{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:05:14Z","timestamp":1779278714313,"version":"3.51.4"},"reference-count":193,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s605798","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:05:14Z","timestamp":1779275114000},"page":"1-23","source":"Crossref","is-referenced-by-count":0,"title":["Aspirin in Audiology: A Dual-Edged Sword in Hearing Loss and Its Nanotechnology-Driven Future"],"prefix":"10.2147","volume":"Volume 20","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogang","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingjun","family":"Zha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2025.05.011","volume":"410","author":"Zeng","year":"2025","journal-title":"Toxicol Lett"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e217","DOI":"10.1016\/s2214-109x(23)00514-4","volume":"12","author":"Prasad","year":"2024","journal-title":"Lancet Global Health"},{"key":"ref3","first-page":"S0030666518300069","author":"Brown","year":"2018","journal-title":"Otolaryngol Clin North Am"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e25129","DOI":"10.1016\/j.heliyon.2024.e25129","volume":"10","author":"Curtasu","year":"2024","journal-title":"Heliyon"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14010029","volume":"14","author":"Kontoghiorghes","year":"2024","journal-title":"Antioxidants"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1001\/jamaoncol.2024.2503","volume":"10","author":"Sikavi","year":"2024","journal-title":"JAMA Oncol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1093\/jnci\/djad231","volume":"116","author":"Skriver","year":"2023","journal-title":"JNCI"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1002\/ijc.35331","volume":"156","author":"Lam","year":"2025","journal-title":"Int, J, Cancer"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"4276","DOI":"10.1002\/cncr.35510","volume":"130","author":"Pastorino","year":"2024","journal-title":"Cancer"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1136\/gutjnl-2024-333329","volume":"74","author":"Tan","year":"2025","journal-title":"Gut"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1038\/s41416-024-02609-7","volume":"130","author":"Zheng","year":"2024","journal-title":"Br J Cancer"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1521043","DOI":"10.3389\/fneur.2025.1521043","volume":"16","author":"Huang","year":"2025","journal-title":"Front Neurol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s12640-013-9384-5","volume":"24","author":"Deng","year":"2013","journal-title":"Neurotoxicity Res"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.neuro.2022.10.013","volume":"93","author":"Fogliano","year":"2022","journal-title":"Neurotoxicology"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"112154","DOI":"10.1016\/j.biopha.2021.112154","volume":"143","author":"Abdeen","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"587,authorreply587","DOI":"10.15537\/1658-3175.5042","volume":"31","author":"Naeem","year":"2010","journal-title":"Saudi Med J"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.heares.2006.05.008","volume":"226","author":"Chen","year":"2007","journal-title":"Hearing Res"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12050587","volume":"12","author":"Kitano","year":"2022","journal-title":"Brain Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1056\/NEJMc053428","volume":"354","author":"Sha","year":"2006","journal-title":"New Eng J Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e2424373","DOI":"10.1001\/jamanetworkopen.2024.24373","volume":"7","author":"Clark","year":"2024","journal-title":"JAMA Netw Open"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ejca.2017.09.033","volume":"87","author":"Crabb","year":"2017","journal-title":"Eur J Cancer"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3109\/00498258609043527","volume":"16","author":"Hutt","year":"1986","journal-title":"Xenobiotica"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"847","DOI":"10.3109\/00498259009046898","volume":"20","author":"Patel","year":"1990","journal-title":"Xenobiotica"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105150","volume":"25","author":"Kontoghiorghes","year":"2024","journal-title":"Int J Mole Sci"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04282-w","author":"Hu","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239018","volume":"21","author":"Sankaranarayanan","year":"2020","journal-title":"Int J Mole Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1007\/s11886-022-01740-2","volume":"24","author":"Dimitriadis","year":"2022","journal-title":"Curr Cardiol Rep"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1001\/archotol.1990.01870060039005","volume":"116","author":"Boettcher","year":"1990","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"104431","DOI":"10.1016\/j.amjoto.2024.104431","volume":"45","author":"Conway","year":"2024","journal-title":"Ame J Otolaryngol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/bph.15966","volume":"180","author":"Patrono","year":"2023","journal-title":"British J Pharmacol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1021\/acs.jmedchem.5c01581","volume":"69","author":"Solidoro","year":"2026","journal-title":"J Med Chem"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e20652","DOI":"10.1371\/journal.pone.0020652","volume":"6","author":"Dai","year":"2011","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1159\/000081885","volume":"66","author":"Ziegler","year":"2004","journal-title":"ORL"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.26402\/jpp.2023.5.08","volume":"74","author":"Kwiecie\u0144","year":"2023","journal-title":"J Physiol Pharmacol"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.2174\/0113895575385764250711091807","author":"Khormi","year":"2025","journal-title":"Mini Rev Med Chem"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3892\/mi.2024.184","volume":"4","author":"Samara","year":"2024","journal-title":"Med Int"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1080\/00016480903168066","volume":"130","author":"Heinrich","year":"2010","journal-title":"Acta oto-laryngologica"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1620\/tjem.216.53","volume":"216","author":"Hoshino","year":"2008","journal-title":"Tohoku J Experim Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/cdt3.120","volume":"10","author":"Liu","year":"2024","journal-title":"Chronic Dis Transl Med"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"604","DOI":"10.34172\/apb.2024.055","volume":"14","author":"Akl","year":"2024","journal-title":"Adv Pharmaceu Bulletin"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015130","volume":"24","author":"Yang","year":"2023","journal-title":"Int J Mole Sci"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1557790","DOI":"10.3389\/fimmu.2025.1557790","volume":"16","author":"Sakurai","year":"2025","journal-title":"Front immunol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"22573","DOI":"10.1038\/srep22573","volume":"6","author":"Sun","year":"2016","journal-title":"Sci Rep"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415790","volume":"23","author":"Anfuso","year":"2022","journal-title":"Int J Mole Sci"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.143285","volume":"6","author":"Zhang","year":"2021","journal-title":"JCI Insight"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"e0279010","DOI":"10.1371\/journal.pone.0279010","volume":"17","author":"Wu","year":"2022","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/s41419-023-06144-w","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"3373828","DOI":"10.1155\/2022\/3373828","volume":"2022","author":"Ma","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"e2402671","DOI":"10.1002\/advs.202402671","volume":"11","author":"Wang","year":"2024","journal-title":"Adv Sci"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/j.ymthe.2024.02.029","volume":"32","author":"Liu","year":"2024","journal-title":"Mole Therapy"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"117816","DOI":"10.1016\/j.bcp.2026.117816","volume":"248","author":"Li","year":"2026","journal-title":"Biochem Pharmacol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1309115","DOI":"10.3389\/fnagi.2024.1309115","volume":"16","author":"Zeng","year":"2024","journal-title":"Front Aging Neurosci"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/s41586-025-08626-7","volume":"640","author":"Yang","year":"2025","journal-title":"Nature"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1514264","DOI":"10.3389\/fendo.2025.1514264","volume":"16","author":"Zou","year":"2025","journal-title":"Front Endocrinol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00068-025-02783-0","volume":"51","author":"Zuhour","year":"2025","journal-title":"Euro J Traumaemerge Surg"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1172\/jci109203","volume":"62","author":"Kelton","year":"1978","journal-title":"J clin Invest"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1212\/wnl.57.suppl_2.s5","volume":"57","author":"Catella-Lawson","year":"2001","journal-title":"Neurology"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"23","DOI":"10.7874\/kja.2013.17.1.23","volume":"17","author":"Kim","year":"2013","journal-title":"Korean J Audiol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1093\/cvr\/cvae254","volume":"121","author":"Talabieke","year":"2025","journal-title":"Cardiovascular Res"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.biopha.2017.08.085","volume":"95","author":"Ma","year":"2017","journal-title":"Biomed pharmacothe"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.2147\/ijn.s505636","volume":"20","author":"Laila","year":"2025","journal-title":"Int J Nanomed"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.2147\/JIR.S364190","volume":"15","author":"Srour","year":"2022","journal-title":"J Inflamm Res"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"6166","DOI":"10.1007\/s12035-024-04675-7","volume":"62","author":"Liu","year":"2025","journal-title":"Mole Neurobiol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s11033-024-10098-3","volume":"51","author":"Xu","year":"2024","journal-title":"Mole Biol Rep"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"e0298529","DOI":"10.1371\/journal.pone.0298529","volume":"19","author":"Zhang","year":"2024","journal-title":"PLoS One"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"22242","DOI":"10.1038\/s41598-025-08075-2","volume":"15","author":"Gong","year":"2025","journal-title":"Sci Rep"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.neuroscience.2023.09.004","volume":"531","author":"Goodarzi","year":"2023","journal-title":"Neuroscience"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1455136","DOI":"10.3389\/fnmol.2024.1455136","volume":"17","author":"Bieniussa","year":"2024","journal-title":"Front Mol Neurosci"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"115440","DOI":"10.1016\/j.bcp.2023.115440","volume":"209","author":"Jiang","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"109758","DOI":"10.1016\/j.celrep.2021.109758","volume":"36","author":"Milon","year":"2021","journal-title":"Cell Rep"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"4341","DOI":"10.1080\/15548627.2021.1916194","volume":"17","author":"He","year":"2021","journal-title":"Autophagy"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1158\/0008-5472.can-16-2400","volume":"77","author":"Henry","year":"2017","journal-title":"Cancer Res"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1158\/1940-6207.capr-13-0337","volume":"7","author":"Yue","year":"2014","journal-title":"Cancer Prev Res"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"112085","DOI":"10.1016\/j.exger.2023.112085","volume":"172","author":"Peng","year":"2023","journal-title":"Exp Gerontol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"7497","DOI":"10.1523\/jneurosci.0782-16.2016","volume":"36","author":"Hill","year":"2016","journal-title":"J Neurosci"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"101406","DOI":"10.1016\/j.redox.2019.101406","volume":"29","author":"Wu","year":"2020","journal-title":"Redox Biol"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1484998","DOI":"10.3389\/fncel.2024.1484998","volume":"18","author":"Sinha","year":"2024","journal-title":"Front Cell Neurosci"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.conb.2008.08.016","volume":"18","author":"Dallos","year":"2008","journal-title":"Curr Opin Neurobiol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/bcpt.12640","volume":"120","author":"Alvan","year":"2017","journal-title":"Basic Clin. Physiol. Pharmacol"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1007\/s00018-008-8195-y","volume":"65","author":"Yu","year":"2008","journal-title":"Cellular Mole Life Sci"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/s41586-021-04152-4","volume":"600","author":"Bavi","year":"2021","journal-title":"Nature"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.89635","volume":"12","author":"Lin","year":"2023","journal-title":"eLife"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"6208","DOI":"10.1038\/s41467-022-34017-x","volume":"13","author":"Futamata","year":"2022","journal-title":"Nat Commun"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10571-025-01633-2","volume":"46","author":"Zhang","year":"2025","journal-title":"Cell Mol Neurobiol"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.heares.2010.02.010","volume":"265","author":"Chen","year":"2010","journal-title":"Hearing Res"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3109\/10799893.2011.641975","volume":"32","author":"Senol","year":"2012","journal-title":"J Receptor Signal Transduct Res"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"3949161","DOI":"10.1155\/2020\/3949161","volume":"2020","author":"Zhang","year":"2020","journal-title":"Neural Plast"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1023\/a:1006934612368","volume":"199","author":"Shi","year":"1999","journal-title":"Mol Cell Biochem"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.neuroscience.2005.04.015","volume":"134","author":"Yamashita","year":"2005","journal-title":"Neuroscience"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/s0014-5793(97)01307-0","volume":"417","author":"Podhaisky","year":"1997","journal-title":"FEBS Lett"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/0891-5849(90)90004-3","volume":"9","author":"Woollard","year":"1990","journal-title":"Free Radic Biol Med"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3109\/00498258809041682","volume":"18","author":"Aruoma","year":"1988","journal-title":"Xenobiotica"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"167024","DOI":"10.1016\/j.bbadis.2024.167024","volume":"1870","author":"Lu","year":"2024","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.heares.2005.10.016","volume":"212","author":"Severinsen","year":"2006","journal-title":"Hearing Res"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"e2326320","DOI":"10.1001\/jamanetworkopen.2023.26320","volume":"6","author":"Reed","year":"2023","journal-title":"JAMA Netw Open"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"837","DOI":"10.3389\/fnhum.2013.00837","volume":"7","author":"Kiely","year":"2013","journal-title":"Front Human Neurosci"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.cct.2015.11.014","volume":"46","author":"Lowthian","year":"2016","journal-title":"Contemporary Clin Trials"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1016\/j.celrep.2018.02.024","volume":"22","author":"Pietrocola","year":"2018","journal-title":"Cell Rep"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1080\/15548627.2018.1454810","volume":"14","author":"Pietrocola","year":"2018","journal-title":"Autophagy"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000541895","volume":"71","author":"Britt","year":"2024","journal-title":"Gerontology"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"e15669","DOI":"10.14814\/phy2.15669","volume":"11","author":"Fountain","year":"2023","journal-title":"Physiolog Rep"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.14336\/ad.2020.1008","volume":"12","author":"Zhu","year":"2021","journal-title":"Aging and Disease"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"783346","DOI":"10.3389\/fncel.2022.783346","volume":"16","author":"Yang","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.3390\/audiolres15020022","volume":"15","author":"Orasan","year":"2025","journal-title":"Audiol Res"},{"key":"ref105","first-page":"873","volume":"36","author":"Fatima Zaidi","year":"2023","journal-title":"Pak J Pharm Sci"},{"key":"ref106","first-page":"869","volume":"34","author":"Fatimah","year":"2021","journal-title":"Pak J Pharm Sci"},{"key":"ref107","first-page":"165","volume":"34","author":"Zaidi","year":"2021","journal-title":"Pak J Pharm Sci"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"390613","DOI":"10.1100\/2012\/390613","volume":"2012","author":"Randjelovic","year":"2012","journal-title":"Sci. World J"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1002\/lary.31902","volume":"135","author":"Gaffney","year":"2025","journal-title":"Laryngoscope"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1007\/s00432-022-04144-5","volume":"149","author":"Tzelnick","year":"2023","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/labinvest.3780453","volume":"82","author":"Li","year":"2002","journal-title":"Lab investigat"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1097\/mao.0000000000004446","volume":"46","author":"Briggs","year":"2025","journal-title":"Otol Neurotol"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"867034","DOI":"10.3389\/fnins.2022.867034","volume":"16","author":"Waissbluth","year":"2022","journal-title":"Front Neurosci"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"0324","DOI":"10.34133\/bmr.0324","volume":"30","author":"Liu","year":"2026","journal-title":"Biomater Res"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s12265-023-10372-y","volume":"16","author":"Koyama","year":"2023","journal-title":"J. Cardiovasc.\u00a0Transl.\u00a0Res"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1177\/0194599814553930","volume":"152","author":"Kyle","year":"2015","journal-title":"Otolaryngol -Head Neck Surg"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"109319","DOI":"10.1016\/j.heares.2025.109319","volume":"464","author":"Zhao","year":"2025","journal-title":"Hearing Res"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1001\/archotol.1989.01860330060017","volume":"115","author":"Carson","year":"1989","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1001\/archotol.1986.03780100031003","volume":"112","author":"Lambert","year":"1986","journal-title":"Noise and Aspirin Toxicity Archives of Otolaryngology--Head & Neck Surgery"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1745-6673-7-1","volume":"7","author":"de Jong","year":"2012","journal-title":"J Occupat Med Toxicol"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/s0196-0709(84)80033-2","volume":"5","author":"McFadden","year":"1984","journal-title":"Am.\u00a0J.\u00a0Otolaryngol"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0378-5955(83)90033-3","volume":"9","author":"McFadden","year":"1983","journal-title":"Hearing Res"},{"key":"ref123","first-page":"41","volume":"26","author":"Lindgren","year":"1986","journal-title":"Scandinavian Audiol Supplement"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fnsys.2012.00028","volume":"6","author":"Stolzberg","year":"2012","journal-title":"Front Syst Neurosci"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1080\/14992027.2018.1544424","volume":"58","author":"Wood","year":"2019","journal-title":"Int j audiol"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"733004","DOI":"10.3389\/fncel.2021.733004","volume":"15","author":"Wang","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1044\/2020_aja-20-00023","volume":"30","author":"Salvi","year":"2021","journal-title":"Ame j audiol"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/03005369209077876","volume":"26","author":"Penner","year":"1992","journal-title":"Br J Audiol"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"109217","DOI":"10.1016\/j.heares.2025.109217","volume":"459","author":"Liu","year":"2025","journal-title":"Hearing Res"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s13181-021-00865-0","volume":"18","author":"Isoardi","year":"2022","journal-title":"J Med Toxicol"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1177\/09622802221133556","volume":"32","author":"Langworthy","year":"2023","journal-title":"Stat Methods Med Res"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"242","DOI":"10.18502\/jfrh.v15i4.7890","volume":"15","author":"Karimi Yazdi","year":"2021","journal-title":"J Family Reproduct Health"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"445","DOI":"10.12688\/f1000research.11131.2","volume":"6","author":"Pokharel","year":"2017","journal-title":"F1000Research"},{"key":"ref134","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/ijn.ijn_141_22","volume":"34","author":"Kulkarni","year":"2024","journal-title":"Indian J Nephrol"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"378","DOI":"10.5152\/iao.2022.21485","volume":"18","author":"Noh","year":"2022","journal-title":"J Int Adv Otol"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.heares.2016.10.021","volume":"347","author":"Jiang","year":"2017","journal-title":"Hearing Res"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3389\/fnbeh.2016.00158","volume":"10","author":"Yu","year":"2016","journal-title":"Front Behav Neurosci"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.heares.2012.11.016","volume":"295","author":"Chen","year":"2013","journal-title":"Hearing Res"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"84","DOI":"10.2174\/1573397115666191016101741","volume":"16","author":"Riera","year":"2020","journal-title":"Curr rheumatol rev"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/rheumatology\/17.4.233","volume":"17","author":"Jardini","year":"1978","journal-title":"Rheumatol rehabil"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1121\/1.1985043","volume":"118","author":"Abdala","year":"2005","journal-title":"J Acoust Soc Am"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3109\/00206097909072627","volume":"18","author":"Bonding","year":"1979","journal-title":"Audiology"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1365-2125.1989.tb03562.x","volume":"28","author":"Day","year":"1989","journal-title":"Br J Clin Pharmacol"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1002\/cpt1979255part1618","volume":"25","author":"Davis","year":"1979","journal-title":"Clin Pharmacol Ther"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1136\/ard.47.2.134","volume":"47","author":"Halla","year":"1988","journal-title":"Ann Rheumatic Dis"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1017\/s0022215100067852","volume":"81","author":"Bernstein","year":"1967","journal-title":"J Laryngology Otol"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3109\/03009747209103000","volume":"1","author":"Heyworth","year":"1972","journal-title":"Scand J Rheumatol"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1001\/archotol.1965.00760010485006","volume":"82","author":"Myers","year":"1965","journal-title":"Arch Otolaryngol"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"115283","DOI":"10.1016\/j.addr.2024.115283","volume":"208","author":"Di Francesco","year":"2024","journal-title":"Adv Drug Delivery Rev"},{"key":"ref150","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202008701","volume":"31","author":"Zhang","year":"2021","journal-title":"Adv Funct Mater"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1097\/AUD.0b013e3181c351f2","volume":"31","author":"McCall","year":"2010","journal-title":"Ear Hear"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ejps.2018.05.020","volume":"126","author":"Hao","year":"2019","journal-title":"Eur J Pharm Sci"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"108228","DOI":"10.1016\/j.heares.2021.108228","volume":"404","author":"Manrique-Huarte","year":"2021","journal-title":"Hear Res"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00106-016-0285-9","volume":"65","author":"Plontke","year":"2017","journal-title":"HNO"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1007\/s13346-018-0539-z","volume":"8","author":"Prenzler","year":"2018","journal-title":"Drug Deliv Transl Res"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s13346-021-00914-9","volume":"12","author":"Lehner","year":"2022","journal-title":"Drug Deliv Transl Res"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1159\/000089407","volume":"67","author":"Ito","year":"2005","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1073\/pnas.032677999","volume":"99","author":"Shinohara","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/s0378-5955(98)00095-1","volume":"124","author":"Ylikoski","year":"1998","journal-title":"Hear Res"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0378-5955(93)90155-t","volume":"70","author":"Brown","year":"1993","journal-title":"Hear Res"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jconrel.2011.02.021","volume":"152","author":"Pararas","year":"2011","journal-title":"J Control Release"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jconrel.2005.09.003","volume":"110","author":"Chen","year":"2005","journal-title":"J Control Release"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s10544-014-9923-8","volume":"17","author":"Tandon","year":"2015","journal-title":"Biomed Microdevices"},{"key":"ref164","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11030358","volume":"11","author":"Guigou","year":"2021","journal-title":"Brain Sci"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.biomaterials.2018.04.038","volume":"171","author":"Yang","year":"2018","journal-title":"Biomaterials"},{"key":"ref166","doi-asserted-by":"publisher","first-page":"3098230","DOI":"10.1155\/2017\/3098230","volume":"2017","author":"Kim","year":"2017","journal-title":"Biomed Res Int"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fncel.2019.00261","volume":"13","author":"Patel","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.heares.2018.03.006","volume":"368","author":"Mader","year":"2018","journal-title":"Hear Res"},{"key":"ref169","doi-asserted-by":"publisher","first-page":"809443","DOI":"10.3389\/fbioe.2021.809443","volume":"9","author":"Lin","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"e2408798","DOI":"10.1002\/advs.202408798","volume":"12","author":"Li","year":"2025","journal-title":"Adv Sci"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"114393","DOI":"10.1016\/j.ejpb.2024.114393","volume":"202","author":"Hajmohammadi","year":"2024","journal-title":"Euro J Pharmaceu Biopharmaceu"},{"key":"ref172","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-025-03912-5","author":"Ferdushi","year":"2025","journal-title":"Pharm Res"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"131742","DOI":"10.1016\/j.ijbiomac.2024.131742","volume":"268","author":"Huang","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.colsurfb.2011.12.033","volume":"93","author":"Das","year":"2012","journal-title":"Colloids Surf B"},{"key":"ref175","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.actbio.2022.06.026","volume":"148","author":"Sun","year":"2022","journal-title":"Acta Biomater"},{"key":"ref176","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.3892\/ijo.2012.1636","volume":"41","author":"Sutaria","year":"2012","journal-title":"Int J Oncol"},{"key":"ref177","doi-asserted-by":"publisher","first-page":"5399","DOI":"10.1039\/d3na00368j","volume":"5","author":"Sedky","year":"2023","journal-title":"Nanoscale Adv"},{"key":"ref178","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.jconrel.2024.05.002","volume":"370","author":"Ma","year":"2024","journal-title":"J Controlled Release"},{"key":"ref179","doi-asserted-by":"publisher","first-page":"33232","DOI":"10.1021\/acsnano.4c12676","volume":"18","author":"Chen","year":"2024","journal-title":"ACS nano"},{"key":"ref180","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13070842","volume":"13","author":"Maniaci","year":"2024","journal-title":"Antioxidants"},{"key":"ref181","doi-asserted-by":"publisher","first-page":"4159","DOI":"10.1080\/15548627.2021.1905466","volume":"17","author":"Liu","year":"2021","journal-title":"Autophagy"},{"key":"ref182","doi-asserted-by":"publisher","first-page":"7102","DOI":"10.1021\/acsami.0c21151","volume":"13","author":"Zhao","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref183","doi-asserted-by":"publisher","first-page":"e2306389","DOI":"10.1002\/smll.202306389","volume":"20","author":"Zhang","year":"2024","journal-title":"Small"},{"key":"ref184","doi-asserted-by":"publisher","first-page":"e2303016","DOI":"10.1002\/adhm.202303016","volume":"13","author":"Liang","year":"2024","journal-title":"Adv Healthcare Mater"},{"key":"ref185","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41419-023-05912-y","volume":"14","author":"Richard","year":"2023","journal-title":"Cell Death Dis"},{"key":"ref186","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.2217\/nnm-2020-0198","volume":"15","author":"An","year":"2020","journal-title":"Nanomedicine"},{"key":"ref187","doi-asserted-by":"publisher","first-page":"120926","DOI":"10.1016\/j.ijpharm.2021.120926","volume":"606","author":"Abuhamdan","year":"2021","journal-title":"Int J Pharm"},{"key":"ref188","doi-asserted-by":"publisher","first-page":"e2307081","DOI":"10.1002\/adma.202307081","volume":"36","author":"Liu","year":"2024","journal-title":"Adv Mater"},{"key":"ref189","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1124\/pharmrev.124.001195","volume":"76","author":"Cederroth","year":"2024","journal-title":"Pharmacol Rev"},{"key":"ref190","doi-asserted-by":"publisher","first-page":"115575","DOI":"10.1016\/j.bcp.2023.115575","volume":"212","author":"Li","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"ref191","doi-asserted-by":"publisher","first-page":"299","DOI":"10.2217\/pme-2022-0074","volume":"20","author":"Rutten-van M\u00f6lken","year":"2023","journal-title":"Personalized Medicine"},{"key":"ref192","doi-asserted-by":"publisher","first-page":"120222","DOI":"10.1016\/j.cca.2025.120222","volume":"571","author":"Koohkansaadi","year":"2025","journal-title":"Int J Clin Chem"},{"key":"ref193","doi-asserted-by":"publisher","first-page":"114961","DOI":"10.1016\/j.jpba.2022.114961","volume":"219","author":"Cheng","year":"2022","journal-title":"J Pharm Biomed Anal"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115431","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:05:17Z","timestamp":1779275117000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/aspirin-in-audiology-a-dual-edged-sword-in-hearing-loss-and-its-nanote-peer-reviewed-fulltext-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":193,"URL":"https:\/\/doi.org\/10.2147\/dddt.s605798","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}