{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:19:55Z","timestamp":1789150795621,"version":"build-2803163510"},"reference-count":39,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s595458","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:50:12Z","timestamp":1770137412000},"page":"1-12","source":"Crossref","is-referenced-by-count":2,"title":["ED95 of Ciprofol Combined with Esketamine or Sufentanil in Elderly Patients Undergoing Endoscopic Submucosal Dissection: A Dose-Finding and Randomized Controlled Trial"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Xiaoxue","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9727-0359","authenticated-orcid":true,"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaodan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyar","family":"Mamtili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.gie.2023.03.030","volume":"98","author":"Al-Haddad","year":"2023","journal-title":"Gastrointest Endosc"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.gie.2023.03.015","volume":"98","author":"Forbes","year":"2023","journal-title":"Gastrointest Endosc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s12876-017-0692-8","volume":"17","author":"Yamaguchi","year":"2017","journal-title":"BMC Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"8195","DOI":"10.3748\/wjg.v21.i26.8195","volume":"21","author":"Takada","year":"2015","journal-title":"World J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1136\/gutjnl-2023-330396corr1","volume":"73","author":"Sidhu","year":"2024","journal-title":"Gut"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e70045","DOI":"10.1002\/deo2.70045","volume":"5","author":"Ishido","year":"2024","journal-title":"DEN Open"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1101\/2024.11.14.24317324","volume":"1","author":"Abosheaishaa","year":"2025","journal-title":"ASIDE Gastroenterol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"111047","DOI":"10.1016\/j.jclinane.2022.111047","volume":"85","author":"Zhong","year":"2023","journal-title":"J Clin Anesth"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1412726","DOI":"10.3389\/fphar.2024.1412726","volume":"15","author":"Huang","year":"2024","journal-title":"Front Pharmacol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ajem.2023.04.020","volume":"70","author":"Hutchings","year":"2023","journal-title":"Am J Emerg Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"7443226","DOI":"10.1155\/2023\/7443226","volume":"2023","author":"Lu","year":"2023","journal-title":"Biomed Res Int"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"103307","DOI":"10.1016\/j.eclinm.2025.103307","volume":"85","author":"Li","year":"2025","journal-title":"EClinicalMedicine"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1002\/lary.30699","volume":"133","author":"Zhang","year":"2023","journal-title":"Laryngoscope"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.psc.2023.02.003","volume":"46","author":"Feeney","year":"2023","journal-title":"Psychiatr Clin North Am"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/ibra.12019","volume":"8","author":"Zhang","year":"2022","journal-title":"Ibrain"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1287761","DOI":"10.3389\/fphar.2024.1287761","volume":"15","author":"Kan","year":"2024","journal-title":"Front Pharmacol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s12871-023-02135-8","volume":"23","author":"Chen","year":"2023","journal-title":"BMC Anesthesiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/LBR.0000000000000784","volume":"29","author":"Pastis","year":"2022","journal-title":"J Bronchology Interv Pulmonol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"15593258241248931","DOI":"10.1177\/15593258241248931","volume":"22","author":"Xiong","year":"2024","journal-title":"Dose Response"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/01.anes.0000267514.42592.2a","volume":"107","author":"Pace","year":"2007","journal-title":"Anesthesiology"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/s0149-7634(05)80090-9","volume":"15","author":"Dixon","year":"1991","journal-title":"Neurosci Biobehav Rev"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1093\/bja\/aer195","volume":"107","author":"Gerbershagen","year":"2011","journal-title":"Br J Anaesth"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1186\/s12876-022-02549-7","volume":"22","author":"Yamaguchi","year":"2022","journal-title":"BMC Gastroenterol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e68034","DOI":"10.7759\/cureus.68034","volume":"16","author":"Petkar","year":"2024","journal-title":"Cureus"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s44158-024-00159-1","volume":"4","author":"Curr\u00f2","year":"2024","journal-title":"J Anesth Analg Crit Care"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e57581","DOI":"10.7759\/cureus.57581","volume":"16","author":"Durai Samy","year":"2024","journal-title":"Cureus"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/bcpt.13761","volume":"131","author":"Li","year":"2022","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1213\/ANE.0000000000006851","volume":"139","author":"Mion","year":"2024","journal-title":"Anesth Analg"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.bja.2024.11.011","volume":"134","author":"Suleiman","year":"2025","journal-title":"Br J Anaesth"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e2347886","DOI":"10.1001\/jamanetworkopen.2023.47886","volume":"6","author":"Song","year":"2023","journal-title":"JAMA Network Open"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1111\/bcp.15072","volume":"88","author":"Yang","year":"2022","journal-title":"Br J Clin Pharmacol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3629","DOI":"10.2147\/DDDT.S472651","volume":"18","author":"Weng","year":"2024","journal-title":"Drug Des Devel Ther"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.bja.2018.02.021","volume":"120","author":"Jonkman","year":"2018","journal-title":"Br J Anaesth"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"214","DOI":"10.23736\/S0375-9393.23.17686-3","volume":"90","author":"Chen","year":"2024","journal-title":"Minerva Anestesiol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"5269","DOI":"10.2147\/DDDT.S490179","volume":"18","author":"Deng","year":"2024","journal-title":"Drug Des Devel Ther"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"103997","DOI":"10.1016\/j.ajp.2024.103997","volume":"95","author":"Lou","year":"2024","journal-title":"Asian J Psychiatr"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12871-024-02424-w","volume":"24","author":"Liu","year":"2024","journal-title":"BMC Anesthesiol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"863","DOI":"10.2147\/DDDT.S401161","volume":"17","author":"Han","year":"2023","journal-title":"Drug Des Devel Ther"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1186\/s12871-024-02803-3","volume":"24","author":"Lin","year":"2024","journal-title":"BMC Anesthesiol"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/111644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/111644","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:50:13Z","timestamp":1770137413000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/ed95-of-ciprofol-combined-with-esketamine-or-sufentanil-in-elderly-pat-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":39,"URL":"https:\/\/doi.org\/10.2147\/dddt.s595458","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]}}}