{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:45:28Z","timestamp":1792035928433,"version":"4.4.0"},"reference-count":46,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s577058","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:50:13Z","timestamp":1777301413000},"page":"1-20","source":"Crossref","is-referenced-by-count":1,"title":["Linoleic Acid Reduces Paclitaxel Chemosensitivity in Colorectal Cancer"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Bingwen","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13046-021-02224-x","volume":"41","author":"Zhu","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1080\/21691401.2023.2193221","volume":"51","author":"Guo","year":"2023","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"S163","DOI":"10.1016\/0169-5002(95)00432-z","volume":"12","author":"Francis","year":"1995","journal-title":"Lung Cancer"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"eabd4811","DOI":"10.1126\/scitranslmed.abd4811","volume":"13","author":"Scribano","year":"2021","journal-title":"Sci Transl Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1038\/s41598-017-01480-2","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/sj.cdd.4401054","volume":"9","author":"Brognard","year":"2002","journal-title":"Cell Death Differ"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1200\/JCO.2015.61.3026","volume":"33","author":"Murphy","year":"2015","journal-title":"J Clin Oncol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.ccell.2023.05.009","volume":"41","author":"Vennin","year":"2023","journal-title":"Cancer Cell"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1002\/jcb.29374","volume":"121","author":"Hejazi","year":"2020","journal-title":"J Cell Biochem"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"5235","DOI":"10.1088\/0031-9155\/57\/16\/5235","volume":"57","author":"Zhang","year":"2012","journal-title":"Phys Med Biol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"107116","DOI":"10.1016\/j.isci.2023.107116","volume":"26","author":"Tang","year":"2023","journal-title":"iScience"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1053\/j.gastro.2021.10.007","volume":"162","author":"Patel","year":"2022","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1158\/1538-7445.AM2017-815","volume":"77","author":"Jin","year":"2017","journal-title":"Cancer Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1056\/NEJMra1806175","volume":"380","author":"Li","year":"2019","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.gendis.2023.02.052","volume":"11","author":"Ma","year":"2023","journal-title":"Genes Dis"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s13046-023-02853-4","volume":"42","author":"Cartry","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1190637","DOI":"10.3389\/fbioe.2023.1190637","volume":"11","author":"He","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"eaay2574","DOI":"10.1126\/scitranslmed.aay2574","volume":"11","author":"Ooft","year":"2019","journal-title":"Sci Transl Med"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e2204097","DOI":"10.1002\/advs.202204097","volume":"9","author":"Mo","year":"2022","journal-title":"Adv Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"5376","DOI":"10.1158\/1078-0432.CCR-18-3590","volume":"25","author":"Pasch","year":"2019","journal-title":"Clin Cancer Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.stem.2019.10.010","volume":"26","author":"Yao","year":"2020","journal-title":"Cell Stem Cell"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/s41568-018-0007-6","volume":"18","author":"Drost","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.tips.2024.04.007","volume":"45","author":"Terry","year":"2024","journal-title":"Trends Pharmacol Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"216352","DOI":"10.1016\/j.canlet.2023.216352","volume":"572","author":"Qin","year":"2023","journal-title":"Cancer Lett"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41387-025-00367-w","volume":"15","author":"Atashi","year":"2025","journal-title":"Nutr Diabetes"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1274335","DOI":"10.3389\/fphar.2023.1274335","volume":"14","author":"Wang","year":"2023","journal-title":"Front Pharmacol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"108726","DOI":"10.1016\/j.pharmthera.2024.108726","volume":"263","author":"Mangaonkar","year":"2024","journal-title":"Pharmacol Ther"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"13671","DOI":"10.1038\/s41598-025-97463-9","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci Rep"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1110104","DOI":"10.3389\/fonc.2022.1110104","volume":"12","author":"Costantini","year":"2023","journal-title":"Front Oncol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41416-025-02997-4","volume":"133","author":"Yuan","year":"2025","journal-title":"Br J Cancer"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s42003-019-0305-x","volume":"2","author":"Phan","year":"2019","journal-title":"Commun Biol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41563-021-01057-5","volume":"21","author":"LeSavage","year":"2022","journal-title":"Nat Mater"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13578-023-00977-w","volume":"13","author":"Zhang","year":"2023","journal-title":"Cell Biosci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1186\/s12885-021-08902-5","volume":"21","author":"Yang","year":"2021","journal-title":"BMC Cancer"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.3390\/cells10051056","volume":"10","author":"Schiliro","year":"2021","journal-title":"Cells"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fbioe.2016.00012","volume":"4","author":"Katt","year":"2016","journal-title":"Front Bioeng Biotechnol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1126\/science.aaw6985","volume":"364","author":"Tuveson","year":"2019","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1038\/nm.4438","volume":"23","author":"Broutier","year":"2017","journal-title":"Nat Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1126\/science.aao2774","volume":"359","author":"Vlachogiannis","year":"2018","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1136\/gutjnl-2017-314549","volume":"68","author":"Seidlitz","year":"2019","journal-title":"Gut"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.3390\/cancers12123636","volume":"12","author":"Vivarelli","year":"2020","journal-title":"Cancers"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"640863","DOI":"10.3389\/fonc.2021.640863","volume":"11","author":"Albahde","year":"2021","journal-title":"Front Oncol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00280-018-3714-5","volume":"83","author":"Murono","year":"2019","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1355566","DOI":"10.3389\/fimmu.2024.1355566","volume":"15","author":"Kim","year":"2024","journal-title":"Front Immunol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"816","DOI":"10.3390\/ph15070816","volume":"15","author":"El-Far","year":"2022","journal-title":"Pharmaceuticals"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"14984","DOI":"10.1038\/s41598-021-94399-8","volume":"11","author":"Masner","year":"2021","journal-title":"Sci Rep"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/114571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/114571","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:50:14Z","timestamp":1777301414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/linoleic-acid-reduces-paclitaxel-chemosensitivity-in-colorectal-cancer-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":46,"URL":"https:\/\/doi.org\/10.2147\/dddt.s577058","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}