{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:47:39Z","timestamp":1776876459004,"version":"3.51.2"},"reference-count":32,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s575242","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:05:14Z","timestamp":1776873914000},"page":"1-23","source":"Crossref","is-referenced-by-count":0,"title":["Structure-Based Discovery of Glyoxalase-I Inhibitors: Evaluating the Role of Active Site Water Molecules"],"prefix":"10.2147","volume":"Volume 20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4331-7638","authenticated-orcid":true,"given":"Reema","family":"Anaam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4342-5370","authenticated-orcid":true,"given":"Israa","family":"Isawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8350-900X","authenticated-orcid":true,"given":"Qosay","family":"Al-Balas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,4]]},"reference":[{"key":"ref1","unstructured":"Cancer Tomorrow. Available from: https:\/\/gco.iarc.who.int\/tomorrow\/en\/dataviz\/trends?multiple_populations=1. Accessed April 17, 2025."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/S12957-016-0769-9","volume":"14","author":"Li","year":"2016","journal-title":"World J Surg Oncol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/J.1432-1033.1993.TB17638.X","volume":"212","author":"Phillips","year":"1993","journal-title":"Eur J Biochem"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj2690001","volume":"269","author":"Thornalley","year":"1990","journal-title":"Biochem J"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1023\/A:1010632919129","volume":"66","author":"Rulli","year":"2001","journal-title":"Breast Cancer Res Treat"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e34352","DOI":"10.1371\/journal.pone.0034352","volume":"7","author":"Cheng","year":"2012","journal-title":"PLoS One"},{"key":"ref7","first-page":"3219","volume":"32","author":"Wang","year":"2012","journal-title":"Anticancer Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"54838","DOI":"10.18632\/oncotarget.18601","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1002\/pros.23431","volume":"77","author":"Burdelski","year":"2017","journal-title":"Prostate"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.biopha.2019.108712","author":"Jiang","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"ref11","doi-asserted-by":"publisher","volume-title":"Handbook of Oxidative Stress in Cancer: Mechanistic Aspects","year":"2022","DOI":"10.1007\/978-981-15-9411-3_12"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2174\/1389557518666181009141231","volume":"19","author":"Al-Balas","year":"2019","journal-title":"Mini-Rev Med Chem"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"869","DOI":"10.14348\/molcells.2022.0109","volume":"45","author":"Kim","year":"2022","journal-title":"Mol Cells"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"21623","DOI":"10.1074\/jbc.273.34.21623","volume":"273","author":"Ridderstr\u00f6m","year":"1998","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1021\/JM00287A006","volume":"14","author":"Vince","year":"1971","journal-title":"J Med Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"24933","DOI":"10.1016\/S0021-9258(19)73986-6","volume":"267","author":"Hamilton","year":"1992","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"3969","DOI":"10.1016\/J.BMC.2008.01.031","volume":"16","author":"Takasawa","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"7029","DOI":"10.1016\/J.BMC.2010.08.012","volume":"18","author":"Takasawa","year":"2010","journal-title":"Bioorg Med Chem"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s10822-019-00226-8","volume":"33","author":"Al-Shar\u2019i","year":"2019","journal-title":"J Comput Aided Mol Des"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2174\/156802610790232288","volume":"10","author":"de Beer","year":"2010","journal-title":"Curr Top Med Chem"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1021\/ci400052w","volume":"53","author":"Kumar","year":"2013","journal-title":"J Chem Inf Model"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/BF00124323","volume":"9","author":"Poornima","year":"1995","journal-title":"J Comput Aided Mol Des"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1437S","DOI":"10.1093\/jn\/130.5.1437S","volume":"130","author":"McCall","year":"2000","journal-title":"J Nutr"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"13480","DOI":"10.1021\/bi990696c","volume":"38","author":"Cameron","year":"1999","journal-title":"Biochemistry"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.1016\/S0021-9258(18)33979-6","volume":"257","author":"Sellin","year":"1982","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"13740","DOI":"10.3390\/molecules171213740","volume":"17","author":"Al-Balas","year":"2012","journal-title":"Molecules"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"814","DOI":"10.2174\/1573409916666200117100326","volume":"16","author":"Al-Sha\u2019er","year":"2021","journal-title":"Curr Comput Aided Drug Des"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"7486","DOI":"10.1016\/j.bmcl.2012.10.045","volume":"22","author":"Chiba","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1002\/1873-3468.14344","volume":"596","author":"Usami","year":"2022","journal-title":"FEBS Lett"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"3386","DOI":"10.1093\/emboj\/16.12.3386","volume":"16","author":"Cameron","year":"1997","journal-title":"EMBO J"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.2147\/DDDT.S110997","volume":"10","author":"Al-Balas","year":"2016","journal-title":"Drug Des Devel Ther"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/5104464","volume":"2022","author":"Xiao","year":"2022","journal-title":"Comput Math Meth Med"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/114429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/114429","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:05:17Z","timestamp":1776873917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/structure-based-discovery-of-glyoxalase-i-inhibitors-evaluating-the-ro-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":32,"URL":"https:\/\/doi.org\/10.2147\/dddt.s575242","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}