{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:35:39Z","timestamp":1784925339189,"version":"3.55.0"},"reference-count":81,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s575608","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:05:13Z","timestamp":1770210313000},"page":"1-19","source":"Crossref","is-referenced-by-count":3,"title":["Properties of Approved Antitumour Chinese Herbal Medicines: Integrating Evidence and Tradition"],"prefix":"10.2147","volume":"Volume 20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5816-8402","authenticated-orcid":true,"given":"Linlin","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shushu","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2681-0349","authenticated-orcid":true,"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3834","DOI":"10.19540\/j.cnki.cjcmm.20180709.006","volume":"43","author":"Lu","year":"2018","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1177\/1534735415572880","volume":"14","author":"Zhu","year":"2015","journal-title":"Integr Cancer Ther"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1021\/acs.jnatprod.7b00151","volume":"80","author":"Tuan","year":"2017","journal-title":"J Nat Prod"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"142","DOI":"10.5493\/wjem.v13.i5.142","volume":"13","author":"Panchal","year":"2023","journal-title":"World J Exp Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/jpp\/rgac067","volume":"75","author":"Li","year":"2023","journal-title":"J Pharm Pharmacol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1097\/HM9.0000000000000121","volume":"4","author":"Yan","year":"2024","journal-title":"Acupuncture Herbal Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"112800","DOI":"10.1016\/j.biopha.2022.112800","volume":"149","author":"Wang","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1016\/j.apsb.2021.05.009","volume":"11","author":"Huang","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1186\/s12935-021-02150-0","volume":"21","author":"Niu","year":"2021","journal-title":"Cancer Cell Int"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40659-017-0150-7","volume":"51","author":"Wei","year":"2018","journal-title":"Biol Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/s12935-019-0960-5","volume":"19","author":"Tian","year":"2019","journal-title":"Cancer Cell Int"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"18600","DOI":"10.1002\/jcb.28696","volume":"120","author":"Guo","year":"2019","journal-title":"J Cell Biochem"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1007\/s11033-019-04656-3","volume":"46","author":"Arshi","year":"2019","journal-title":"Mol Biol Rep"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.sjbs.2018.01.012","volume":"25","author":"Chen","year":"2018","journal-title":"Saudi J Biol Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.omto.2021.08.013","volume":"23","author":"Liu","year":"2021","journal-title":"Mol Ther Oncolytics"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.joim.2023.10.002","volume":"21","author":"Yang","year":"2023","journal-title":"J Integr Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3390\/molecules18010757","volume":"18","author":"Du","year":"2013","journal-title":"Molecules"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25051196","volume":"25","author":"Subhawa","year":"2020","journal-title":"Molecules"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol Pathol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.3892\/ol.2019.10182","volume":"17","author":"Telang","year":"2019","journal-title":"Oncol Lett"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/j.bcp.2013.03.006","volume":"85","author":"Shanmugam","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.3748\/wjg.14.3990","volume":"14","author":"Liu","year":"2008","journal-title":"World J Gastroenterol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1002\/eji.201847688","volume":"48","author":"Liu","year":"2018","journal-title":"Eur J Immunol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"4842","DOI":"10.1021\/acs.jafc.8b00658","volume":"66","author":"Zopun","year":"2018","journal-title":"J Agric Food Chem"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10549-021-06133-7","volume":"187","author":"Ware","year":"2021","journal-title":"Breast Cancer Res Treat"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114177","volume":"21","author":"Zhai","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s13046-020-01707-7","volume":"39","author":"Gao","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25194423","volume":"25","author":"Behrens","year":"2020","journal-title":"Molecules"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1021\/acs.jmedchem.7b01803","volume":"61","author":"Facchini","year":"2018","journal-title":"J Med Chem"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/cbdd.13089","volume":"91","author":"Behrens","year":"2018","journal-title":"Chem Biol Drug Des"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1111\/bph.13465","volume":"173","author":"Veale","year":"2016","journal-title":"Br J Pharmacol"},{"key":"ref32","first-page":"641","volume":"19","author":"Li","year":"2020","journal-title":"Excli J"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/cbdd.12293","volume":"84","author":"Ji","year":"2014","journal-title":"Chem Biol Drug Des"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.cophys.2021.01.006","volume":"20","author":"Harmon","year":"2021","journal-title":"Curr Opin Physiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1186\/s12967-021-03137-1","volume":"19","author":"Tuzim","year":"2021","journal-title":"J Transl Med"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"15358","DOI":"10.1074\/jbc.M116.718544","volume":"291","author":"Lossow","year":"2016","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"4037","DOI":"10.1096\/fj.201601323RR","volume":"31","author":"Zheng","year":"2017","journal-title":"FASEB J"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"113954","DOI":"10.1016\/j.bcp.2020.113954","volume":"177","author":"Duarte","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"G457","DOI":"10.1152\/ajpgi.00411.2006","volume":"292","author":"Sternini","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s11010-019-03679-5","volume":"465","author":"Singh","year":"2020","journal-title":"Mol Cell Biochem"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"e0176851","DOI":"10.1371\/journal.pone.0176851","volume":"12","author":"Seo","year":"2017","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1002\/1878-0261.13131","volume":"16","author":"Carey","year":"2022","journal-title":"Mol Oncol"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25136849","volume":"25","author":"Bi","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s11010-018-3464-z","volume":"454","author":"Martin","year":"2019","journal-title":"Mol Cell Biochem"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3724\/abbs.2022026","volume":"54","author":"Liu","year":"2022","journal-title":"Acta Biochim Biophys Sin"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"711","DOI":"10.7150\/jca.21803","volume":"9","author":"Stern","year":"2018","journal-title":"J Cancer"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"12623","DOI":"10.18632\/oncotarget.7206","volume":"7","author":"Gaida","year":"2016","journal-title":"Oncotarget"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"301","DOI":"10.2147\/ott.S282334","volume":"14","author":"Fu","year":"2021","journal-title":"Onco Targets Ther"},{"key":"ref49","first-page":"6926","volume":"8","author":"Lv","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"C726","DOI":"10.1152\/ajpcell.00003.2006","volume":"291","author":"Chen","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1080\/01635581.2019.1637006","volume":"72","author":"Hazafa","year":"2020","journal-title":"Nutr Cancer"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/ptr.2066","volume":"21","author":"Sun","year":"2007","journal-title":"Phytother Res"},{"key":"ref53","first-page":"369","volume":"68","author":"Zhang","year":"2013","journal-title":"Pharmazie"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s00210-015-1127-0","volume":"388","author":"Zhu","year":"2015","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"7377","DOI":"10.1002\/jcb.27041","volume":"119","author":"Park","year":"2018","journal-title":"J Cell Biochem"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41538-025-00370-6","volume":"9","author":"Liang","year":"2025","journal-title":"NPJ Sci Food"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.3390\/biology10090849","volume":"10","author":"\u0160kubn\u00edk","year":"2021","journal-title":"Biology"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10616-009-9211-2","volume":"59","author":"Zhang","year":"2009","journal-title":"Cytotechnology"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/s00210-003-0691-x","volume":"367","author":"Frederich","year":"2003","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00280-014-2651-1","volume":"75","author":"Guo","year":"2015","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1159\/000493615","volume":"49","author":"Liu","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.3892\/ol.2018.8806","volume":"16","author":"Wang","year":"2018","journal-title":"Oncol Lett"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s00280-014-2408-x","volume":"73","author":"Xiao","year":"2014","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.3390\/plants10102067","volume":"10","author":"Kim","year":"2021","journal-title":"Plants"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s13659-021-00321-0","volume":"11","author":"Zhang","year":"2021","journal-title":"Nat Prod Bioprospect"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"2822950","DOI":"10.1155\/2021\/2822950","volume":"2021","author":"Chi","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1002\/tox.22943","volume":"35","author":"Lin","year":"2020","journal-title":"Environ Toxicol Int J"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnab077","volume":"368","author":"Veerabhadrappa","year":"2021","journal-title":"FEMS Microbiol Lett"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1097\/cad.0000000000000154","volume":"25","author":"Wang","year":"2014","journal-title":"Anticancer Drugs"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s12032-014-0270-7","volume":"31","author":"Wang","year":"2014","journal-title":"Med Oncol"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s12032-014-0014-8","volume":"31","author":"Wu","year":"2014","journal-title":"Med Oncol"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.2147\/jpr.S456874","volume":"17","author":"Zhu","year":"2024","journal-title":"J Pain Res"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s11726-020-1188-6","volume":"18","author":"Chen","year":"2020","journal-title":"J Acupunct Tuina Sci"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/HM9.0000000000000096","volume":"4","author":"Huang","year":"2024","journal-title":"Acupuncture Herbal Med"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41575-024-01005-z","volume":"22","author":"Sternini","year":"2025","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.jgr.2019.05.004","volume":"44","author":"Yu","year":"2020","journal-title":"J Ginseng Res"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"5476","DOI":"10.1039\/d4ra07212j","volume":"15","author":"Fang","year":"2025","journal-title":"RSC Adv"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cancergen.2024.06.002","volume":"286-287","author":"Sonkin","year":"2024","journal-title":"Cancer Genet"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.26717\/bjstr.2020.30.004979","volume":"30","author":"Liu","year":"2020","journal-title":"Biomed J Scientific Techn Res"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.20517\/2394-4722.2023.134","author":"McBrearty","year":"2024","journal-title":"J Cancer Metastatis Treat"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/ot9.0000000000000039","author":"Joshia","year":"2024","journal-title":"Oncol Transl Med"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/111685","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/111685","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:05:15Z","timestamp":1770210315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/properties-of-approved-antitumour-chinese-herbal-medicines-integrating-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":81,"URL":"https:\/\/doi.org\/10.2147\/dddt.s575608","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]}}}