{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:55:27Z","timestamp":1791618927500,"version":"4.3.4"},"reference-count":54,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DMSO"],"DOI":"10.2147\/dmso.s538554","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T07:20:10Z","timestamp":1757402410000},"page":"3343-3361","source":"Crossref","is-referenced-by-count":7,"title":["Hypertension and BMI as Mediators of Type 2 Diabetes-Induced CKD: Insights from an Integrative Multi-Database Study"],"prefix":"10.2147","volume":"Volume 18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7408-0398","authenticated-orcid":true,"given":"Heng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1820-9107","authenticated-orcid":true,"given":"Keyi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3456-2899","authenticated-orcid":true,"given":"Yijie","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e342","DOI":"10.1016\/S2214-109X(24)00050-0","volume":"12","author":"Jadoul","year":"2024","journal-title":"The Lancet Global Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e382","DOI":"10.1016\/S2214-109X(23)00570-3","volume":"12","author":"Bello","year":"2024","journal-title":"The Lancet Global Health"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"381","DOI":"10.7326\/M22-2904","volume":"176","author":"Navaneethan","year":"2023","journal-title":"Annals of Internal Medicine"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.2337\/dci22-0027","volume":"45","author":"de Boer","year":"2022","journal-title":"Diabetes Care"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/s41581-021-00462-y","volume":"17","author":"Oshima","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.kint.2022.08.012","volume":"102","author":"de Boer","year":"2022","journal-title":"Kidney International"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","volume":"402","author":"Ong","year":"2023","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/S2213-8587(23)00225-5","volume":"11","author":"Misra","year":"2023","journal-title":"The Lancet Diabetes & Endocrinology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/s41581-018-0001-y","volume":"14","author":"Anders","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.pcd.2019.11.002","volume":"14","author":"Gonz\u00e1lez-P\u00e9rez","year":"2020","journal-title":"Prim Care Diabetes"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.12659\/MSM.908927","volume":"24","author":"Sun","year":"2018","journal-title":"Med Sci Monit"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.3390\/life12111891","volume":"12","author":"Kim","year":"2022","journal-title":"Life (Basel)"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.2215\/CJN.08900722","volume":"17","author":"Vart","year":"2022","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1016\/S2589-7500(22)00187-X","volume":"5","author":"Kuan","year":"2023","journal-title":"The Lancet Digital Health"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13073-022-01145-4","volume":"15","author":"Liu","year":"2023","journal-title":"Genome Medicine"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/clinchem\/hvab249","volume":"68","author":"Kjaergaard","year":"2022","journal-title":"Clinical Chemistry"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1161\/HYPERTENSIONAHA.122.19744","volume":"79","author":"Ruilope","year":"2022","journal-title":"Hypertension (Dallas, Tex: 1979)"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1016\/S0140-6736(24)00769-4","volume":"403","author":"Murray","year":"2024","journal-title":"Lancet (London, England)"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3945\/an.115.009258","volume":"7","author":"Ahluwalia","year":"2016","journal-title":"Advances in Nutrition)"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1681\/ASN.2016010098","volume":"27","author":"Sekula","year":"2016","journal-title":"Journal of the American Society of Nephrology: JASN"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"483","DOI":"10.12688\/wellcomeopenres.18754.1","volume":"8","author":"Willems","year":"2023","journal-title":"Wellcome Open Research"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1038\/s41467-018-04951-w","volume":"9","author":"Xue","year":"2018","journal-title":"Nat Commun"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.kint.2019.10.027","volume":"97","author":"K\u00f6ttgen","year":"2020","journal-title":"Kidney International"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","volume":"53","author":"Sakaue","year":"2021","journal-title":"Nature Genetics"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ (Clinical Research Ed)"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1038\/s41588-018-0164-2","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nature Genetics"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12967-020-02361-5","volume":"18","author":"Sun","year":"2020","journal-title":"J Transl Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"111884","DOI":"10.1016\/j.diabres.2024.111884","volume":"217","author":"Liu","year":"2024","journal-title":"Diabetes Res Clin Pract"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1586-5","volume":"20","author":"Zhang","year":"2019","journal-title":"BMC Nephrol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/ijms26010025","volume":"26","author":"Wang","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s11684-017-0569-9","volume":"11","author":"Han","year":"2017","journal-title":"Frontiers of Medicine"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3389\/fcell.2020.00187","volume":"8","author":"Zhao","year":"2020","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.mcna.2023.03.004","volume":"107","author":"Gupta","year":"2023","journal-title":"The Medical Clinics of North America"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.2215\/CJN.11491116","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"TD Control, CDR Group. Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes Control and Complications Trial. The Diabetes Control and Complications (DCCT) Research Group. Kidney Int. 1995;47(6):1703\u20131720. doi:10.1038\/ki.1995.236","DOI":"10.1038\/ki.1995.236"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352(9131):837\u2013853. doi:10.1016\/S0140-6736(98)07019-6","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1093\/ndt\/gfad215","volume":"39","author":"Makhammajanov","year":"2024","journal-title":"Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2188967","DOI":"10.1080\/0886022X.2023.2188967","volume":"45","author":"Wang","year":"2023","journal-title":"Ren Fail"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"4236","DOI":"10.1038\/s41598-024-80492-1","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci Rep"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"5629","DOI":"10.2147\/JIR.S433110","volume":"16","author":"Wang","year":"2023","journal-title":"J Inflamm Res"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1002\/oby.23472","volume":"30","author":"Sun","year":"2022","journal-title":"Obesity (Silver Spring, Md)"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.2337\/dc20-2151","volume":"44","author":"Nahra","year":"2021","journal-title":"Diabetes Care"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s12916-021-02188-x","volume":"19","author":"Burgess","year":"2021","journal-title":"BMC Medicine"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.1097\/IMNA-D-24-00064","volume":"12","author":"Wang","year":"2025","journal-title":"Integr Med Nephrol Androl"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00134-019-05594-1","volume":"45","author":"Schetz","year":"2019","journal-title":"Intensive Care Medicine"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.23876\/j.krcp.2017.36.1.1","volume":"36","author":"Park","year":"2017","journal-title":"Kidney Research and Clinical Practice"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s11906-018-0882-y","volume":"20","author":"Vareldzis","year":"2018","journal-title":"Current Hypertension Reports"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/s41569-023-00847-5","volume":"20","author":"Valenzuela","year":"2023","journal-title":"Nature Reviews Cardiology"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.pcad.2022.11.013","volume":"78","author":"Tutor","year":"2023","journal-title":"Prog Cardiovasc Diseases"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.pcad.2024.01.003","volume":"82","author":"Alebna","year":"2024","journal-title":"Prog Cardiovasc Diseases"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.pcad.2013.10.005","volume":"56","author":"Park","year":"2014","journal-title":"Prog Cardiovasc Diseases"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/nu14010013","volume":"14","author":"Okuno","year":"2021","journal-title":"Nutrients"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1136284","DOI":"10.3389\/fnut.2023.1136284","volume":"10","author":"Shen","year":"2023","journal-title":"Frontiers in Nutrition"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000504240","volume":"49","author":"Hanna","year":"2020","journal-title":"Blood Purification"}],"container-title":["Diabetes, Metabolic Syndrome and Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/106758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/106758","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T07:20:16Z","timestamp":1757402416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/hypertension-and-bmi-as-mediators-of-type-2-diabetes-induced-ckd-insig-peer-reviewed-fulltext-article-DMSO"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":54,"URL":"https:\/\/doi.org\/10.2147\/dmso.s538554","relation":{},"ISSN":["1178-7007"],"issn-type":[{"value":"1178-7007","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]}}}