{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:33:18Z","timestamp":1788805998908,"version":"build-2803163510"},"reference-count":57,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s599941","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:45:26Z","timestamp":1778759126000},"page":"1-16","source":"Crossref","is-referenced-by-count":1,"title":["DAPT Mitigates Osteoarthritic Cartilage Degeneration and Enhances Articular Repair Through Targeted Modulation of the Gucy1a3 and Notch Signaling Axis"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Xiaoyan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-5852","authenticated-orcid":true,"given":"Rui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11926-007-0016-z","volume":"9","author":"Scher","year":"2007","journal-title":"Curr Rheumatol Rep"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1002\/jor.22954","volume":"33","author":"Santoro","year":"2015","journal-title":"J Orthopaedic Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.freeradbiomed.2016.02.026","volume":"94","author":"Quan","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"8922021","DOI":"10.1155\/2022\/8922021","volume":"2022","author":"Yu","year":"2022","journal-title":"Evidence Based Complement Alternat Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"5233462","DOI":"10.1155\/2021\/5233462","volume":"2021","author":"Chen","year":"2021","journal-title":"Evidence Based Complement Alternat Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222112012","volume":"22","author":"Minguzzi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41392-022-00934-y","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduction Targeted Ther"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"ra71","DOI":"10.1126\/scisignal.aaa3792","volume":"8","author":"Liu","year":"2015","journal-title":"Sci Signaling"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3109\/10799893.2013.856920","volume":"34","author":"Sassi","year":"2014","journal-title":"J Receptor Signal Transduction Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1073\/pnas.1207458110","volume":"110","author":"Hosaka","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1053\/j.gastro.2005.01.055","volume":"128","author":"Ishimura","year":"2005","journal-title":"Gastroenterology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e70203","DOI":"10.1111\/jcmm.70203","volume":"28","author":"Zhang","year":"2024","journal-title":"J Cell Mol Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.stem.2010.01.001","volume":"6","author":"Charles","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.cell.2009.03.045","volume":"137","author":"Kopan","year":"2009","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1038\/s41598-017-01392-1","volume":"7","author":"Rippe","year":"2017","journal-title":"Sci Rep"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"8989","DOI":"10.1038\/ncomms9989","volume":"6","author":"Kessler","year":"2015","journal-title":"Nat Commun"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/s41419-025-07470-x","volume":"16","author":"Yan","year":"2025","journal-title":"Cell Death Dis"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1161\/circresaha.122.322298","volume":"132","author":"Kosmac","year":"2023","journal-title":"Circul Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1002\/ejhf.2720","volume":"24","author":"Butler","year":"2022","journal-title":"Eur J Heart Failure"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nrd4252","volume":"13","author":"Andersson","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"346","DOI":"10.30802\/aalas-jaalas-19-000081","volume":"59","author":"Pang","year":"2020","journal-title":"J Am Assoc Lab Animal Sci"},{"key":"ref22","unstructured":"American Veterinary Medical Association. AVMA Guidelines for the Euthanasia of Animals: 2020 Edition. 2020. Available from: https:\/\/www.avma.org\/sites\/default\/files\/2020-02\/Guidelines-on-Euthanasia-2020.pdf. Accessed May 08, 2026."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"3036","DOI":"10.1111\/os.13496","volume":"14","author":"Wang","year":"2022","journal-title":"Orthopaedic Surg"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1007\/s13770-022-00488-8","volume":"19","author":"Go","year":"2022","journal-title":"Tissue Eng Regen Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"100837","DOI":"10.1016\/j.diff.2025.100837","volume":"142","author":"Resuela-Gonz\u00e1lez","year":"2025","journal-title":"Different Res Biol Divers"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.2147\/dddt.S377001","volume":"16","author":"Rong","year":"2022","journal-title":"Drug Des Devel Ther"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.3892\/ijmm.2015.2168","volume":"35","author":"Ni","year":"2015","journal-title":"IntJ Mol Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"3200","DOI":"10.1172\/jci68901","volume":"124","author":"Zhang","year":"2014","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nrrheum.2010.197","volume":"7","author":"Lories","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"172794","DOI":"10.1016\/j.ejphar.2019.172794","volume":"865","author":"Xu","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1002\/jbmr.3117","volume":"32","author":"Sun","year":"2017","journal-title":"J Bone Mineral Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"103302","DOI":"10.1016\/j.tice.2025.103302","volume":"99","author":"Chen","year":"2026","journal-title":"Tissue Cell"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28020814","volume":"28","author":"Fujii","year":"2023","journal-title":"Molecules"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"802336","DOI":"10.3389\/fimmu.2022.802336","volume":"13","author":"Abramowitz","year":"2022","journal-title":"Front Immunol"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262412056","volume":"26","author":"Kang","year":"2025","journal-title":"Int J Mol Sci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1164137","DOI":"10.3389\/fimmu.2023.1164137","volume":"14","author":"Zhao","year":"2023","journal-title":"Front Immunol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"532","DOI":"10.3389\/fimmu.2014.00532","volume":"5","author":"Rath","year":"2014","journal-title":"Front Immunol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.yjmcc.2013.04.001","volume":"60","author":"Bosse","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1002\/art.38076","volume":"65","author":"Mirando","year":"2013","journal-title":"Arthritis Rheum"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.joca.2015.10.015","volume":"24","author":"Liu","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"3080","DOI":"10.1073\/pnas.1419699112","volume":"112","author":"Sugita","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"703110","DOI":"10.3389\/fmolb.2021.703110","volume":"8","author":"Jiang","year":"2021","journal-title":"Front Mol Biosci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s13075-017-1296-y","volume":"19","author":"Saito","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s13075-023-03039-1","volume":"25","author":"Wang","year":"2023","journal-title":"Arthritis Res Ther"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.tcb.2012.02.003","volume":"22","author":"Andersen","year":"2012","journal-title":"Trends Cell Biol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s13578-021-00599-0","volume":"11","author":"Cheng","year":"2021","journal-title":"Cell Biosci"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"11007","DOI":"10.1080\/21655979.2021.2005220","volume":"12","author":"Yang","year":"2021","journal-title":"Bioengineered"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"28431","DOI":"10.18632\/oncotarget.16085","volume":"8","author":"Shu","year":"2017","journal-title":"Oncotarget"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"114627","DOI":"10.1016\/j.biopha.2023.114627","volume":"162","author":"Estupi\u00f1\u00e1n","year":"2023","journal-title":"Biomed Pharmacothe"},{"key":"ref50","first-page":"2933","volume":"9","author":"Ji","year":"2017","journal-title":"Am J Transl Res"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/nm1716","volume":"14","author":"Hilton","year":"2008","journal-title":"Nat Med"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087389","volume":"24","author":"Uribe-Etxebarria","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13619-020-00072-2","volume":"10","author":"Gao","year":"2021","journal-title":"Cell Regen"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s11670-011-0140-1","volume":"23","author":"Jiang","year":"2011","journal-title":"Chin J Cancer Res"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1002\/jcb.25196","volume":"116","author":"Fender","year":"2015","journal-title":"J Cell Biochem"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nrrheum.2016.210","volume":"13","author":"Bajpayee","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"124843","DOI":"10.1016\/j.ijpharm.2024.124843","volume":"666","author":"Morici","year":"2024","journal-title":"Int J Pharm"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115172","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:45:29Z","timestamp":1778759129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/dapt-mitigates-osteoarthritic-cartilage-degeneration-and-enhances-arti-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":57,"URL":"https:\/\/doi.org\/10.2147\/dddt.s599941","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}