{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:08:33Z","timestamp":1779120513047,"version":"3.51.4"},"reference-count":29,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s601178","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:20:14Z","timestamp":1779117614000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["The ED90 of Oliceridine for Tracheal Intubation in Children: A Biased-Coin Up-and-Down Parallel Dose-Finding Study"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Liqun","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingzhi","family":"Dan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-9557","authenticated-orcid":true,"given":"Jijian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7656-8952","authenticated-orcid":true,"given":"Kan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"CD004087","DOI":"10.1002\/14651858.CD004087.pub2","volume":"2013","author":"Khan","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaz3140","volume":"13","author":"Gillis","year":"2020","journal-title":"Sci Signal"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"4361","DOI":"10.1016\/j.cell.2022.09.041","volume":"185","author":"Zhuang","year":"2022","journal-title":"Cell"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1111\/bph.15409","volume":"178","author":"Singleton","year":"2021","journal-title":"Br J Pharmacol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.giec.2022.10.001","volume":"33","author":"Mahoney","year":"2023","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1002\/jpn3.12284","volume":"79","author":"Schneck","year":"2024","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s00210-025-04557-2","volume":"399","author":"Elrosasy","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref8","unstructured":"U.S. Food & Drug Administration. FDA approves new opioid for intravenous use in hospitals, other controlled clinical settings. 2020 Available from: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-new-opioid-intravenous-use-hospitals-other-controlled-clinical-settings. Accessed May 12, 2026."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"875","DOI":"10.2147\/DDDT.S372612","volume":"17","author":"Daksla","year":"2023","journal-title":"Drug Des Devel Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"349","DOI":"10.4103\/sja.SJA_813_19","volume":"14","author":"Goudra","year":"2020","journal-title":"Saudi J Anaesth"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1097\/ALN.0000000000004758","volume":"139","author":"Moss","year":"2023","journal-title":"Anesthesiology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1097\/ALN.0000000000004473","volume":"138","author":"Simons","year":"2023","journal-title":"Anesthesiology"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1124\/jpet.112.201616","volume":"344","author":"DeWire","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/01.anes.0000267514.42592.2a","volume":"107","author":"Pace","year":"2007","journal-title":"Anesthesiology"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/ALN.0000000000004282","volume":"137","author":"Oron","year":"2022","journal-title":"Anesthesiology"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"11767","DOI":"10.2147\/DDDT.S567868","volume":"19","author":"Yu","year":"2025","journal-title":"Drug Des Devel Ther"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"10259","DOI":"10.2147\/DDDT.S549813","volume":"19","author":"Xu","year":"2025","journal-title":"Drug Des Devel Ther"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s12871-025-03052-8","volume":"25","author":"Tang","year":"2025","journal-title":"BMC Anesthesiol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"8879","DOI":"10.2147\/DDDT.S535435","volume":"19","author":"Wu","year":"2025","journal-title":"Drug Des Devel Ther"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"9343","DOI":"10.2147\/DDDT.S546489","volume":"19","author":"Song","year":"2025","journal-title":"Drug Des Devel Ther"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1093\/bja\/aen032","volume":"100","author":"Xue","year":"2008","journal-title":"Br J Anaesth"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1111\/j.1460-9592.2006.02162.x","volume":"17","author":"Xue","year":"2007","journal-title":"Paediatr Anaesth"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1016\/j.pain.2014.06.011","volume":"155","author":"Soergel","year":"2014","journal-title":"Pain"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1097\/j.pain.0000000000000363","volume":"157","author":"Viscusi","year":"2016","journal-title":"Pain"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.2147\/JPR.S137952","volume":"10","author":"Singla","year":"2017","journal-title":"J Pain Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1002\/jcph.207","volume":"54","author":"Soergel","year":"2014","journal-title":"J Clin Pharmacol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.2147\/JPR.S217563","volume":"12","author":"Bergese","year":"2019","journal-title":"J Pain Res"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1111\/papr.12801","volume":"19","author":"Singla","year":"2019","journal-title":"Pain Pract"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"927","DOI":"10.2147\/JPR.S171013","volume":"12","author":"Viscusi","year":"2019","journal-title":"J Pain Res"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115327","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:20:15Z","timestamp":1779117615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-ed90-of-oliceridine-for-tracheal-intubation-in-children-a-biased-c-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":29,"URL":"https:\/\/doi.org\/10.2147\/dddt.s601178","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}