{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:13:13Z","timestamp":1791922393448,"version":"4.3.4"},"reference-count":105,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s597046","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:45:36Z","timestamp":1778514336000},"page":"1-17","source":"Crossref","is-referenced-by-count":2,"title":["Development Trends of Janus Kinase Inhibitors (JAKi) Over Three Decades: From Common to Rare Diseases"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Rui","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/s41392-024-01934-w","volume":"9","author":"Lv","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e13688","DOI":"10.1111\/cts.13688","volume":"17","author":"Mohamed","year":"2024","journal-title":"Clin Transl Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3857","DOI":"10.1016\/j.cell.2022.09.023","volume":"185","author":"Philips","year":"2022","journal-title":"Cell"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/nrrheum.2017.51","volume":"13","author":"Winthrop","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1699928","DOI":"10.3389\/fphar.2025.1699928","volume":"16","author":"Wu","year":"2025","journal-title":"Front Pharmacol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e00537","DOI":"10.1002\/prp2.537","volume":"7","author":"Dowty","year":"2019","journal-title":"Pharmacol Res Perspect"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/17512433.2025.2576698","volume":"18","author":"Tachet","year":"2025","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref8","unstructured":"New Drug Application review report of Ruxolitinib (Jakavi\u00ae) source of Drugs@FDA: FDA-Approved Drugs. Available from: https:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/index.cfm. Accessed January 26, 2026."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.jaci.2021.08.004","volume":"148","author":"Luo","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"104568","DOI":"10.1016\/j.drudis.2025.104568","volume":"31","author":"Parker","year":"2026","journal-title":"Drug Discov Today"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"3442","DOI":"10.1021\/acschembio.6b00677","volume":"11","author":"Telliez","year":"2016","journal-title":"ACS Chem Biol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"107712","DOI":"10.1016\/j.compbiolchem.2022.107712","volume":"99","author":"Xie","year":"2022","journal-title":"Comput Biol Chem"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e59978","DOI":"10.7759\/cureus.59978","volume":"16","author":"Potlabathini","year":"2024","journal-title":"Cureus"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"125789","DOI":"10.1016\/j.ijpharm.2025.125789","volume":"680","author":"Jarallah","year":"2025","journal-title":"Int J Pharm"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.jaad.2025.05.1385","volume":"93","author":"Eichenfield","year":"2025","journal-title":"J Am Acad Dermatol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.resinv.2025.07.011","volume":"63","author":"Itagaki","year":"2025","journal-title":"Respir Investig"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1002\/hon.2537","volume":"36","author":"Mughal","year":"2018","journal-title":"Hematol Oncol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1080\/14737167.2025.2507426","volume":"25","author":"Williamson","year":"2025","journal-title":"Expert Rev Pharmacoecon Outcomes Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/d41573-025-00102-1","volume":"24","author":"Liu","year":"2025","journal-title":"Nat Rev Drug Discov"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/nrd.2018.150","volume":"17","author":"Xu","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"ref22","unstructured":"Clinical trial registration of Baricitinib in website of clinicaltrials.gov. Available from: https:\/\/clinicaltrials.gov\/search?term=baricitinib&aggFilters=phase:3%204&viewType=Table. Accessed January 26, 2026."},{"key":"ref23","unstructured":"Drugs@FDA: FDA-Approved Drugs for Baricitinib. Available from: https:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/index.cfm?event=BasicSearch.process. Accessed January 26, 2026."},{"key":"ref24","unstructured":"Marketing authorisation issued for Baricitinib in European Medicines Agency. Available from: https:\/\/www.ema.europa.eu\/en\/medicines. Accessed January 26, 2026."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/s0140-6736(22)02546-6","volume":"401","author":"Petri","year":"2023","journal-title":"Lancet"},{"key":"ref26","unstructured":"FDA requires warnings about increased risk of serious heart-related events, cancer, blood clots, and death for JAK inhibitors that treat certain chronic inflammatory conditions: Drug Safety Communications in 2021 in FDA. Available from: https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-requires-warnings-about-increased-risk-serious-heart-related-events-cancer-blood-clots-and-death. Accessed January 26, 2026."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1007\/s40265-025-02202-z","volume":"85","author":"Keam","year":"2025","journal-title":"Drugs"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e70185","DOI":"10.1111\/jocd.70185","volume":"24","author":"Gupta","year":"2025","journal-title":"J Cosmet Dermatol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.12968\/hmed.2024.0798","volume":"86","author":"Eden","year":"2025","journal-title":"Br J Hosp Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/s40265-024-02089-2","volume":"84","author":"Keam","year":"2024","journal-title":"Drugs"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"568","DOI":"10.3390\/cancers17040568","volume":"17","author":"Kashyap","year":"2025","journal-title":"Cancers"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1038\/s44321-025-00317-0","volume":"17","author":"Jeanpierre","year":"2025","journal-title":"EMBO Mol Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41392-023-01468-7","volume":"8","author":"Xue","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e123","DOI":"10.1182\/blood-2014-02-554634","volume":"123","author":"Rampal","year":"2014","journal-title":"Blood"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"178032","DOI":"10.1016\/j.ejphar.2025.178032","volume":"1005","author":"Hong","year":"2025","journal-title":"Eur J Pharmacol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s10637-019-00812-5","volume":"38","author":"Machado-Neto","year":"2020","journal-title":"Invest New Drugs"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/ajh.27658","volume":"100","author":"Loscocco","year":"2025","journal-title":"Am J Hematol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/ajh.24976","volume":"93","author":"Lussana","year":"2018","journal-title":"Am J Hematol"},{"key":"ref39","first-page":"2415","volume":"9","author":"Rane","year":"1994","journal-title":"Oncogene"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e010783","DOI":"10.1136\/jitc-2024-010783","volume":"13","author":"Lou","year":"2025","journal-title":"J Immunother Cancer"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s40265-019-01131-y","volume":"79","author":"Markham","year":"2019","journal-title":"Drugs"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1093\/ced\/llaf194","volume":"50","author":"Dai","year":"2025","journal-title":"Clin Exp Dermatol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/art.38949","volume":"67","author":"Fleischmann","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"eaaw1736","DOI":"10.1126\/scitranslmed.aaw1736","volume":"11","author":"Burke","year":"2019","journal-title":"Sci Transl Med"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1093\/bjd\/ljad473","volume":"190","author":"Gu\u00e9nin","year":"2024","journal-title":"Br J Dermatol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1111\/1346-8138.17834","volume":"52","author":"Zhang","year":"2025","journal-title":"J Dermatol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"884399","DOI":"10.3389\/fimmu.2022.884399","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Immunol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"8951","DOI":"10.1021\/acs.jmedchem.9b01612","volume":"62","author":"Chang","year":"2019","journal-title":"J Med Chem"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/s0092-8674(00)81168-x","volume":"93","author":"Neubauer","year":"1998","journal-title":"Cell"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"114551","DOI":"10.1016\/j.ejmech.2022.114551","volume":"239","author":"Shen","year":"2022","journal-title":"Eur J Med Chem"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/sji.12069","volume":"78","author":"Vargas","year":"2013","journal-title":"Scand J Immunol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41573-020-0082-8","volume":"20","author":"Zarrin","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"C1231","DOI":"10.1152\/ajpcell.00040.2022","volume":"323","author":"Zheng","year":"2022","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.drudis.2010.05.001","volume":"15","author":"Riccaboni","year":"2010","journal-title":"Drug Discov Today"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1038\/leu.2012.24","volume":"26","author":"Hoellenriegel","year":"2012","journal-title":"Leukemia"},{"key":"ref56","unstructured":"CSPC Pharmaceutical Group Co. Ltd. Available from: https:\/\/www.e-cspc.com\/development\/index.html. Accessed January 26, 2026."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.ard.2025.01.032","volume":"84","author":"Nash","year":"2025","journal-title":"Ann Rheum Dis"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.ard.2025.01.023","volume":"84","author":"Konzett","year":"2025","journal-title":"Ann Rheum Dis"},{"key":"ref59","unstructured":"International Classification of Disease 11th revision (ICD-11). World Health Organization. Available from: https:\/\/www.who.int\/standards\/classifications\/classification-of-diseases. Accessed January 26, 2026."},{"key":"ref60","unstructured":"Orphanet database. Available from: https:\/\/www.orpha.net\/. Accessed January 26, 2026."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"251","DOI":"10.5582\/irdr.2023.01086","volume":"12","author":"Tang","year":"2023","journal-title":"Intractable Rare Dis Res"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2479126","DOI":"10.1080\/09546634.2025.2479126","volume":"36","author":"Abdelhalim","year":"2025","journal-title":"J Dermatol Treat"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.jaad.2021.07.002","volume":"86","author":"Chapman","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/j.jaad.2020.02.009","volume":"82","author":"Kim","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"103276","DOI":"10.1016\/j.autrev.2023.103276","volume":"22","author":"Benucci","year":"2023","journal-title":"Autoimmun Rev"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"152572","DOI":"10.1016\/j.semarthrit.2024.152572","volume":"69","author":"Al Tabaa","year":"2024","journal-title":"Semin Arthritis Rheum"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1136\/annrheumdis-2020-218398","volume":"80","author":"Nash","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"e70207","DOI":"10.1002\/mco2.70207","volume":"6","author":"Zhang","year":"2025","journal-title":"MedComm"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"107028","DOI":"10.1016\/j.intimp.2020.107028","volume":"89","author":"Luo","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1675350","DOI":"10.3389\/fimmu.2025.1675350","volume":"16","author":"Szebeni","year":"2025","journal-title":"Front Immunol"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"11788","DOI":"10.3390\/ijms231911788","volume":"23","author":"Richter","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"8555","DOI":"10.1073\/pnas.87.21.8555","volume":"87","author":"Fu","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/s41577-021-00633-9","volume":"22","author":"Crow","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1749-6632.2011.06220.x","volume":"1238","author":"Crow","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12969-023-00817-8","volume":"21","author":"Kanazawa","year":"2023","journal-title":"Pediatr Rheumatol Online J"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ymgme.2022.06.003","volume":"136","author":"Adang","year":"2022","journal-title":"Mol Genet Metab"},{"key":"ref77","unstructured":"FDA. E11A Pediatric Extrapolation Guidance for Industry. 2024. Available from: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/e11a-pediatric-extrapolation. Accessed January 26, 2026."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1534\/g3.117.044172","volume":"7","author":"Anderson","year":"2017","journal-title":"G3"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"487","DOI":"10.2174\/1389450117666161207163054","volume":"19","author":"Gao","year":"2018","journal-title":"Curr Drug Targets"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"D941","DOI":"10.1093\/nar\/gky1015","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1038\/s41375-022-01544-x","volume":"36","author":"England","year":"2022","journal-title":"Leukemia"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"e482","DOI":"10.3324\/haematol.2016.151449","volume":"101","author":"Gupta","year":"2016","journal-title":"Haematologica"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.cmet.2019.10.013","volume":"31","author":"Zhang","year":"2020","journal-title":"Cell Metab"},{"key":"ref85","unstructured":"Clinical development success rates and contributing factors 2011\u20132020. Biotechnology Innovation Organization. Available from: https:\/\/www.bio.org\/clinical-development-success-rates-and-contributing-factors-2011-2020. Accessed January 26, 2026."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1002\/ajh.27245","volume":"99","author":"Zhang","year":"2024","journal-title":"Am J Hematol"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/ejh.14321","volume":"114","author":"Ajufo","year":"2025","journal-title":"Eur J Haematol"},{"key":"ref88","unstructured":"FDA orphan drug designation and approved. Available from: https:\/\/www.accessdata.fda.gov\/scripts\/opdlisting\/oopd\/listResult.cfm. Accessed January 26, 2026."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"4938","DOI":"10.3390\/jcm14144938","volume":"14","author":"Marszk","year":"2025","journal-title":"J Clin Med"},{"key":"ref90","unstructured":"PopulationPyramid.net. Available from: https:\/\/www.populationpyramid.net\/. Accessed January 26, 2026."},{"key":"ref91","unstructured":"Code of Federal Regulations (CFR) of United States: 21-CFR Part 316 \u201cOrphan Drugs\u201d- 316.31 Scope of orphan-drug exclusive approval. Available from: https:\/\/www.ecfr.gov\/current\/title-21\/section-316.31. Accessed January 26, 2026."},{"key":"ref92","unstructured":"European Commission. Guideline on the format and content of applications for designation as orphan medicinal products and on the transfer of designations from one sponsor to another. 2022. Available from: https:\/\/health.ec.europa.eu\/system\/files\/2021-12\/2021-07_guideline_rev5_en.pdf. Accessed January 26, 2026."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1182\/blood.2024026581","volume":"145","author":"Zhao","year":"2025","journal-title":"Blood"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"e63978","DOI":"10.1002\/ajmg.a.63978","volume":"197","author":"Spracklen","year":"2025","journal-title":"Am J Med Genet A"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1038\/s41375-018-0028-x","volume":"32","author":"Nicolosi","year":"2018","journal-title":"Leukemia"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/d41573-024-00001-x","volume":"23","author":"Mullard","year":"2024","journal-title":"Nat Rev Drug Discov"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"123917","DOI":"10.1016\/j.jchromb.2023.123917","volume":"1230","author":"Tachet","year":"2023","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/cpdd.71","volume":"3","author":"Gupta","year":"2014","journal-title":"Clin Pharmacol Drug Dev"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1124\/dmd.117.078899","volume":"46","author":"Zheng","year":"2018","journal-title":"Drug Metab Dispos"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"101030","DOI":"10.1016\/j.dmpk.2024.101030","volume":"59","author":"Zhao","year":"2024","journal-title":"Drug Metab Pharmacokinet"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.2217\/fon.11.81","volume":"7","author":"Ostojic","year":"2011","journal-title":"Future Oncol"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"5","DOI":"10.14712\/23362936.2023.1","volume":"124","author":"Stefanis","year":"2023","journal-title":"Prague Med Rep"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1124\/dmd.110.033787","volume":"38","author":"Shilling","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.1111\/bcp.15803","volume":"89","author":"Ismail","year":"2023","journal-title":"Br J Clin Pharmacol"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"e70295","DOI":"10.1111\/cts.70295","volume":"18","author":"Bhatnagar","year":"2025","journal-title":"Clin Transl Sci"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115050","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:45:45Z","timestamp":1778514345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/development-trends-of-janus-kinase-inhibitors-jaki-over-three-decades--peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":105,"URL":"https:\/\/doi.org\/10.2147\/dddt.s597046","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}