.8730","volume":"20","author":"Li","year":"2020","journal-title":"Exp Ther Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.21037\/apm-22-264","volume":"11","author":"Fan","year":"2022","journal-title":"Ann Palliat Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jclinane.2020.109725","volume":"60","author":"Tang","year":"2020","journal-title":"J Clin Anesth"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"609","DOI":"10.2147\/DDDT.S346842","volume":"16","author":"Ni","year":"2022","journal-title":"Drug Des Dev Ther"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.jclinane.2018.09.030","volume":"53","author":"Layera","year":"2019","journal-title":"J Clin Anesth"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.intimp.2021.107709","author":"Yuki","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.bja.2019.07.027","volume":"123","author":"Wang","year":"2019","journal-title":"Brit J Anaesth"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2023\/2358888","volume":"2023","author":"Ge","year":"2023","journal-title":"Emerg Med Int"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3389\/fmed.2022.922611","author":"Zhang","year":"2022","journal-title":"Front Med"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/111664","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/111664","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T11:20:13Z","timestamp":1770204013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/determination-of-median-effective-concentration-ec50-of-ropivacaine-wi-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":28,"URL":"https:\/\/doi.org\/10.2147\/dddt.s571808","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]}}}