{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:11:45Z","timestamp":1780420305108,"version":"3.54.1"},"reference-count":43,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s601238","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:40:25Z","timestamp":1780418425000},"page":"1-17","source":"Crossref","is-referenced-by-count":0,"title":["Optimizing Mirtazapine Initial Dosing: A Population Analysis of the Effects of BMI, Paroxetine and Fluvoxamine"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Hui","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4061-2944","authenticated-orcid":true,"given":"Wanting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5557-9951","authenticated-orcid":true,"given":"Yuqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewei","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2165\/00023210-200923050-00006","volume":"23","author":"Croom","year":"2009","journal-title":"CNS Drugs"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1007\/s00210-025-04525-w","volume":"399","author":"Mehra","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12888-024-06396-6","volume":"25","author":"Kamp","year":"2025","journal-title":"BMC Psychiatry"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e474","DOI":"10.3399\/BJGP.2024.0173","volume":"75","author":"Bakker","year":"2025","journal-title":"Br J Gen Pract"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"afaf050","DOI":"10.1093\/ageing\/afaf050","volume":"54","author":"Nguyen","year":"2025","journal-title":"Age Ageing"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/j.pnpbp.2010.07.028","volume":"35","author":"Monteleone","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psych"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1588902","DOI":"10.3389\/fpsyt.2025.1588902","volume":"16","author":"Fiorillo","year":"2025","journal-title":"Front Psychiatry"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1177\/02698811251337387","volume":"39","author":"Scherf-Clavel","year":"2025","journal-title":"J Psychopharmacol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1007\/s00228-025-03907-6","volume":"81","author":"Nierychlewski","year":"2025","journal-title":"Eur J Clin Pharmacol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1055\/s-0034-1383655","volume":"47","author":"Myung","year":"2014","journal-title":"Pharmacopsychiatry"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1345\/aph.1A014","volume":"35","author":"Anttila","year":"2001","journal-title":"Ann Pharmacother"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1345\/aph.10418","volume":"35","author":"Demers","year":"2001","journal-title":"Ann Pharmacother"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00228-004-0737-0","volume":"60","author":"Grasm\u00e4der","year":"2004","journal-title":"Eur J Clin Pharmacol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1080\/13651501.2024.2409654","volume":"28","author":"De Donatis","year":"2024","journal-title":"Int J Psychiatry Clin Pract"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1055\/s-0037-1600991","volume":"51","author":"Hiemke","year":"2018","journal-title":"Pharmacopsychiatry"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1001\/jama.2023.19897","volume":"330","author":"Elmaleh-Sachs","year":"2023","journal-title":"JAMA"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000547983","volume":"85","author":"Alam","year":"2026","journal-title":"Neuropsychobiology"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.jad.2020.11.059","volume":"281","author":"Xiao","year":"2021","journal-title":"J Affect Disord"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1055\/a-0918-6408","volume":"52","author":"Shinozaki","year":"2019","journal-title":"Pharmacopsychiatry"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/FTD.0b013e31819114ea","volume":"31","author":"Reis","year":"2009","journal-title":"Therapeutic Drug Monitor"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/FTD.0000000000000812","volume":"43","author":"Warrings","year":"2021","journal-title":"Therapeutic Drug Monitor"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1055\/s-2005-864120","volume":"38","author":"Grasm\u00e4der","year":"2005","journal-title":"Pharmacopsychiatry"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1080\/15622970701849978","volume":"10","author":"Sch\u00fcle","year":"2009","journal-title":"World J Biol Psychiatry"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1097\/00007691-200402000-00015","volume":"26","author":"Shams","year":"2004","journal-title":"Therapeutic Drug Monitor"},{"key":"ref25","first-page":"83","volume":"15","author":"Zhou","year":"2002","journal-title":"Biomed Environ Sci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s00406-019-01043-8","volume":"270","author":"Barton","year":"2020","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.jad.2019.06.067","volume":"256","author":"Dreim\u00fcller","year":"2019","journal-title":"J Affect Disord"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2165\/11319480-000000000-00000","volume":"24","author":"Watanabe","year":"2010","journal-title":"CNS Drugs"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.4088\/JCP.09r05346blu","volume":"71","author":"Serretti","year":"2010","journal-title":"J Clin Psychiatry"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3390\/jcm5040048","volume":"5","author":"Arterburn","year":"2016","journal-title":"J Clin Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1208\/s12248-024-00929-3","volume":"26","author":"Zhang","year":"2024","journal-title":"AAPS J"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"115281","DOI":"10.1016\/j.biopha.2023.115281","volume":"166","author":"Gouju","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.xphs.2020.10.027","volume":"110","author":"Krogstad","year":"2021","journal-title":"J Pharm Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/clpt.2012.261","volume":"93","author":"Ulvestad","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2174\/1389200013338676","volume":"2","author":"Cheng","year":"2001","journal-title":"Curr Drug Metab"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e70013","DOI":"10.1111\/bcpt.70013","volume":"136","author":"Hole","year":"2025","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.2174\/1386207323666200402081512","volume":"23","author":"Ozdemir","year":"2020","journal-title":"Comb Chem High Throughput Screen"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/jcpt.12042","volume":"38","author":"Ju\u0159ica","year":"2013","journal-title":"J Clin Pharm Ther"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.euroneuro.2009.01.015","volume":"19","author":"Blier","year":"2009","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"55","DOI":"10.17712\/nsj.2020.1.20190058","volume":"25","author":"AlBreiki","year":"2020","journal-title":"Neurosciences (Riyadh)"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/j.1742-1241.2010.02624.x","volume":"65","author":"Kim","year":"2011","journal-title":"Int J Clin Pract"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3390\/ph18050711","volume":"18","author":"Dieckmann","year":"2025","journal-title":"Pharmaceuticals"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1097\/JCP.0000000000000329","volume":"35","author":"Alberti","year":"2015","journal-title":"J Clin Psychopharmacol"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115895","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:40:26Z","timestamp":1780418426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/optimizing-mirtazapine-initial-dosing-a-population-analysis-of-the-eff-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":43,"URL":"https:\/\/doi.org\/10.2147\/dddt.s601238","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}