{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:42:32Z","timestamp":1790862152883,"version":"4.1.0"},"reference-count":75,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s602971","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:45:15Z","timestamp":1779421515000},"page":"1-11","source":"Crossref","is-referenced-by-count":1,"title":["Methylene Blue for Prevention of Perioperative Neurocognitive Disorders: Mechanisms and Recent Clinical Evidence"],"prefix":"10.2147","volume":"Volume 20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0139-8105","authenticated-orcid":true,"given":"Yu","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0445-4511","authenticated-orcid":true,"given":"Jinbao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1097\/ALN.0000000000002334","volume":"129","author":"Evered","year":"2018","journal-title":"Anesthesiology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/JS9.0000000000000001","volume":"109","author":"Zeng","year":"2023","journal-title":"Int J Surg"},{"key":"ref3","first-page":"278","volume":"108","author":"Jaqua","year":"2023","journal-title":"Am Fam Physician"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/ALN.0000000000005276","volume":"142","author":"Li","year":"2025","journal-title":"Anesthesiology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e14343","DOI":"10.1111\/cns.14343","volume":"30","author":"Chen","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1001\/jamaneurol.2020.2273","volume":"77","author":"Goldberg","year":"2020","journal-title":"JAMA Neurol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S2213-2600(24)00077-8","volume":"12","author":"Mart","year":"2024","journal-title":"Lancet Respir Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/med.20177","volume":"31","author":"Oz","year":"2011","journal-title":"Med Res Rev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"16504","DOI":"10.1074\/jbc.M110.208447","volume":"286","author":"Wen","year":"2011","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/j.jagp.2013.09.005","volume":"21","author":"Maldonado","year":"2013","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"110108","DOI":"10.1016\/j.jclinane.2020.110108","volume":"68","author":"Deng","year":"2021","journal-title":"J Clin Anesth"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1111\/cns.13784","volume":"28","author":"Sun","year":"2022","journal-title":"CNS Neurosci Ther"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e91229","DOI":"10.1172\/jci.insight.91229","volume":"2","author":"Feng","year":"2017","journal-title":"JCI Insight"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10753-022-01721-1","volume":"46","author":"Thakur","year":"2023","journal-title":"Inflammation"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12974-023-02853-3","volume":"20","author":"Chen","year":"2023","journal-title":"J Neuroinflammation"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12974-024-03103-w","volume":"21","author":"Kong","year":"2024","journal-title":"J Neuroinflammation"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41423-025-01275-w","volume":"22","author":"Xu","year":"2025","journal-title":"Cell Mol Immunol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s13019-020-01179-y","volume":"15","author":"Naase","year":"2020","journal-title":"J Cardiothorac Surg"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e71173","DOI":"10.1096\/fj.202502255RR","volume":"39","author":"Wu","year":"2025","journal-title":"FASEB J"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s43465-024-01195-3","volume":"58","author":"Laishram","year":"2024","journal-title":"Indian J Orthop"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"175966","DOI":"10.1016\/j.ejphar.2023.175966","volume":"956","author":"Fan","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.freeradbiomed.2014.07.033","volume":"76","author":"Bordt","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.nbd.2011.12.022","volume":"45","author":"Boscolo","year":"2012","journal-title":"Neurobiol Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"5787","DOI":"10.1007\/s12035-024-03931-0","volume":"61","author":"Wu","year":"2024","journal-title":"Mol Neurobiol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.brainresbull.2014.10.011","volume":"110","author":"Li","year":"2015","journal-title":"Brain Res Bull"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12264-024-01265-4","volume":"41","author":"Wang","year":"2025","journal-title":"Neurosci Bull"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1038\/jcbfm.2013.135","volume":"33","author":"Erickson","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"100052","DOI":"10.1016\/j.pharmr.2025.100052","volume":"77","author":"Divecha","year":"2025","journal-title":"Pharmacol Rev"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1002\/ana.22664","volume":"70","author":"Terrando","year":"2011","journal-title":"Ann Neurol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2325e7","DOI":"10.1016\/j.neurobiolaging.2010.12.012","volume":"32","author":"Schirmer","year":"2011","journal-title":"Neurobiol Aging"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"S439","DOI":"10.3233\/JAD-2010-100414","volume":"20","author":"Atamna","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1016\/S0090-9556(25)08471-5","volume":"24","author":"Aeschlimann","year":"1996","journal-title":"Drug Metab Dispos"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1134\/S0006297922090073","volume":"87","author":"Gureev","year":"2022","journal-title":"Biochemistry"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"W513","DOI":"10.1093\/nar\/gkae303","volume":"52","author":"Banerjee","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci Rep"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e0152677","DOI":"10.1371\/journal.pone.0152677","volume":"11","author":"Senarathna","year":"2016","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1080\/00207454.2018.1483920","volume":"129","author":"Guo","year":"2019","journal-title":"Int J Neurosci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"4948","DOI":"10.18632\/aging.205147","volume":"16","author":"Poudel","year":"2024","journal-title":"Aging"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"5137","DOI":"10.1007\/s12035-017-0712-2","volume":"55","author":"Tucker","year":"2018","journal-title":"Mol Neurobiol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"111497","DOI":"10.1016\/j.brainresbull.2025.111497","volume":"230","author":"He","year":"2025","journal-title":"Brain Res Bull"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1007\/s11064-020-02976-6","volume":"45","author":"Zheng","year":"2020","journal-title":"Neurochem Res"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/01.anes.0000299435.59242.0e","volume":"108","author":"Wei","year":"2008","journal-title":"Anesthesiology"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.neures.2016.07.006","volume":"113","author":"Gureev","year":"2016","journal-title":"Neurosci Res"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.1093\/hmg\/ddu080","volume":"23","author":"Stack","year":"2014","journal-title":"Hum Mol Genet"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e48051","DOI":"10.1371\/journal.pone.0048051","volume":"7","author":"Fujita","year":"2012","journal-title":"PLoS One"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1080\/09273948.2018.1450516","volume":"27","author":"Hao","year":"2019","journal-title":"Ocul Immunol Inflamm"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"12409","DOI":"10.1038\/s41598-017-12635-6","volume":"7","author":"Ahn","year":"2017","journal-title":"Sci Rep"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.tins.2017.01.002","volume":"40","author":"Kerr","year":"2017","journal-title":"Trends Neurosci"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"42201","DOI":"10.1038\/s41598-025-26108-8","volume":"15","author":"Deng","year":"2025","journal-title":"Sci Rep"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"11213","DOI":"10.1073\/pnas.93.20.11213","volume":"93","author":"Wischik","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","volume":"388","author":"Scheltens","year":"2016","journal-title":"Lancet"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e48279","DOI":"10.1371\/journal.pone.0048279","volume":"7","author":"Poteet","year":"2012","journal-title":"PLoS One"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cbi.2012.10.021","volume":"203","author":"Silman","year":"2013","journal-title":"Chem Biol Interact"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/sj.bjp.0707430","volume":"152","author":"Ramsay","year":"2007","journal-title":"Br J Pharmacol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.7150\/ijbs.102234","volume":"21","author":"Li","year":"2025","journal-title":"Int J Biol Sci"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1186\/s12967-023-04345-7","volume":"21","author":"Liu","year":"2023","journal-title":"J Transl Med"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1097\/CJI.0b013e31821dcb50","volume":"34","author":"Samlowski","year":"2011","journal-title":"J Immunother"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"5052","DOI":"10.1007\/s12035-021-02417-7","volume":"58","author":"Wang","year":"2021","journal-title":"Mol Neurobiol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e130","DOI":"10.1097\/AS9.0000000000000130","volume":"3","author":"Singh","year":"2022","journal-title":"Ann Surg Open"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/S0140-6736(17)31504-0","volume":"390","author":"Eisenach","year":"2017","journal-title":"Lancet"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"137095","DOI":"10.1016\/j.neulet.2023.137095","volume":"798","author":"Horacek","year":"2023","journal-title":"Neurosci Lett"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1016\/S2215-0366(19)30522-X","volume":"7","author":"Morris","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1136\/bmjebm-2019-111293","volume":"26","author":"Heneghan","year":"2021","journal-title":"BMJ Evid Based Med"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.2174\/1570159X20666220507024219","volume":"20","author":"Maneeton","year":"2022","journal-title":"Curr Neuropharmacol"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"9384","DOI":"10.1097\/JS9.0000000000002981","volume":"111","author":"Zhang","year":"2025","journal-title":"Int J Surg"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"112060","DOI":"10.1016\/j.jclinane.2025.112060","volume":"108","author":"Deng","year":"2026","journal-title":"J Clin Anesth"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"146854","DOI":"10.1016\/j.brainres.2020.146854","volume":"1740","author":"Genrikhs","year":"2020","journal-title":"Brain Res"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1177\/0269881109359098","volume":"25","author":"Gillman","year":"2011","journal-title":"J Psychopharmacol"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1002\/ajh.27324","volume":"99","author":"Tatarinova","year":"2024","journal-title":"Am J Hematol"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.3390\/diagnostics14192113","volume":"14","author":"De Cassai","year":"2024","journal-title":"Diagnostics"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.bja.2022.01.005","volume":"129","author":"Taylor","year":"2022","journal-title":"Br J Anaesth"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/01.anes.0000296072.02527.18","volume":"108","author":"Price","year":"2008","journal-title":"Anesthesiology"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.drudis.2021.01.019","volume":"26","author":"Granger","year":"2021","journal-title":"Drug Discov Today"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115495","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:45:24Z","timestamp":1779421524000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/methylene-blue-for-prevention-of-perioperative-neurocognitive-disorder-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":75,"URL":"https:\/\/doi.org\/10.2147\/dddt.s602971","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}