{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:58:47Z","timestamp":1776689927996,"version":"3.51.2"},"reference-count":40,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s587387","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:35:12Z","timestamp":1776688512000},"page":"1-13","source":"Crossref","is-referenced-by-count":0,"title":["Population Pharmacokinetics of Tiapride in Children and Adolescents with Tic Disorders: Leveraging Plasma and Saliva Concentration to Guide Individualized Dosing"],"prefix":"10.2147","volume":"Volume 20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5272-5586","authenticated-orcid":true,"given":"Wei","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangrui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8169-9412","authenticated-orcid":true,"given":"You","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4971-8489","authenticated-orcid":true,"given":"Baohua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00787-018-1190-4","volume":"28","author":"Schrag","year":"2019","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/B978-0-444-64012-3.00008-3","volume":"165","author":"Deeb","year":"2019","journal-title":"Handb Clin Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.pediatrneurol.2012.05.002","volume":"47","author":"Knight","year":"2012","journal-title":"Pediatr Neurol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.jpsychores.2008.03.006","volume":"65","author":"Robertson","year":"2008","journal-title":"J Psychosom Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1469-8749.2002.tb00820.x","volume":"44","author":"Gadow","year":"2002","journal-title":"Dev Med Child Neurol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.3390\/jcm10112479","volume":"10","author":"Ueda","year":"2021","journal-title":"J Clin Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s00787-021-01899-z","volume":"31","author":"Roessner","year":"2022","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"774","DOI":"10.3389\/fpsyt.2020.00774","volume":"11","author":"Liu","year":"2020","journal-title":"Front Psychiatry"},{"key":"ref9","unstructured":"The Subspecialty Group of Neurology, the Society of Pediatrics, Chinese Medical Association. Experts consensus of treatment and diagnosis of tic disorders in children (2017 practical version). Chin J Appl Clin Pediatr. 2017;32(15):1137\u20131140. doi:10.3760\/cma.j.issn.2095-428X.2017.15.005"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1212\/WNL.0000000000007466","volume":"92","author":"Pringsheim","year":"2019","journal-title":"Neurology"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"455","DOI":"10.2165\/00044011-199815050-00010","volume":"15","author":"Canal","year":"1998","journal-title":"Clin Drug Invest"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1055\/s-2000-7964","volume":"33","author":"Dose","year":"2000","journal-title":"Pharmacopsychiatry"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1007\/s00228-021-03159-0","volume":"77","author":"Fekete","year":"2021","journal-title":"Eur J Clin Pharmacol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/BF00606657","volume":"31","author":"Roos","year":"1986","journal-title":"Eur J Clin Pharmacol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.pedn.2017.08.025","volume":"37","author":"Stoltz","year":"2017","journal-title":"J Pediatr Nurs"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/00007691-200302000-00009","volume":"25","author":"Grim","year":"2003","journal-title":"Ther Drug Monit"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1016\/j.clinthera.2021.10.012","volume":"43","author":"Ashraf","year":"2021","journal-title":"Clin Ther"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.32383\/appdr\/186004","volume":"81","author":"Kuczy\u0144ska","year":"2024","journal-title":"Acta Poloniae Pharmaceutica Drug Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1097\/00007691-199402000-00010","volume":"16","author":"Kirk","year":"1994","journal-title":"Ther Drug Monit"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.3390\/molecules24162953","volume":"24","author":"Dziurkowska","year":"2019","journal-title":"Molecules"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1365-2125.1993.tb05700.x","volume":"35","author":"Chee","year":"1993","journal-title":"Br J Clin Pharmacol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.clinbiochem.2021.11.008","volume":"100","author":"Cossart","year":"2022","journal-title":"Clin Biochem"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1111\/bcp.15105","volume":"88","author":"Samb","year":"2022","journal-title":"Br J Clin Pharmacol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1111\/bcp.15152","volume":"88","author":"Kruizinga","year":"2022","journal-title":"Br J Clin Pharmacol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1002\/psp4.13004","volume":"12","author":"Xu","year":"2023","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1097\/NMD.0b013e3182a2168a","volume":"201","author":"First","year":"2013","journal-title":"J Nerv Ment Dis"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3845","DOI":"10.1016\/j.jchromb.2011.10.032","volume":"879","author":"Nobilis","year":"2011","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1248\/bpb.b15-00030","volume":"38","author":"Tsuji","year":"2015","journal-title":"Biol Pharm Bull"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1002\/psp4.13205","volume":"13","author":"Khaowroongrueng","year":"2024","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1002\/cpdd.1477","volume":"13","author":"Liu","year":"2024","journal-title":"Clin Pharmacol Drug Dev"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1038\/s41401-022-00892-9","volume":"43","author":"Liu","year":"2022","journal-title":"Acta Pharmacol Sin"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1111\/bcp.15823","volume":"89","author":"Samb","year":"2023","journal-title":"Br J Clin Pharmacol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.cmpb.2016.02.001","volume":"127","author":"Aoki","year":"2016","journal-title":"Comput Methods Programs Biomed"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1023\/a:1012299115260","volume":"28","author":"Beal","year":"2001","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"ref35","first-page":"62","volume":"20","author":"Rey","year":"1982","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/BF02455992","volume":"32","author":"Norman","year":"1987","journal-title":"Eur J Clin Pharmacol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.2165\/00003495-199447060-00009","volume":"47","author":"Peters","year":"1994","journal-title":"Drugs"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1002\/j.1875-9114.2012.01108.x","volume":"32","author":"Pai","year":"2012","journal-title":"Pharmacotherapy"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"5622","DOI":"10.3390\/ijms26125622","volume":"26","author":"Monserrat-Mesquida","year":"2025","journal-title":"Int J Mol Sci"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1515\/dmdi.2009.24.2-4.259","volume":"24","author":"Mahmood","year":"2009","journal-title":"Drug Metabol Drug Interact"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/114284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/114284","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:35:16Z","timestamp":1776688516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/population-pharmacokinetics-of-tiapride-in-children-and-adolescents-wi-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":40,"URL":"https:\/\/doi.org\/10.2147\/dddt.s587387","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}