{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:34:43Z","timestamp":1789439683861,"version":"build-2803163510"},"reference-count":48,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DMSO"],"DOI":"10.2147\/dmso.s525913","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:18:17Z","timestamp":1761056297000},"page":"3907-3930","source":"Crossref","is-referenced-by-count":2,"title":["Mechanisms of Dangguiliuhuang Tang in Streptozotocin-Induced Type 2 Diabetes Mellitus Mice Based on Network Pharmacology, Gut Microbiota, and Experimental Validation"],"prefix":"10.2147","volume":"Volume 18","author":[{"given":"Xianglong","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhulin","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuosheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature18646","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.2174\/1570161117666190405165911","volume":"18","author":"Lovic","year":"2020","journal-title":"Curr Vasc Pharmacol"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"American Diabetes Association. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2018. Diabetes Care. 2018;41(Suppl 1):S13\u2013s27. doi:10.2337\/dc18-S002","DOI":"10.2337\/dc18-S002"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","volume":"128","author":"Ogurtsova","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1161\/ATVBAHA.117.310221","volume":"38","author":"Schmidt","year":"2018","journal-title":"Arteriosclerosis Thrombosis Vasc Biol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrendo.2017.151","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"154054","DOI":"10.1016\/j.metabol.2019.154054","volume":"104","author":"Guardado-Mendoza","year":"2020","journal-title":"Metabolism"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1186\/s12933-021-01434-z","volume":"20","author":"Song","year":"2021","journal-title":"Cardiovasc Diabetol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13020-023-00783-z","volume":"18","author":"Meng","year":"2023","journal-title":"ChinMed"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"13982","DOI":"10.1038\/srep13982","volume":"5","author":"Liu","year":"2015","journal-title":"Sci Rep"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"5627","DOI":"10.19540\/j.cnki.cjcmm.20210323.302","volume":"46","author":"Meng","year":"2021","journal-title":"Chin J Trad Chin Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"119170","DOI":"10.1016\/j.jep.2024.119170","volume":"340","author":"Xu","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nrg.2018.4","volume":"19","author":"Karczewski","year":"2018","journal-title":"Nat Rev Genet"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.biopha.2017.03.056","volume":"90","author":"Karbasforooshan","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e2203894119","DOI":"10.1073\/pnas.2203894119","volume":"119","author":"Chen","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"6054","DOI":"10.1073\/pnas.2203894119","volume":"21","author":"Hankittichai","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.atherosclerosis.2018.05.042","volume":"275","author":"Sung","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.diabres.2018.10.008","volume":"146","author":"Vallianou","year":"2018","journal-title":"Diabetes Res Clin Pract"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"156348","DOI":"10.1016\/j.phymed.2024.156348","volume":"136","author":"Feng","year":"2025","journal-title":"Phytomedicine"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"952","DOI":"10.19378\/j.issn.1003-9783.2019.08.010","volume":"30","author":"Peng","year":"2019","journal-title":"Tradit Chin Drug Res Clin Pharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"855","DOI":"10.19879\/j.cnki.1004-745X.2021.05.032","volume":"30","author":"Zhang","year":"2021","journal-title":"J Chin Med Crit Care"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1813086","DOI":"10.1155\/2017\/1813086","volume":"2017","author":"Gao","year":"2017","journal-title":"J Immunol Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s10557-017-6755-9","volume":"31","author":"Magee","year":"2017","journal-title":"Cardiovasc Drugs Ther"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"101115","DOI":"10.1016\/j.gendis.2023.101115","volume":"11","author":"Chen","year":"2023","journal-title":"Genes Dis"},{"key":"ref25","first-page":"2214","volume":"56","author":"Yu","year":"2025","journal-title":"Chin Tradit Herbal Drugs"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"154844","DOI":"10.1016\/j.metabol.2021.154844","volume":"123","author":"Nawrot","year":"2021","journal-title":"Metabolism"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1039\/d0fo03051a","volume":"12","author":"Zhang","year":"2021","journal-title":"Food Funct"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.2337\/db08-0564","volume":"57","author":"Dasu","year":"2008","journal-title":"Diabetes"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nrd.2018.149","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"550","DOI":"10.5551\/jat.65551","volume":"32","author":"Iwasaki","year":"2025","journal-title":"J Atheroscler Thromb"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1016\/j.molimm.2010.04.018","volume":"47","author":"Ferracini","year":"2010","journal-title":"Mol Immunol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1016\/j.cell.2019.05.008","volume":"177","author":"Hammerschmidt","year":"2019","journal-title":"Cell"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.19540\/j.cnki.cjcmm.20170307.014","volume":"42","author":"Li","year":"2017","journal-title":"China J Chin Mater Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.cmet.2007.03.001","volume":"5","author":"Sano","year":"2007","journal-title":"Cell Metab"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"S157","DOI":"10.2337\/dc09-S302","volume":"32","author":"DeFronzo","year":"2009","journal-title":"Diabetes Care"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1007\/s10753-020-01242-9","volume":"43","author":"Singh","year":"2020","journal-title":"Inflammation"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1177\/1753425920933656","volume":"26","author":"Yin","year":"2020","journal-title":"Innate Immun"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"118173","DOI":"10.1016\/j.lfs.2020.118173","volume":"259","author":"Sayed","year":"2020","journal-title":"Life Sci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"8724","DOI":"10.1002\/jcp.29716","volume":"235","author":"Tu","year":"2020","journal-title":"J Cell Physiol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1126\/science.1223813","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/s41577-023-00874-w","volume":"23","author":"Donald","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3390\/nu14010166","volume":"14","author":"Iatcu","year":"2021","journal-title":"Nutrients"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1067\/moe.2000.104477","volume":"89","author":"Guggenheimer","year":"2000","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"3915","DOI":"10.19540\/j.cnki.cjcmm.20210521.701","volume":"46","author":"Ma","year":"2021","journal-title":"China J Chin Mater Med"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"105681","DOI":"10.1016\/j.intimp.2019.105681","volume":"74","author":"Dong","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s12038-025-00531-5","volume":"50","author":"Mandaliya","year":"2025","journal-title":"J Biosci"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.7501\/j.issn.0253-2670.2023.08.012","volume":"54","author":"Kou","year":"2023","journal-title":"Chin Tradit Herbal Drugs"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.pcd.2025.05.002","volume":"19","author":"Charles","year":"2025","journal-title":"Prim Care Diabetes"}],"container-title":["Diabetes, Metabolic Syndrome and Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/108052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/108052","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:18:27Z","timestamp":1761056307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/mechanisms-of-dangguiliuhuang-tang-in-streptozotocin-induced-type-2-di-peer-reviewed-fulltext-article-DMSO"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":48,"URL":"https:\/\/doi.org\/10.2147\/dmso.s525913","relation":{},"ISSN":["1178-7007"],"issn-type":[{"value":"1178-7007","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}